Expert Rev Vaccines. 2022 Aug 26. doi: 10.1080/14760584.2022.2117695. Online ahead of print.
ABSTRACT
BACKGROUND: Pregnant women have a low uptake of influenza vaccination, although being recommended as a priority.
RESEARCH DESIGN AND METHODS: We conducted a cross-sectional questionnaire survey in China from June to July 2021. Hierarchical regression analysis and structural equation modeling were performed based on the extended theory of planned behavior, in which attitudes, subjective norms, perceived behavioral control, and intention each affect the vaccine hesitancy; four variables of response efficacy, knowledge, vulnerability, and severity were added as extended dimensions; vaccination history played a moderator role in this model-to test the validity of the framework.
RESULTS: Totally, 1283 pregnant women participated in this study. The intention existed as a mediator between attitude [βindirect=0.142 (95% confidence interval (CI): 0.084, 0.206), P<0.001], subjective norms [βindirect=0.568 (95%CI: 0.424, 0.754), P<0.001], perceived behavioral control [βindirect=0.070 (95%CI: 0.025, 0.118), P=0.004] and vaccine hesitancy. Further, the differences in indirect effect between the two dimensions of attitude (P<0.001), perceived behavioral control (P<0.001), and subjective norms were each statistically significant. Vaccination history did not moderate the association between attitude (P=0.679), subjective norms (P=0.645), and hesitancy.
CONCLUSIONS: The subjective norms dimension has a strong association with influenza vaccine hesitancy. Vaccination history had limited ability to reduce hesitancy during pregnancy.
PMID:36017619 | DOI:10.1080/14760584.2022.2117695
