Int J Fertil Steril. 2022 Aug 21;16(3):206-210. doi: 10.22074/ijfs.2021.521378.1066.
The purpose of this prospective study was to compare the ovarian response and pregnancy outcomes<br />in the infertile women with endometrioma undergoing assisted reproductive technologies (ART) in two<br />groups, who were underwent laparoscopic cystectomy and received gonadotropin releasing hormone-agonist<br />(GnRH-agonist) and who only received GnRH-agonist without any surgery.<br />Materials and Methods: In this prospective clinical trial study, 79 infertile women with asymptomatic endometriomas<br />cyst (2-6 cm) were enrolled and randomly assigned to two groups. First group underwent laparoscopic<br />cystectomy and received GnRH-agonist. Second group only received GnRH-agonist without any surgery. Following<br />ovulation induction, all patients underwent intracytoplasmic sperm injection (ICSI). Different parameters<br />such as the number of retrieved oocytes and embryos; were made our outcomes that analyzed using SPSS.<br />Results: The pregnancy rate, chemical and clinical, and live birth rate were higher in the combined group,<br />although these differences were not statistically significant (48.48% vs. 30.8%, P=0.12, 36.36% vs. 25.6%,<br />P=0.32, 36.36% vs. 23.1%, P=0.29). The number of injections, antral follicles, retrieved oocytes, mature oocytes,<br />total embryos, transferred embryos and duration of stimulation were similar in two groups.<br />Conclusion: Laparoscopic cystectomy followed by receiving GnRH-agonist improves pregnancy outcomes in endometrioma<br />prior to treatment with ART (registration number: IRCT201106116689N2).