J Clin Sleep Med. 2022 Sep 23. doi: 10.5664/jcsm.10308. Online ahead of print.
ABSTRACT
STUDY OBJECTIVES: The purpose of this study was to conduct a comprehensive assessment of sleep and circadian rhythms in individuals with and without coronary artery disease (CAD).
METHODS: This was a cross-sectional study. Participants were 32 individuals; mean age = 70.9; female 46.9%; 19 with CAD; and 13 without CAD. We assessed sleep quality and 24-hour rest-activity rhythms for 14 days using wrist actigraphy and self-report measures, and circadian rhythm using dim light melatonin onset (DLMO).
RESULTS: Melatonin levels prior to habitual bedtime were significantly lower in individuals with CAD than in those without CAD (median AUC = 12.88 vs. 26.33 pg/ml × h, p = .049). The median circadian timing measured by DLMO was the same for the two groups with 20:26 [hh:mm] for individuals with CAD and 19:53 for the control group (p = .64, r = 0.14). Compared to the control group, the CAD group had significantly lower amplitude (p = .03, r = -.48), and lower overall rhythmicity (pseudo-F-statistic p = .004, r = -.65) in their 24-hour rest-activity rhythms.
CONCLUSIONS: This is one of the first study to comprehensively assess both sleep and circadian rhythm in individuals with CAD. Compared to non-CAD controls, individuals with CAD had lower levels of melatonin prior to habitual bedtime and a lower 24-hour rest-activity rhythm amplitude and overall rhythmicity. Future studies using larger sample sizes should further investigate the possibility of suppressed circadian rhythmicity in individuals with CAD.
PMID:36148612 | DOI:10.5664/jcsm.10308
