Immunology. 2022 Oct 1. doi: 10.1111/imm.13586. Online ahead of print.
ABSTRACT
Not only are many Mycobacteria pathogens, but they can act as strong nonspecific immunopotentiators, generating beneficial effects on the pathogenesis of some diseases. However, there has been no direct evidence of the effect of mycobacterial species on colorectal cancer (CRC). Herein, we showed that there may be a meaningful inverse correlation between the incidence of tuberculosis and CRC based on global statistics and that heat-killed M. tuberculosis and live M. bovis (BCG strain) could ameliorate CRC development. In particular, using a fecal microbiota transplantation and a comparison between separate housing and cohousing, we demonstrated that the gut microbiota is involved in the protective effects. The microbial alterations can be elucidated by the modulation of antimicrobial activities including those of the Reg3 family genes. Furthermore, interleukin-22 production by T helper cells contributed to the anti-inflammatory activity of Mycobacteria. Our results revealed a novel role of Mycobacteria involving gut microbial alterations in dampening inflammation-associated CRC and an immunological mechanism underlying the interaction between microbes and host immunity. This article is protected by copyright. All rights reserved.
PMID:36183156 | DOI:10.1111/imm.13586
