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COVID -19 Vaccinations in pregnancy: Save Mother and Baby from Covid-19 Pandemic

Int J Gynaecol Obstet. 2022 Oct 28. doi: 10.1002/ijgo.14532. Online ahead of print.

ABSTRACT

OBJECTIVE: To study immune response of maternal Covid-19 vaccination and vertical transmission of Anti-SARS-CoV-2, S and N.

STUDY DESIGN: Retrospective study of pregnant women in Bahrain Defense Force Hospital, from March 2021 till September 2021, who were vaccinated, with Sinopharm and Pfizer/Bio NTech. Anti-N and S level from paired samples of maternal and umbilical cord blood was done at the time of delivery with Elecsys Anti-SARS-CoV-2 immunoassay. Immune response to vaccination, association with maternal and fetal factors, and the vertical transmission of antibodies were studied. Analysis was performed using SPSS (version 26.0) and Minitab (version 18) software. P-value of less than 0.05 was considered statistically significant.

RESULTS: The study included 79 pregnant women. The median gestational age for Sinopharm was 28 weeks and Pfizer was 31 weeks. 100% of the vaccinated population generated antibodies and had vertical transmission. The anti-N and S titre, and interval frequencies varied in both vaccinations. The anti-N and S and Transfer ratio are correlated statistically with maternal age, gestational age at delivery, latency period and birth weight of the neonates differently in both vaccines. Also the peak level of antibodies and transfer ratios varied.

CONCLUSION: Though variations are exhibited in both type of vaccination, the vaccinated pregnant population generated a significant level of anti-N and-S, and had vertical transmission as well.

PMID:36306398 | DOI:10.1002/ijgo.14532

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