Diabetes Technol Ther. 2022 Oct 28. doi: 10.1089/dia.2022.0365. Online ahead of print.
ABSTRACT
OBJECTIVE: To evaluate influence of daytime vs nighttime continuous glucose monitoring (CGM)-based metrics on A1C in adults with type 1 diabetes.
RESEARCH DESIGN AND METHODS: CGM data from 407 adults with type 1 diabetes (age 39 ± 15 years, diabetes duration 20 ± 12 years, A1C 7.3 ± 1.4% and 55% female) from two studies were included in this analysis. The association between daytime (6 AM to 10.59 PM) and nighttime (11PM to 5.59 AM) CGM variables such as mean glucose, time in range (TIR; 70-180 mg/dL), time in tight target range (TTIR; 70-140 mg/dL) and time above range (TAR >180 mg/dl) was examined within five A1C categories (<7%, 7- 7.9%, 8-8.9%, 9-9.9%, and ≥10%).
RESULTS: Although mean glucose was increasing with higher A1C, there was no statistical difference in mean glucose between daytime vs nighttime within five A1C groups [143.2±22.7 vs143.6±25.0 for A1C <7%, 171.4±17.3 vs 175.3±28.8 for A1C 7.0-7.9%, 193.4±19.4 vs 195.3±29.5 for A1C 8.0-8.9%, 214.9±28.8 vs 219.7±36.1 for A1C 9.0-9.9% and 244.0±39.0 vs 239.9±50.9 for A1C ≥10%, p>0.05]. Similarly, there was no difference various CGM metrics by daytime vs nighttime within five A1C groups. Differences between five A1C groups’ daytime vs nighttime mean glucose, TIR, TTIR and TAR were also not statistically significant (all p>0.05) Conclusion: Daytime vs nighttime glycemic control has similar influence on A1C in adults with type 1 diabetes.
PMID:36306519 | DOI:10.1089/dia.2022.0365
