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Posterior Corneal Curvature Changes After Pre-Descemet’s Endothelial Keratoplasty: A Prospective Analysis

Cornea. 2022 Dec 1;41(12):1525-1529. doi: 10.1097/ICO.0000000000003033. Epub 2022 Mar 30.


PURPOSE: To assess the changes in the posterior corneal curvature after pre-Descemet’s endothelial keratoplasty (PDEK) and correlate with the visual outcomes.

METHODS: Eyes with pseudophakic bullous keratopathy, aphakic bullous keratopathy, and Fuchs dystrophy undergoing PDEK were included. The main outcome measures were the topography (OrbscanIIz, Bausch and Lomb) indices-total corneal power (TCP) in diopters (D), radius of the posterior curvature (mm), and best-fit sphere of the posterior corneal surface (BFS in D) at preoperative and postoperative 1 month, 3 months, and 6 months.

RESULTS: Overall, 43 eyes of 43 patients with a mean age of 68 ± 9.6 years were studied. The mean preoperative TCP 43.1 D ± 2.3 reduced to 42.4 D ± 2.6 at 3 months (P < 0.010). There was a statistically significant decrease in the mean posterior corneal curvature at 1 month and 3 months postoperatively (P = 0.002). There was no significant change in the TCP and posterior corneal curvature at 6 months (P > 0.05). The mean BFS showed an increase at 1 month (53.45 ± 5.2 D) and 3 months (52.95 ± 5.1 D) and decrease at 6 months (51.90 ± 5.3 D). The overall change in BFS (P > 0.05) was not significant. There was significant improvement in visual acuity (P < 0.05). The best-corrected visual acuity was ≥20/40 in 79.07% and ≥20/60 in 100% at 6 months. There was no statistically significant correlation between the change in the best-corrected visual acuity and TCP, posterior corneal curvature, or BFS.

CONCLUSIONS: Although there was immediate postoperative change in the posterior curvature, no significant change was induced by PDEK.

PMID:36343167 | DOI:10.1097/ICO.0000000000003033

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