J Hepatobiliary Pancreat Sci. 2022 Nov 18. doi: 10.1002/jhbp.1275. Online ahead of print.
ABSTRACT
BACKGROUND: The 2018 Tokyo Guidelines (TG18) recommend urgent endoscopic biliary drainage based on acute cholangitis (AC) severity. Therefore, we evaluated the safety and mortality benefits of urgent endoscopic retrograde cholangiopancreatography (ERCP) in different age groups.
METHODS: Using International Classification of Diseases-10 (ICD-10) codes, we sampled adult AC patients from National Inpatient Sample. TG18 definition of cholangitis severity was used to identify patients with severe and non-severe (mild or moderate) AC. Age categories were 18 to 64, 65 to 79, and 80 and above. Multivariate linear or logistic regression was used as appropriate. We used Stata, version 14.2, to perform analyses considering 2-sided P< 0.05 as statistically significant.
RESULTS: Among 137,100 patients, there were 93,365 (68.09%) patients with non-severe cholangitis and 43,735 (31.91%) patients with severe cholangitis. Urgent ERCP (within 24 hours) resulted in decreased mortality in all age groups for both severe and non-severe AC. Post-sphincterotomy bleeding was more common in patients ≥80 years of age, whereas post-ERCP acute cholecystitis was more common in patients 65-79 years. The rates of post-ERCP pancreatitis, bile duct perforation, and duodenal perforation did not differ among the age groups. In addition, there were no differences in the rate of sedation-related complications between different age groups who underwent urgent ERCP.
CONCLUSION: This study demonstrates the mortality benefit from urgent ERCP for AC in different age groups and describes the safety of performing urgent ERCP in patients of various ages. Therefore, we recommend that urgent ERCP be performed according to the TG18 guidelines regardless of age.
PMID:36399089 | DOI:10.1002/jhbp.1275
