Expert Opin Drug Saf. 2023 Jan 6. doi: 10.1080/14740338.2023.2166485. Online ahead of print.
ABSTRACT
BACKGROUND: This study aimed to evaluate efficacy and safety of dapagliflozin as a monotherapy glucose lowering drug treatment for older adults with diabetes.
RESEARCH DESIGN & METHODS: Randomised controlled trials (RCTs) reports were retrieved from PubMed, Embase Cochrane Library and Web of Science from database inception to May 8, 2021. Publication bias and heterogeneity were assessed using the Cochrane risk-of-bias tool and the Cochrane Q statistic, respectively.
RESULTS: Compared with placebo, dapagliflozin as a monotherapy glucose lowering drug did improve the control of HbA1c and fasting plasma glucose levels in older adults. Our analysis also confirmed that the body weight of older adults was well controlled under treatment of dapagliflozin as a monotherapy glucose lowering drug. Patients in older adults with diabetes took a higher risk of genital infection and renal impairment or failure after treatment of dapagliflozin. In addition, treatment with dapagliflozin reduced risk of hypoglycemia, and did not reveal increased risk of urinary tract infection and developing fractures compared to placebo in older adults.
CONCLUSION: Dapagliflozin as a monotherapy glucose lowering drug appeared to be an effective treatment for older adults with diabetes, although it might increase risk of genital infection and renal impairment or failure.
PMID:36608279 | DOI:10.1080/14740338.2023.2166485
