Int J Gynaecol Obstet. 2023 Jan 23. doi: 10.1002/ijgo.14690. Online ahead of print.
ABSTRACT
OBJECTIVE: To investigate the effect of the long-acting gonadotropin-releasing hormone agonist (GnRHa) long protocol on in vitro fertilization (IVF) outcomes of patients with endometriosis (EMs).
METHODS: This retrospective cohort study was carried out from July 1st 2016 to June 30th 2021. 798 patients with EMs who underwent first IVF were enrolled. The patients were classified by the ovarian stimulation protocols. The clinical outcomes of IVF were compared in each group.
RESULTS: These EMs patients who received the long-acting GnRHa long protocol had significantly higher clinical pregnancy rate (72.00%, 60.70% and 50.90%, respectively; P=0.047 and 0.010) and implantation rate (51.0%, 44.6%, and 38.7%, respectively; P=0.006 and <0.001) compared with short-acting GnRHa long protocol and GnRH antagonist protocol. Live birth rate was also significantly higher than GnRH antagonist protocol (60.10% and 40.0% P=0.032), but not statistically difference compared with short-acting GnRHa (60.10% and 53.80%, P=0.443). In addition, they also had significantly higher duration of stimulation, total dose of gonadotrophin (Gn) and the number of high quality embryo transferred than other groups (P<0.001).
CONCLUSIONS: Long-acting GnRHa long protocol could improve IVF outcomes of patients with EMs compared with short-acting GnRHa long protocol and GnRH antagonist protocol.
PMID:36688363 | DOI:10.1002/ijgo.14690
