Nevin Manimala Statistics

Prevalence of molar incisor hypomineralization in India: A systematic review and meta-analysis

J Indian Soc Pedod Prev Dent. 2022 Oct-Dec;40(4):356-367. doi: 10.4103/jisppd.jisppd_462_22.


RESEARCH QUESTION: To estimate the pooled prevalence of molar incisor hypomineralization (MIH) in children from India.

RESEARCH PROTOCOL: The PRISMA guidelines were followed.

LITERATURE SEARCH: An electronic search of the databases was performed to find prevalence studies of MIH in children above age 6 years in India.

DATA EXTRACTION: Two authors independently extracted the data from the 16 included studies.

QUALITY APPRAISAL: The risk of bias was assessed using a modified version of the Newcastle-Ottawa Scale adapted for cross-sectional studies.

DATA ANALYSIS: The pooled prevalence estimate of MIH was calculated using logit transformed data with inverse variance approach in a random-effects model with 95% confidence interval (CI). Heterogeneity was assessed with the I2 statistic. The subgroups were analyzed to assess the pooled prevalence of MIH according to sex, arch-wise proportion of MIH-affected teeth, and proportion of children with the MIH phenotypes.

RESULTS AND INTERPRETATION OF RESULTS: Sixteen studies included in the meta-analysis represented 7 states of India. A total of 25,273 children were included in the meta-analysis. The pooled prevalence of MIH in India was estimated to be 10.0% (95% CI: 0.07, 0.12) with significantly high heterogeneity between the included studies. The pooled prevalence did not vary according to sex. The pooled proportions of MIH-affected teeth were similar in the maxillary and mandibular arches. The pooled proportion of children with MH phenotype was higher (56%) than those with M + IH phenotype (44%). Further studies with standardized criteria for recording MIH are needed to ascertain the prevalence of MIH in India.

PMID:36861551 | DOI:10.4103/jisppd.jisppd_462_22

By Nevin Manimala

Portfolio Website for Nevin Manimala