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Evaluation of combination therapies with colistin in an experimental mouse pneumonia model induced by carbapenem-resistant Acinetobacter baumannii strain

Fundam Clin Pharmacol. 2023 Mar 10. doi: 10.1111/fcp.12891. Online ahead of print.


The treatment options are limited in A.baumannii infections. In this study, the effectiveness of colistin monotherapy and combinations of colistin with different antibiotics were investigated in an experimental pneumonia model induced by carbapenem-resistant A. baumannii strain. Mice in the study were divided into five groups as control (no treatment), colistin monotherapy, colistin+sulbactam, colistin+imipenem and colistin+tigecycline combinations. Modified experimental surgical pneumonia model of Esposito and Pennington was applied to all groups. The presence of bacteria in blood and lung samples was investigated. Results were compared. In blood cultures while there was no difference between the control and colistin group, there was a statistical difference between the control and the combination groups (p=0,029). When the groups were compared in terms of lung tissue culture positivity, there was a statistical difference between the control group and all treatment groups (colistin, colistin + sulbactam, colistin + imipenem, and colistin + tigecycline) (p=0.026, p=<0.001, p=<0.001, p=0.002 respectively). The amount of microorganisms that grew in the lung tissue was found to be statistically significantly lower in all treatment groups in comparison with the control group (p= 0.001). Both monotherapy and combination therapies of colistin were found to be effective in the treatment of carbapenem-resistant A.baumannii pneumonia, but the superiority of combination therapies over colistin monotherapy has not been demonstrated.

PMID:36905104 | DOI:10.1111/fcp.12891

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