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Efficacy of surgical treatment for post-prostatectomy urinary incontinence: A systematic review and network meta-analysis

Int J Surg. 2023 Feb 16. doi: 10.1097/JS9.0000000000000170. Online ahead of print.


OBJECTIVES: Post-prostatectomy urinary incontinence (PPUI) is a major complication that reduces the quality of life in patients undergoing prostatectomy for benign prostate hyperplasia (BPH) and prostate cancer (PCa). However, there are currently limited guidelines on which surgical techniques are preferred after conservative treatment for PPUI. In this study, a systematic review and network meta-analysis (NMA) that can help determine the priority for the selection of surgical methods were performed.

MATERIALS AND METHODS: We retrieved data from electronic literature searches of PubMed and the Cochrane Library through August 2021. We searched for randomized controlled trials (RCT) studies on the surgical treatment of PPUI after surgery for BPH or PCa and included the terms artificial urethral sphincter (AUS), adjustable sling, non-adjustable sling, and injection of the bulking agent.The NMA pooled the odds ratios (OR) and 95% credible intervals (CrI) using the number of patients achieving urinary continence, weight of pads used per day, number of pads used per day, and the International Consultation on Incontinence Questionnaire (ICIQ) score. The therapeutic effect of each intervention on PPUI was compared and ranked using the surface under the cumulative ranking curve (SUCRA).

RESULTS: A final 11 studies, including 1116 participants, were included in our NMA. The pooled overall ORs of patients achieving urinary continence compared with no treatment was 3.31 (95% CrI: 0.749, 15.710) in AUS, 2.97 (95% CrI: 0.412, 16.000) in adjustable sling, 2.33 (95% CrI: 0.559, 8.290) in non-adjustable sling, and 0.26 (95% CrI: 0.025, 2.500) in injection of bulking agent. In addition, this study shows the SUCRA values of ranking probabilities for each treatment performance, which indicated that AUS ranked first in terms of continence rate, ICIQ, pad weight, and pad use count.

CONCLUSION: The results of this study suggested that only AUS had a statistically significant effect compared to the non-treatment group and the highest PPUI treatment effect ranking among other surgical treatments.

PMID:36912884 | DOI:10.1097/JS9.0000000000000170

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