Eur J Neurol. 2023 Mar 13. doi: 10.1111/ene.15777. Online ahead of print.
ABSTRACT
BACKGROUND: The genetics of late seizure or epilepsy secondary to traumatic brain injury (TBI) or stroke is poorly understood. We undertook a systematic review to test the association of single nucleotide polymorphisms (SNPs) with the risk of posttraumatic epilepsy (PTE) and post-stroke epilepsy (PSE).
METHODS: We followed methods from our prespecified protocol on PROSPERO to identify indexed articles for this systematic review. We collated the association statistics from the articles to assess the association of SNPs with the risk of epilepsy amongst TBI or stroke patients. We assessed the study quality using the Q-Genie tool. We report Odds Ratio (OR) and Hazard Ratio with a 95% confidence interval (CI).
RESULTS: The literature search yielded 420 articles. We included 16 studies in our systematic review, of which seven were of poor quality. We examined published data on 127 SNPs from 32 genes identified in PTE and PSE patients. Eleven SNPs were associated with a significantly increased risk of PTE. Three SNPs, TRMP6 rs2274924, ALDH2 rs671, and CD40 -1C/T, were significantly associated with an increased risk of PSE, while two SNPs, AT1R rs12721273 and rs55707609, were significantly associated with reduced risk. The meta-analysis for the association of the APOE 𝜀4 with PTE was non-significant (OR 1.8, CI 0.6-5.6).
CONCLUSIONS: The current evidence on the association of genetic polymorphisms in epilepsy secondary to TBI or stroke is of low quality and lacks validation. A collaborative effort to pool genetic data linked to epileptogenesis in stroke and TBI patients is warranted.
PMID:36912749 | DOI:10.1111/ene.15777
