AIDS Res Hum Retroviruses. 2023 Mar 16. doi: 10.1089/AID.2022.0076. Online ahead of print.
ABSTRACT
Epidemiological results have shown that some factors such as co-infection of SARS-COV-2 and HIV is associated with COVID-19 severity, rates of hospitalization, and mortality. Thus, this meta-analysis aims to assess the odds ratio of hospitalization rate, mortality and average standardized difference of CD4 counts in COVID-19/ HIV co-infection patients vs control group.This meta-analysis was examined by PRISMA-P checklist. Studies were obtained from online databases such as Science direct, Pub med, Scopus, Web of Science, and Google scholar using Mesh و Non-Mesh keywords. NOS checklist was used to assess the quality of studies. According to the random effect models, the odds ratio of hospitalization, mortality, and average standardized difference of CD4 counts was estimated. Data analysis was performed using Stata ver.14 software. By the use of strict inclusion criteria, 8 initial studies entered into the meta-analysis. The odds ratio of hospitalization and mortality rates in COVID-19 patients with HIV was 1.67(95% CI: 0.76, 3.71) and 0.80 (95% CI: 0.57, 1.11) times higher than that of the control group. In this meta-analysis, there was no observed a statistically significant difference in the rate of hospitalization, mortality and CD4 counts in COVID-19 patients with HIV and the control group. However, the hospitalization rate in COVID-19/ HIV co-infection patients was 67% higher than the control group. The similarity results between two groups can probably be attributed to some factors, such as the low number of COVID-19/ HIV co-infection patients and the presence of random error, HIV patients receiving antiretroviral therapy, and early hospitalization in COVID-19/ HIV co-infection patients.
PMID:36924275 | DOI:10.1089/AID.2022.0076
