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Breaking Up Evening Sitting with Resistance Activity Improves Postprandial Glycemic Response: A Randomized Crossover Study

Med Sci Sports Exerc. 2023 Mar 10. doi: 10.1249/MSS.0000000000003166. Online ahead of print.


INTRODUCTION: Interrupting sedentary time during the day reduces postprandial glycemia (a risk factor for cardio-metabolic disease). However, it is not known if benefits exist for postprandial glucose, insulin and triglyceride responses in the evening, and if these benefits differ by BMI category.

METHODS: In a randomized crossover study, 30 participants (aged 25.4 ± 5.4 years; BMI 18.5-24.9: n = 10, BMI 25-29.9: n = 10, BMI ≥30: n = 10), completed two intervention arms, beginning at ~1700 h: prolonged sitting for 4 h; and sitting with regular activity breaks of 3 min of resistance exercises every 30 min. Plasma glucose, insulin, and triglyceride concentrations were measured in response to two meals fed at baseline and 120 min. Four-hour incremental area under the curve (iAUC) was compared between interventions. Moderation by BMI status was explored.

RESULTS: Overall, when compared to prolonged sitting, regular activity breaks lowered plasma glucose and insulin iAUC by 31.5% (95% CI -49.3% to -13.8%) and 26.6% (-39.6% to -9.9%), respectively. No significant differences were found for plasma triglyceride AUC. Interactions between BMI status and intervention was not statistically significant.

CONCLUSIONS: Interventions that interrupt sedentary time in the evening may improve cardiometabolic health by some magnitude in all participants regardless of bodyweight.

PMID:36921112 | DOI:10.1249/MSS.0000000000003166

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