Alcohol Clin Exp Res. 2023 Mar 16. doi: 10.1111/acer.15054. Online ahead of print.
BACKGROUND: Endorsement of specific DSM-IV alcohol use disorder (AUD) criteria items changed significantly over time in men in their thirties with persistent or recurrent AUD. Few studies have documented whether endorsement of AUD items change over time in younger individuals or in women. The prospective analyses presented here evaluate changes in endorsement of AUD criteria in 377 men and women with persistent or recurrent AUD during their twenties.
METHODS: AUD item endorsement over time between average ages of 20 and 25 in 223 men and 154 women with persistent or recurrent AUD in at least three interviews were available from participants in the Collaborative Study on the Genetics of Alcoholism. Statistical significance of endorsement changes over time were evaluated using related-samples Cochran’s Q for the full sample and for men and women separately. Additional analyses evaluated potential sex differences in the patterns of change.
RESULTS: In the full sample, the predominant pattern was for significant increased rates of endorsements for six of the seven alcohol dependence criteria, but not in the four abuse items. A similar pattern was seen within men, but women demonstrated significant changes in only three of the seven dependence criteria.
CONCLUSIONS: Endorsement of the seven alcohol dependence criteria during the twenties generally increased in individuals with persistent or recurrent AUD, but few changes were observed regarding rates of endorsement of the four abuse items. The paper discusses how the results might reflect on the nature of AUD and on the DSM criteria.
PMID:36924463 | DOI:10.1111/acer.15054