J Glaucoma. 2023 Jun 15. doi: 10.1097/IJG.0000000000002253. Online ahead of print.
ABSTRACT
PRCIS: The thicknesses of the circumpapillary retinal nerve fiber layer and ganglion cell complex did not change during 5 years in physiological large disc cupping.
PURPOSE: We evaluated longitudinal changes in the thicknesses of the circumpapillary retinal nerve fiber layer (cpRNFL) and ganglion cell complex (GCC) in large disc cupping with a normal intraocular pressure (IOP) (<21 mmHg) and visual field.
METHODS: This retrospective, consecutive case series study included 269 eyes of 269 patients with large disc cupping and normal IOP. We analyzed patient demographics, IOP, central corneal thickness, vertical cup-to-disc ratios (vCDR) using color fundus photography, the thicknesses of the cpRNFL and GCC using RTVue-100, and mean deviation (MD) using visual field examinations.
RESULTS: The differences in IOP, vCDR, and MD between the baseline and each follow-up visit were not statistically significant. The baseline average and mean average at 60 months follow-up of the cpRNFL thickness were 106.5±8.5 μm and 105.1±9.3 μm, respectively; differences between the baseline and each follow-up visit were not statistically significant. The baseline average and mean average at 60 months follow-up of the GCC thickness were 82.8±9.7 μm and 81.5±9.2 μm, respectively; differences between baseline and each follow-up visit were not statistically significant.
CONCLUSION: The thicknesses of the cpRNFL and GCC did not change in well-maintained optic nerve head (ONH) findings with normal IOP and visual field during a 5-year follow-up period. Optical coherence tomography evaluations of the thicknesses of the cpRNFL and GCC help accurately diagnose physiological optic disc cupping.
PMID:37327476 | DOI:10.1097/IJG.0000000000002253
