Nevin Manimala Statistics

The Ganglion Cell Complex Damage in Coronary Artery Disease

Photodiagnosis Photodyn Ther. 2023 Sep 2:103789. doi: 10.1016/j.pdpdt.2023.103789. Online ahead of print.


PURPOSE: This study aims to investigate the correlation between macular thickness, retinal nerve fiber layer thickness, ganglion cell complex thickness, and Gensini scores in patients who have undergone coronary angiography, using spectral-domain optical coherence tomography.

METHODS: We retrospectively evaluated optical coherence tomography results from patients who had undergone coronary angiography between January 2019 and January 2021 due to coronary artery disease, with angiography performed within one month of the optical coherence tomography examination. Based on their Gensini scores, patients were classified into two groups: mild coronary artery disease (Gensini score ≤ 20, Group 1) and severe coronary artery disease (Gensini score > 20, Group 2).

RESULTS: Group 1 comprised 28 patients with an average age of 61.3±10.2, while Group 2 consisted of 25 patients with an average age of 65.4±9.6. While there was no statistically significant difference found in retinal nerve fiber layer and macular thickness between the groups, the ganglion cell complex thickness was significantly thinner in Group 2 in the inner superior temporal (112.55±34.12 µm vs. 99.68±37.81 µm, p= 0.026), inner superior nasal (121.14±32.92 µm vs. 108.36±24.53 µm, p=0.012), inner inferior nasal (120.81±32.34 µm vs. 108.45±12.53 µm, p=0.048), and superior (99.11±25.91 µm vs. 88.77±16.75 µm, p=0.020) regions. Furthermore, a significant negative correlation was observed between the Gensini score and the ganglion cell complex thickness in both the inner superior nasal and superior regions.

CONCLUSION: Compared to patients with mild coronary artery disease, those with severe disease exhibited a significant decrease in ganglion cell complex thickness in the superior and inner superior nasal regions.

PMID:37666380 | DOI:10.1016/j.pdpdt.2023.103789

By Nevin Manimala

Portfolio Website for Nevin Manimala