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Association between psoriasis and cardiometabolic comorbidities in a racially and ethnically diverse low-income primary care population

Clin Exp Dermatol. 2023 Oct 24:llad359. doi: 10.1093/ced/llad359. Online ahead of print.


Psoriasis is associated with cardiometabolic comorbidities, including obesity, diabetes, hyperlipidemia, and hypertension. Many studies that established these associations originated from primarily White and/or relatively affluent populations. To evaluate whether there is differential risk for cardiometabolic comorbidities in racial/ethnic minorities, we performed a cross-sectional analysis comparing cardiometabolic comorbidities between those with and without psoriasis in a racially and ethnically diverse population of 56,987 low-income patients, stratified by race/ethnicity, and assessed whether race/ethnicity acts as an effect modifier for cardiometabolic comorbidities. We found that psoriasis was statistically significantly associated with obesity, diabetes, hyperlipidemia, and hypertension. The association of psoriasis with comorbidities did not differ significantly by race/ethnicity; thus, we did not find evidence of effect modification. However, our diverse, low-income population had an extremely high baseline prevalence of cardiometabolic comorbidities compared with previous populations studied. Our results suggest education and intervention regarding modifiable risk factors are particularly important among vulnerable populations.

PMID:37874979 | DOI:10.1093/ced/llad359

By Nevin Manimala

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