JAMA Dermatol. 2023 Nov 15. doi: 10.1001/jamadermatol.2023.4445. Online ahead of print.
CLINICAL QUESTION: What are the most effective systemic medications to treat plaque psoriasis?
BOTTOM LINE: The most effective drugs for psoriasis were infliximab, bimekizumab, ixekizumab, and risankizumab, and the clinical effectiveness was similar when these 4 drugs were compared against one another. No statistically significant differences in serious adverse events were identified in any of the drugs compared with placebo. The main limitations of this meta-analysis include the lack of assessment of clinical effectiveness beyond 52 weeks and the lack of safety assessments for nonserious adverse events.