J Gastrointest Surg. 2024 Mar 30:S1091-255X(24)00391-3. doi: 10.1016/j.gassur.2024.03.029. Online ahead of print.
ABSTRACT
BACKGROUND: Although many guidelines recommend performing lymph node dissection (LND) during surgery for intrahepatic cholangiocarcinoma (ICC), there is no evidence for incidentally detected ICC patients who did not undergo LND. This study aimed to identify the role of lymph node dissection in patients with incidental ICC.
METHODS: The data from 284 patients who had undergone radical surgery for ICC from 2000 to 2020 were retrospectively reviewed. The enrolled patients were divided into three groups according to their T stage (T1 vs. T2 vs. T3+4). Moreover, the patients of each T group were divided into three groups according to their nodal status (N0 vs. N1 vs. Nx) and their survival outcomes were compared.
RESULTS: Survival outcomes of Nx group were statistically similar to that of N0 group in T1 stage (Nx vs. N0: disease-free survival (DFS) (months), 129.0 [75.6-182.4] vs. 125.0 [65.7-184.3], p=0.948; overall survival (OS) (months), 175.0 [153.9-196.1] vs. 173.0 [109.0-237.0], p=0.443). On the other hand, survival outcomes of Nx group in the other T stage (T2 and T3+4) were poorer than that of N0 group and were better than that of N1 group. In addition, in the Nx subgroup analysis according to T stage, T1 group showed significantly better survival outcomes than the other groups. (T1 vs. T2 vs. T3+4: DFS (months), 129.0 [75.9-182.1] vs. 16.0 [9.8-22.2] vs. 13.0 [0.3-25.7], p<0.001; OS (months), 175.0 [153.9-196.1] vs. 53.0 [30.8-75.2] vs. 37.0 [17.6-56.4], p<0.001) CONCLUSION: ICC patients incidentally diagnosed with T2 or above T stage may consider additional LND.
PMID:38561087 | DOI:10.1016/j.gassur.2024.03.029
