World Neurosurg. 2024 Apr 2:S1878-8750(24)00534-5. doi: 10.1016/j.wneu.2024.03.148. Online ahead of print.
ABSTRACT
INTRODUCTION: Depression and anxiety are common in patients undergoing spinal surgery and might negatively impact outcomes. This study investigates the possible effect of these diagnoses on patient reported outcomes following lumbar fusion.
METHODS: Retrospective review of a registry containing prospectively collected data of lumbar fusion procedures at a single institution was performed from 5/23/2012 to 6/15/2022. Patients with a minimum of two year follow up were included. Demographic information, diagnoses,medications, patient-reported outcomes measures (PROMs), and complications data at preoperative, three months, six months, one year, and two years postoperative were collected. Statistical analysis was performed using Student’s T-tests, χ2, binomial correlation, odds ratios, logistic regression, and Mean Clinically Important Difference (MCID).
RESULTS: A total of 156 patients were included (60 male, 96 female) with mean age 62.6±11.1 years at surgery. Thirty-nine (25%) had depression and/or anxiety (DA). Baseline Oswestry Disability Index (ODI) and EQ5D scores were significantly worse in the DA cohort compared to controls (ODI 51.1±18.3 vs. 42.9±15.8; p=0.010, EQ5D 0.46±0.21 vs. 0.57±0.21; p=0.005). Both cohorts experienced similar relative improvement at two years (delta ODI -18.2±27.9 vs. -17.8±22.1; p=0.924, EQ5D 6.8±33.8 vs 8.1±32.9; p=0.830). Absolute outcome scores were worse in the DA cohort at all intervals. DA were not independently predictive of changes in PROMs (delta ODI mean difference 4.49, r2=0.36, p=0.924).
CONCLUSION: The present study showed similar improvement in PROMs following lumbar fusion for patients with anxiety and depression compared to healthy controls. These data suggest these patients are no less likely to benefit from appropriately planned lumbar fusion.
PMID:38575064 | DOI:10.1016/j.wneu.2024.03.148
