Nevin Manimala Statistics

Ancient DNA speaks

Med Sci (Paris). 2024 Jun-Jul;40(6-7):563-565. doi: 10.1051/medsci/2024070. Epub 2024 Jul 8.


Many human DNA sequences have been obtained from ancient remains dating back from several millennia. However, these have low coverage and may contain many errors; this has limited their usefulness for many analyses, in particular the search for Identical By Descent (IBD) segments that is very powerful for detection of kinship. A new method, using imputation from database data and sophisticated statistical analysis, proves able to detect IBD segments (and thus parenthood) in low-quality DNA sequences from individuals linked only by sixth degree parenthood, opening a whole new field of investigation using ancient DNA.

PMID:38986104 | DOI:10.1051/medsci/2024070

By Nevin Manimala

Portfolio Website for Nevin Manimala