Nevin Manimala Statistics

Determination of Sample Size for Different Clinical Study Designs

J Assoc Physicians India. 2024 Jul;72(7):34-40. doi: 10.59556/japi.72.0492.


AIM: This study illustrates parameters, procedures, and calculations for the statistical determination of sample size for different clinical study designs.

MATERIALS AND METHODS: In any research process, the sample size is an important consideration for the implementation of the planned study. From time to time, literature on sample size has been documented in the medical literature. However, the situations covered under them lack comprehensiveness in terms of different study designs, demonstration of calculations, and overreliance on statistical software.

RESULTS: The present study provides various facets of sample size determination, such as prerequisite parameters, mathematical formulation, and calculations for clinical study designs [descriptive studies, randomized controlled trials (RCT), correlational studies, comparison of multiple outcomes, survival analysis, sensitivity, and specificity], which will be quite useful.

CONCLUSION: This communication will be a good education and learning source for medical professionals to pick and choose a specific scenario and estimate the sample size.

PMID:38990585 | DOI:10.59556/japi.72.0492

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