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Vitamins Can Increase Antibiotic Effects Against Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii in an In Vitro Infection Model

Eurasian J Med. 2024 Jun;56(2):91-97. doi: 10.5152/eurasianjmed.2024.23145.

ABSTRACT

METHODS: The study delves into the antimicrobial properties of vitamins P, K, and E against A. baumannii and P. aeruginosa, employing the minimum inhibitory concentration method and scrutinizing biofilm formation within the A549 cell culture.

RESULTS: The combined application of vitamins and antibiotics exhibited a statistically significant effect on both the minimal inhibitory concentration values and biofilm formation (P < .05). Within the realm of fat-soluble vitamins, vitamins K and E, when integrated with antibiotics, revealed varying degrees of influence, with vitamin K displaying the most substantial fractional inhibitory concentration value. Vitamin E, on the other hand, demonstrated a comparatively weaker fractional inhibitory concentration than the other constituents. Nevertheless, it exhibited robust optical density and a pronounced capacity to inhibit biofilm formation. Moreover, among the vitamin groups, it is evident that vitamin E surpasses the efficacy of others (antibacterials affecting K < P <E). The collective application of all vitamins manifested the most potent fractional inhibitory concentration.

CONCLUSION: The synergistic effects of vitamins with antibiotics, as evidenced in this study, may offer a promising alternative for treating multidrug-resistant A. baumannii and P. aeruginosa, subject to further investigation through molecular studies.

PMID:39128047 | DOI:10.5152/eurasianjmed.2024.23145

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