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Electrographic seizures during low-current thalamic deep brain stimulation in mice

Brain Stimul. 2024 Aug 10:S1935-861X(24)00139-6. doi: 10.1016/j.brs.2024.08.002. Online ahead of print.

ABSTRACT

BACKGROUND: Deep brain stimulation of central thalamus (CT-DBS) has potential for modulating states of consciousness, but it can also trigger electrographic seizures, including poly-spike-wave trains (PSWT).

OBJECTIVES: To report the probability of inducing PSWTs during CT-DBS in awake, freely-moving mice.

METHODS: Mice were implanted with electrodes to deliver unilateral and bilateral CT-DBS at different frequencies while recording EEG. We titrated stimulation current by gradually increasing it at each frequency until a PSWT appeared. Subsequent stimulations to test arousal modulation were performed at the current one step below the current that caused a PSWT during titration.

RESULTS: In 2.21% of the test stimulations (10 out of 12 mice), CT-DBS caused PSWTs at currents lower than the titrated current, at currents as low as 20 μA.

CONCLUSION: Our study found a small but significant probability of inducing PSWTs even after titration and at relatively low currents. EEG should be closely monitored for electrographic seizures when performing CT-DBS in both research and clinical settings.

PMID:39134207 | DOI:10.1016/j.brs.2024.08.002

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