Neuroradiol J. 2026 May 11:19714009261450379. doi: 10.1177/19714009261450379. Online ahead of print.
ABSTRACT
BackgroundThis study aims to assess whether T2 relaxometry can distinguish tissue characteristics between high-grade gliomas and non-infiltrative lesions.MethodsWe report our initial experience using the Relaxo LNI software to analyze multi-echo T2 relaxometry magnetic resonance imaging in patients with high-grade gliomas. For comparison, peritumoral T2-hyperintense areas in meningiomas and metastases were used as reference regions for vasogenic edema, based on the established concept that these tumor types typically do not infiltrate adjacent tissue. In contrast, peritumoral hyperintensity observed in high-grade gliomas may represent either vasogenic edema or tumor infiltration.ResultsData from 30 patients were analyzed, including 20 with high-grade gliomas and 10 with metastasis or meningiomas. A statistically significant difference was observed in multi-echo T2 relaxation values between the glioma and non-glioma groups (p < 0.05). Mean T2 relaxation times were longer in the high-grade glioma group than in the non-glioma group (p < 0.05). Within the high-grade glioma group, central regions showed significantly longer mean relaxation times than peripheral regions (p < 0.05).ConclusionOur preliminary findings suggest that T2 relaxometry identifies differences in relaxation profiles between tumor tissue and control edema, indicating potential value in detecting variations in peritumoral tissue composition in high-grade gliomas. However, these results are exploratory and hypothesis-generating, lack histopathological validation, and require further investigation to clarify the role of T2 mapping in preoperative planning.
PMID:42109220 | DOI:10.1177/19714009261450379
