Int Urol Nephrol. 2026 May 17. doi: 10.1007/s11255-026-05207-z. Online ahead of print.
ABSTRACT
PURPOSE: The benefits of incremental peritoneal dialysis (IPD) with days off remain controversial. This study aimed to compare the survival rate between IPD with days off and standard-dose peritoneal dialysis (PD).
METHODS: Participants who started continuous peritoneal dialysis (CAPD) between October 1, 2020 and November 30, 2021, in a tertiary hospital in Thailand were enrolled. IPD with two days off (performed 5 days a week) and standard-dose PD (performed every day) were compared using propensity score matching at a 1:1 ratio for baseline characteristics. The primary outcome was 1-year patient survival. One-year PD continuation rate, PD-associated peritonitis rate, admission rate, and weekly Kt/V at 6 weeks, 6 months, and 12 months were analyzed.
RESULTS: The 118 eligible patients (37 IPD and 81 standard-dose PD) were included. After propensity score matching, the groups were compared. One-year patient survival rates were comparable between groups, with no statistically significant difference (94.3% vs. 97.4% in the IPD and standard-dose PD groups, respectively; hazard ratio (HR) 2.15, 95% confidence interval (CI) 0.19-23.75). The 1-year PD continuation, PD-associated peritonitis rate, and admission rate were comparable between groups. Total weekly Kt/V over the 12 months showed no significant change over time.
CONCLUSION: IPD with days off appears to be safe and comparable to standard-dose PD in terms of short-term patient survival.
PMID:42144488 | DOI:10.1007/s11255-026-05207-z
