Acta Otolaryngol. 2026 May 19:1-9. doi: 10.1080/00016489.2026.2667889. Online ahead of print.
ABSTRACT
BACKGROUND: Overlapping signal intensities in conventional MRI limit parotid tumor characterization, necessitating advanced techniques like arterial spin labeling (ASL) to assess physiological parameters such as vascularity.
OBJECTIVES: To evaluate the diagnostic performance of ASL in differentiating parotid gland tumors by quantifying tumor blood flow ASLm (mean) and ASLmax (maximum) and determining optimal cutoff values correlated with histopathological findings.
METHODS: Forty-seven patients (20 pleomorphic adenomas [PA], 20 Warthin tumors [WT], 7 malignant) underwent standardized 1.5 T MRI protocols and ASL prior to parotidectomy. Quantitative ASL values were obtained from lesions and contralateral tissue. Statistical comparisons and ROC analyses were performed to identify diagnostic cutoff values.
RESULTS: ASLm and ASLmax values were higher in WT compared to PA (p < 0.01). No significant side-to-side differences were found in PA and malignant groups. For PA differentiation, ASLm and ASLmax yielded AUCs of 0.766 (p = 0.002) and 0.742 (p = 0.005), respectively. For WT differentiation, both parameters showed excellent performance, yielding AUCs of 0.774 (p < 0.001) and 0.769 (p = 0.002).
CONLUSIONS: While ASL perfusion MRI effectively differentiates common benign parotid tumors, its limitations in malignancy evaluation necessitate its integration into a multiparametric MRI protocol for a more reliable preoperative diagnosis.
PMID:42154491 | DOI:10.1080/00016489.2026.2667889
