Urol J. 2026 May 24. doi: 10.22037/uj.v23i00.8514. Online ahead of print.
ABSTRACT
BACKGROUND: Acute kidney injury is a common disease in hospitalized patients, which can have a significant impact on outcomes, including an increase in overall complications and mortality rates, criteria such as serum creatinine level, urinary output, And scoring systems such as KDIGO in acute conditions do not have acceptable specificity and sensitivity to evaluate the kidney function of people; Therefore, this study was conducted with the aim of determining the relationship between plasma uric acid level and mortality rate in patients with sepsis and acute kidney failure.
METHODS: In this descriptive-analytical (cross-sectional) study included 52 children , with the age range of one month to 15 years with sepsis (based on qSOFA criteria) and acute kidney failure (based on serum creatinine level) PICU of Ali Bin Abi Taleb Hospital from October 1401 to October 1402 were admitted and hospitalized, they were studied by census method. Within 48 hours after the admission of patients to the ICU, blood samples should be collected to check serum uric acid levels, electrolytes, albumin, complete blood count (CBC), kidney function tests, arterial blood gases, and chest x-rays. All patients were followed up until discharge or death due to progression of kidney failure. Finally, the findings of the research were analyzed using SPSS version 26 statistical software.
RESULTS: The mean age of patients was 3.66±4.92.The expired number in the hyperuricemia group was significantly higher than in the normal uric acid group (p-value = 0.03), an odds ratio of 3.45 indicates that a high level of uric acid is a risk factor for death. In this study, the duration of hospitalization was longer in those who survived (p-value = 0.02). A particularly strong predictor in our analysis was the QSOFA score (p < 0.001), highlighting its critical role in outcome alive or dead. Serum uric acid level and QSOFA scale showed no significant difference, in totally (p-value = 0.76), subgroup analysis from alive and death patients between uric acid and the QSOFA scale presented the same result (p-value = 0.203, p-value = 0.29, respectively) Conclusion: Finally, it can be stated that the level of uric acid can be considered as a laboratory variable to predict the prognosis of patients.
PMID:42251509 | DOI:10.22037/uj.v23i00.8514
