Lasers Med Sci. 2026 Jul 10;41(1):145. doi: 10.1007/s10103-026-04946-w.
ABSTRACT
Fractional microneedle radiofrequency (FMR) has been proven effective and safe for acne scar and skin rejuvenation, but the treatment outcomes vary across different FMR devices. The face of each participant was randomly assigned as treatment side (treated with the Peninsula Timerevert Needle) and control side (treated with the EndyMed) along the midline. Outcome measures include melanin index (MI), erythema index (EI), stratum corneum hydration (SCH), sebum and dermal density on all facial sites. The treatment duration, participant’s satisfaction score and physician’s global assessment (PGA) score, pain score, bleeding score, erythema score and other side effects were evaluated. A total of 20 participants completed the entire course. The participant’s satisfaction score and PGA score increased progressively over time. Compared with the control side, the treatment side exhibited a shorter treatment time and lower pain score, but higher bleeding score. Dermal density increased gradually following FMR treatment and was statistically significant higher at 3 months than that at other follow-up time points. There were no statistically significant differences between the treatment and control sides in participant’s satisfaction score, PGA score, erythema score, erythema duration and edema duration, MI, EI, SCH, sebum and dermal density at the forehead, cheek and chin of at any follow-up time point. FMR is effective and safe for skin photoaging and acne scar. Peninsula Timerevert Needle TM offers the advantages of less pain and shorter treatment duration comparing with EndyMed, but is associated with a higher incidence of bleeding.
PMID:42430070 | DOI:10.1007/s10103-026-04946-w
