J Urol. 2023 Oct 20:101097JU0000000000003765. doi: 10.1097/JU.0000000000003765. Online ahead of print.
ABSTRACT
PURPOSE: To investigate the association between family history of RCC and RCC risk.
MATERIALS AND METHOD: RCC cases diagnosed in Sweden between 2005-2014 and 10 matched controls were identified using Renal Cell Cancer dataBase Sweden, with linkage to the Multigeneration Register and the Swedish Cancer Register. The association between a family history of RCC and RCC was investigated, overall and by sex and age groups.
RESULTS: Among 9416 RCC cases, 294 (3.1%) had 1 or more parent or sibling (first-degree relative, FDR) with RCC. Median age at diagnosis for cases with an affected FDR was 65 years (IQR 59-71) and 68 years (IQR 60-75) for all cases. The proportion of women was significantly higher among familial RCC compared to sporadic RCC (44.6% vs 38.5%, P = .035). RCC was twice as likely with 1 or more FDR with RCC (OR 1.9; CI 1.65-2.16). Stratified analysis showed an OR of 2.4 for women (CI 1.93-2.92) and 1.6 for men (CI 1.35-1.93). Two or more FDRs was associated with a 6-fold increased risk (95% CI 2.37-15.5). Familial RCC was strongly associated with bilateral- and multifocal tumours ([OR 5.5; CI 2.36-13.0], [OR 3.5; CI 1.89-6.49]).
CONCLUSIONS: In this Swedish dataset, 3.1% of RCC patients have 1 or more FDR diagnosed with RCC. There was no statistical difference in median age between sporadic RCC and familial RCC. Having 1 or more FDR with RCC approximately doubles the risk of RCC with a higher risk increase for women than for men. People with 2 FDRs with RCC constitute a small high-risk group that may benefit from screening.
PMID:37862613 | DOI:10.1097/JU.0000000000003765
