J Diabetes Investig. 2021 Jun 15. doi: 10.1111/jdi.13615. Online ahead of print.
ABSTRACT
AIMS/INTRODUCTION: Few people have reported whether there are sex differences in blood lipids and lipid ratios in type 2 diabetic foot (T2DF) patients in China. This paper attempts to identify the contribution to sex-specific differences in blood lipids and lipid ratios in these patients.
MATERIALS AND METHODS: In this case-control study, we explore that 306 patients with T2DF as study group and 306 patients with type 2 diabetes mellitus (T2DM) as control group. Patients were diagnosed according to the Standards of Medical Care in Diabetes-2014 (ADA). Blood lipid and lipid ratios were determined according to the National Cholesterol Education Program Adult Treatment Panel III criteria.
RESULTS: We studied male patients with T2DF who were 68.00 (18.00) years old and females who were 73.50 (19.00) years old; 61.76% of the patients were male. Males had higher BMIs and HbA1c levels than females. Compared to T2DM patients, T2DF patients had significant differences in TC/HDL-C, LDL-C/HDL-C and apoB/apoA-I ratios. HDL-C, TG, apoA-I and apoB/apoA-I ratio were cardiovascular disease (CVD) risk in males, while TC, LDL-C, apoB, and the LDL/HDL-C and TC/HDL-C ratios were better predictors in females. The apoB/apoA-I ratio OR values were 2.18 (95%CI:1.17-4.41) and 2.14 (95%CI:1.14-4.00) in male patients with T2DF before and after adjusting for age respectively (P<0.05).
CONCLUSIONS: T2DF patients present sex-specific differences in their blood lipid and lipid ratios, especially in the apoB/apoA-I ratio, which could be a better indicator for CVD risk.
PMID:34137504 | DOI:10.1111/jdi.13615
