Category: Nevin Manimala

J Cosmet Dermatol. 2026 Mar;25(3):e70755. doi: 10.1111/jocd.70755. Epub 2026 Feb 24.

ABSTRACT

BACKGROUND: Numerous retinoid‐based skincare products are available over‐the‐counter for photodamaged and photoaged skin, but are associated with objective (e.g., erythema, dryness, flaking, edema) and subjective (e.g., itching, tingling, stinging, burning) tolerability issues. A novel retinal formulation was developed using an engineered biomimetic vegan exosome as a delivery system. The formulation also contains proprietary and potent hyaluronic acid, as well as plant‐based actives commonly used in traditional herbal medicines for their anti‐inflammatory and antioxidant properties.

AIMS: Evaluate the efficacy and tolerability of this biomimetic exosome‐encapsulated retinal product for treatment of mild‐to‐moderate facial photodamage.

PATIENTS/METHODS: Twenty females aged 35 to 65 years, with Fitzpatrick skin types I‐VI, mild‐to‐moderate facial fine lines and wrinkles, and mild‐to‐moderate facial photodamage, were assessed at screening/baseline and weeks 2, 4, 8, and 12. Investigator‐ and participant‐assessed evaluations were performed at each visit. The primary objective was to demonstrate a decrease in the appearance of fine lines and wrinkles, erythema, as well as a reduction of overall facial photodamage after a 12‐week topical regimen. The secondary objective was to measure the frequency of adverse events throughout the study.

RESULTS: Statistically significant improvements in erythema, skin tone, skin texture, and lines/wrinkles were observed at all follow‐up visits, compared to baseline. At weeks 8 and 12, all participants (100%) displayed improvements in facial aesthetics. Most participants (19/20; 95.00%) were satisfied with the product and would recommend it to others. No product‐related adverse events were reported.

CONCLUSIONS: Daily use of this “hydrating retinal” improved signs of facial photodamage with none to mild signs of skin irritation.

PMID:41735774 | PMC:PMC12932260 | DOI:10.1111/jocd.70755

Sports Med Open. 2026 Feb 24;12:14. doi: 10.1186/s40798-026-00987-1. eCollection 2026 Dec.

ABSTRACT

BACKGROUND: Rugby union is a popular contact sport during which high impact collisions frequently occur. There is concern for the overall brain health of those playing the game, as concussion is a potential outcome of high impact collisions. Repeated sub-concussive collisions may compromise rugby players’ neurological integrity, but little is known about the effects on young brains. The brain is still developing during adolescence and may generally be more susceptible to injury, but minimal objective research data are available regarding head acceleration events experienced by junior players.

RESULTS: Forty-one adolescent male rugby players underwent pre- and post-season MRI scans and neuro-cognitive assessments. Participants were fitted with instrumented mouthguards to record head acceleration events experienced during the season. Post-season processing of MRI scans focused on within-subject analysis of pre- to post-season changes in white matter as measured by diffusion tensor imaging. Linear mixed models were used to investigate correlations between neurological changes and cumulative head impact loading recorded by the mouthguards. MRI results indicated a non-significant difference between pre- and post-season for data relating to brain structure and function, including white matter microstructure, in response to one season of contact training and match play for under-16 male rugby players, as measured by diffusion tensor imaging. These results held irrespective of level of exposure.

CONCLUSIONS: Our data suggest that exposure to one season of rugby does not appear to result in neurological compromise. The statistical non-significance reported for the main outcome measure also held when controlling for variables, such as training age and headgear use. Although pre- to post-season differences were statistically non-significant, the long-term effects of high exposure may be of clinical significance going forward. Further research, particularly using longitudinal designs, is needed to further elucidate the potential for microstructural neurological changes in adolescent rugby players.

SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40798-026-00987-1.

PMID:41733814 | PMC:PMC12932775 | DOI:10.1186/s40798-026-00987-1

Ann Noninvasive Electrocardiol. 2026 Feb 24;31(2):e70162. doi: 10.1111/anec.70162. eCollection 2026 Mar.

ABSTRACT

OBJECTIVE: This study compared the accuracy of three transthoracic echocardiographic (TTE) techniques—fractional shortening (FS), left ventricular outflow tract velocity‐time integral (LVOT/VTI), and Simpson’s method—for measuring cardiac output (CO) and stroke volume (SV) in hemodynamically unstable patients (systolic pressure < 90 mmHg), using pulse index continuous cardiac output (PiCCO) as the reference.

METHODS: A retrospective analysis was conducted involving 12 patients admitted to an Emergency Intensive Care Unit between October 2023 and October 2024, who underwent a total of 54 echocardiographic examinations. The median length of hospital stay is 14 days. CO and SV values obtained using the three TTE methods as part of routine assessment were compared with simultaneous PiCCO measurements. The median number of examinations for patients is 4. Statistical analysis was performed using correlation methods.

RESULTS: All three TTE methods demonstrated the capability to estimate CO and SV. The VTI method showed the highest overall accuracy (CO‐VTI vs. CO‐PiCCO: r = 0.950, p< 0.001). Under reduced CO conditions, correlations between echocardiographic and PiCCO‐derived measurements decreased for all methods; however, the VTI method maintained superior reliability (r = 0.606, p = 0.006). In contrast, the Simpson’s method did not accurately reflect CO in this setting (SV‐Simpson vs. SV‐PiCCO: r = 0.408, p = 0.083). Notably, the performance of the VTI method remained consistent regardless of SV or heart rate variations (SV‐VTI vs. SV‐PiCCO: overall r = 0.970; with heart rate > 100 bpm, r = 0.946; with heart rate ≤ 100 bpm, r = 0.988).

CONCLUSION: The LVOT/VTI method exhibits the highest accuracy and consistency for measuring SV and CO, making it the preferred non‐invasive technique for hemodynamic evaluation in critically ill patients.

PMID:41735802 | PMC:PMC12932115 | DOI:10.1111/anec.70162

Australas J Dermatol. 2026 Feb 24. doi: 10.1111/ajd.70076. Online ahead of print.

ABSTRACT

BACKGROUND/OBJECTIVES: The Royal Brisbane & Women’s Hospital (RBWH) in Queensland, Australia provides definitive care for all diagnosed adult patients with SJS/TEN within its catchment. In this retrospective cohort study, we identified all SJS/TEN cases at RBWH over a 10-year period. We assessed disease incidence and the relationship of 3 variables (disease severity, time taken to admission to the definitive tertiary centre and systemic immunosuppressive treatment) to the outcome of mortality.

METHODS: Patients were identified via ICU MetaVision dermatology entries, discharge coding and manual admission recording. Age, gender, culprit drug, time to definitive tertiary centre admission, total body surface area (TBSA), SCORTEN, complications, systemic therapy utilisation and mortality were recorded. Relationships between variables were analysed using Spearman’s Rank correlations and logistic regression.

RESULTS: Fifty-two cases over 10 years met inclusion criteria (37 TEN, 8 SJS/TEN and 7 SJS). Mortality (9.6%; 5 deaths) was low compared to published rates. Multivariate regression analysis revealed a significant relationship between increased SCORTEN and mortality as expected. There was no significant relationship between systemic treatment and mortality or between ‘days to definitive care’ and mortality. Modelling accounted for 44% of variance in mortality.

CONCLUSIONS: SJS/TEN incidence matched published rates. Severity of SJS/TEN and mortality were correlated. Neither systemic immune suppression nor time taken to be admitted to the definitive tertiary centre correlated with mortality. Expert multidisciplinary care in the RBWH ICU and Burns Unit is likely to contribute to the excellent mortality outcomes found. Limitations of the study included its retrospective cohort design, that it was performed in a single centre, and the relatively small sample size leading to statistically insignificant findings. Our results should bolster growing data to improve understanding of this rare but serious condition.

PMID:41736175 | DOI:10.1111/ajd.70076

Diabetol Metab Syndr. 2026 Feb 24. doi: 10.1186/s13098-026-02107-1. Online ahead of print.

ABSTRACT

OBJECTIVE: This study evaluated the effects of intensive lifestyle modification (ILM) incorporating calorie-carbohydrate restriction (CCR) with or without time-restricted feeding (IFCCR) on psychological health in adults with type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS: In a 24-week randomized controlled trial, 120 adults with T2D were allocated to CCR (n = 40), IFCCR (n = 40), or a control group (n = 40). Both intervention arms followed an energy-restricted diet (1000-1200 kcal/day), received behavioral support, and performed ≥ 150 min/week of physical activity. The IFCCR group additionally restricted eating to an 8-hour daily window. Primary and secondary outcomes were eating disorder psychopathology (EDE-Q scale) and diabetes-related distress (PAID scale), respectively.

RESULTS: Both CCR and IFCCR significantly reduced diabetes-related distress compared to the control (CCR: β = -1.80, p = 0.007; IFCCR: β = -1.78, p = 0.01). EDE-Q scores also improved significantly. Improvements were observed across EDE-Q subscales, particularly in weight and shape concern. After adjustment for changes in weight and HbA1c, reductions in PAID became non-significant, while improvements in several EDE-Q domains, particularly in the IFCCR group, remained significant. IFCCR showed numerically greater reductions than CCR, though differences were not statistically significant. The control group demonstrated minimal changes.

CONCLUSIONS: Intensive lifestyle modification incorporating CCR or IFCCR improved eating disorder psychopathology, whereas reductions in diabetes-related distress appear largely related to metabolic changes. These findings support the integration of structured dietary and behavioral interventions into diabetes care.

TRIAL REGISTRATION: This trial was registered in Iranian Registry of Clinical Trials (IRCT), IRCT20230917059447N1 (https//irct.behdasht.gov.ir/trial/72666).

PMID:41736129 | DOI:10.1186/s13098-026-02107-1

J Anesth Analg Crit Care. 2026 Feb 25. doi: 10.1186/s44158-026-00362-2. Online ahead of print.

ABSTRACT

INTRODUCTION: Blood purification techniques are being investigated as adjunctive options in critically ill patients not only to treat severe inflammation but also to remove harmful substances such as myoglobin in rhabdomyolysis. Yet, the available evidence is limited, and further research is needed to clarify their clinical benefits.

METHODS: The international prospective COSMOS Registry (NCT05146336, 23 Nov 2021) tracks CytoSorb® (CS) utilization patterns and outcomes in critical care settings. Clinical assessment was performed before, during, and after CS treatment, with a 90-day follow-up. Device-related adverse effects were reported by investigators as the safety evaluation. Data were analyzed according to a pre-specified statistical plan using descriptive statistics and paired tests to compare pre- and post-treatment values, with subgroup and safety analyses performed.

RESULTS: A total of 300 adult patients (30.3% female, mean age 59 ± 15 years) from 22 sites were included in this analysis. The most common indications for CS therapy (multiple indications possible per patient) were septic shock (48.3%), rhabdomyolysis (12.8%), cardiogenic shock (11.5%), liver failure (11.5%), and acute respiratory distress syndrome (ARDS; 5.0%). On average, each patient received 3.3 ± 3.3 adsorbers, with 27.9% of patients receiving 4 or more adsorbers. CS was integrated in conjunction with kidney replacement therapy (75.6%), standalone hemoperfusion (7.1%), intermittent hemodialysis (IHD; 10.6%), extracorporeal membrane oxygenation (ECMO; 3.9%), and sustained low-efficiency daily dialysis (SLEDD; 4.9%). At baseline, median (interquartile range, IQR) APACHE II and SOFA scores were 24 [18, 30] and 12 [9, 15], respectively. Fluid balance improved from +1675 [141, 3348] mL pre-CS to +115 [-1100, 1495] mL post-CS, and norepinephrine requirements decreased from 0.21 [0.09, 0.40] µg/kg/min to 0.08 [0.02, 0.22] µg/kg/min (p < 0.0001 for both). Ratio of partial pressure of oxygen in arterial blood to the fraction of inspiratory oxygen concentration (P/F ratio) improved from 120 [72, 208] to 176 [115, 255] (p < 0.0001). Platelet counts decreased from 123 [76, 185] to 72 [42, 118] × 10⁹/L (p < 0.0001), while albumin levels remained stable from 2.6 [2.3, 3.1] to 2.5 [2.3, 3.0] g/dL (p = 0.112). ICU mortality was 33.1%, which was lower than mortality estimates historically associated with comparable APACHE II and SOFA scores. No serious adverse effects related to the device or device deficiencies were reported.

CONCLUSIONS: Real-world CytoSorb® use as part of standard care in critically ill patients was associated with improvements in several clinical and laboratory parameters; however, these findings should be interpreted cautiously given the observational design and absence of a control group. Observed mortality was lower than mortality estimates historically associated with established severity scores.

PMID:41736101 | DOI:10.1186/s44158-026-00362-2

Genome Biol. 2026 Feb 25. doi: 10.1186/s13059-026-04006-0. Online ahead of print.

ABSTRACT

BACKGROUND: Machine learning models in biomedical research are often hindered by demographic imbalances in clinical datasets, leading to biased predictions that disadvantage minority populations. Existing bias-correction methods face limitations in handling the heterogeneity of biomedical data and the complexity of demographic influences.

RESULTS: We present DeBias, a computational framework for mitigating demographic biases in high-dimensional biomedical datasets. DeBias identifies and removes bias-associated subspaces from the feature space using control samples, enabling global correction of demographic distortions while preserving disease-specific signals. To evaluate its effectiveness, we apply DeBias to cell-free DNA methylation data for cancer detection. DeBias achieves a significant reduction in the number of features exhibiting demographic bias and outperforms existing methods in improving cancer detection performance for minority populations. Performance gains are validated in independent cohorts, highlighting the robustness of the approach.

CONCLUSIONS: DeBias offers an effective and generalizable strategy for correcting demographic biases in biomedical machine learning. It represents a step toward more equitable machine learning models that can deliver reliable and unbiased predictions across diverse patient populations.

PMID:41736096 | DOI:10.1186/s13059-026-04006-0

Int J Behav Nutr Phys Act. 2026 Feb 25. doi: 10.1186/s12966-026-01898-w. Online ahead of print.

NO ABSTRACT

PMID:41736085 | DOI:10.1186/s12966-026-01898-w

Chiropr Man Therap. 2026 Feb 24;34(1):5. doi: 10.1186/s12998-026-00627-1.

ABSTRACT

BACKGROUND: Injuries sustained during healthcare consultations are a significant concern, and compensation claims relating to injuries in health systems are increasing. Extensive research has addressed injuries in the secondary sector, whereas knowledge about injuries sustained in primary care remains sparse. This retrospective register-based study aimed to describe compensation claims involving chiropractors in Denmark between 2013 and 2022.

METHODS: All claims related to chiropractors from 2013 to 2022 were accessed in the Danish Patient Compensation Association Register and analyzed using the Healthcare Complaints Analysis Tool. Data on patient characteristics, injuries, processing time, decisions, appeals, and financial compensation were collected. Claims were categorized as relating to clinical, management, or patient-clinician relationship, alongside nine symptom-based injury classifications. Data relating to cervical artery dissection were examined separately and in greater detail, including information on presenting symptoms, International Classification of Primary Care, Second Edition code recorded by the chiropractor, treatment modalities used, time from treatment to onset of symptoms, and type of vascular injury subsequently diagnosed. Descriptive statistics summarized findings.

RESULTS: A total of 535 chiropractor-related claims were identified, with 519 included for analysis. The number of claims per 100,000 consultations increased from 1.03 in 2013 to 3.57 in 2022. Most claims (84%) concerned treatment outcomes and side effects, primarily worsening of symptoms (23%) or delayed referral (23%). Of the 519 claims, only 32 (6%) were approved for compensation. Cervical artery dissection-related claims had the highest approval rate within category (29%; ~ 0.7 approved claims per million consultations) and accounted for 94% of total financial compensation (14 approved claims, 3,025,000 €).

CONCLUSION: Compensation claims related to chiropractic care in Denmark increased between 2013 and 2022, but approval rates remained low. Most claims concerned dissatisfaction with treatment outcome or worsening of symptoms. Cervical artery dissection-related claims had the highest approval rate and accounted for the highest compensation. When approved, they were compensated based on the fairness rule stating that the outcome could neither have been predicted nor expected from patients’ individual cases. Better communication between patients and chiropractors about expectations for treatment, natural course of conditions, and expected reactions to treatment will likely reduce the number of claims.

PMID:41736054 | DOI:10.1186/s12998-026-00627-1

Ital J Pediatr. 2026 Feb 24. doi: 10.1186/s13052-026-02216-7. Online ahead of print.

NO ABSTRACT

PMID:41736052 | DOI:10.1186/s13052-026-02216-7