Category: Nevin Manimala

Eur J Radiol. 2026 Feb 11;197:112698. doi: 10.1016/j.ejrad.2026.112698. Online ahead of print.

ABSTRACT

OBJECTIVES: Adenomyomatosis (ADM) is generally considered a benign condition. However, it can be associated with chronic cholecystitis – a known risk factor for gallbladder cancer. Therefore, studies have proposed follow-up with ultrasound for asymptomatic patients with focal ADM. Currently, there are no formal recommendations regarding the frequency and length of follow-up. The aims of this study were to assess the growth of ADM lesions during follow-up and to examine the differences between larger and smaller ADM lesions.

METHODS: 144 patients who underwent MRI-MRCP at our institution between the years 2014-2024 were identified through radiological reports as having a diagnosis of ADM. 43 patients had more than one examination. Demographic, clinical and radiological data were collected retrospectively. We divided the cohort into two groups based on the primary lesion size (axial diameter below or above 1.5 cm) and compared between them.

RESULTS: The group of small lesions included 98 patients and the larger lesions group included 46 patients. We did not find a statistically significant correlation between the size of. ADM and the demographic or clinical characteristics examined. Only 9 ADM lesions grew during follow-up – 6 from the smaller lesions group and 3 from the large lesions group (p > 0.05). The median follow-up period was 35 months. None of our patients developed gallbladder carcinoma.

CONCLUSIONS: Our results confirm the common hypothesis that ADM are benign lesions. Therefore, we believe that follow-up is not needed for lesions with a clear diagnosis of focal ADM.

PMID:41691732 | DOI:10.1016/j.ejrad.2026.112698

Eur J Obstet Gynecol Reprod Biol. 2026 Feb 12;320:115006. doi: 10.1016/j.ejogrb.2026.115006. Online ahead of print.

ABSTRACT

INTRODUCTION: This study aimed to evaluate the expression of selected immunohistochemical (IHC) markers and serum squamous cell carcinoma antigen (SCC-Ag) in vulvar squamous cell carcinoma (VSCC), and to investigate associations with recurrence and death using molecular clustering and diagnostic performance analyses.

STUDY DESIGN: This single-centre prospective study included 27 patients with histologically confirmed VSCC. Tumour specimens were assessed for expression of p16, p53, programmed death-ligand 1 (PD-L1), CD44 and epidermal growth factor receptor (EGFR). Serum SCC-Ag was measured and correlated with clinical outcomes. Statistical analyses comprised Pearson’s correlation, logistic regression, receiver operating characteristic curve analysis, diagnostic performance metrics, and unsupervised hierarchical clustering integrating IHC and SCC-Ag data.

RESULTS: No significant associations were observed between individual IHC markers and clinical outcomes. Serum SCC-Ag showed a positive trend towards association with recurrence (r = 0.462; p = 0.071), with an increased odds ratio (OR) (OR = 2.7). When analysed as a binary variable, SCC-Ag demonstrated sensitivity of 50%, specificity of 76%, and overall accuracy of 70%. As a continuous variable, SCC-Ag achieved an area under the curve value of 0.83. The combination of SCC-Ag and p53 improved sensitivity to 83% and negative predictive value to 89%. Unsupervised hierarchical clustering identified three biological subgroups, with the cluster characterized by high SCC-Ag and EGFR expression and low p16 expression associated with recurrence more frequently.

CONCLUSION: Serum SCC-Ag showed superior prognostic performance compared with individual IHC markers, and may be useful for postoperative risk stratification in VSCC. Combined biomarker panels, including p53, PD-L1, EGFR and p16, yielded promising sensitivity, supporting future strategies.

PMID:41691727 | DOI:10.1016/j.ejogrb.2026.115006

Eur J Obstet Gynecol Reprod Biol. 2026 Feb 5;320:114990. doi: 10.1016/j.ejogrb.2026.114990. Online ahead of print.

ABSTRACT

OBJECTIVE: Urinary incontinence is a common issue yet frequently overlooked in patients with endometrial cancer, especially post-treatment. Both advanced age and obesity as shared risk factors for endometrial cancer and urinary incontinence compound this burden. We hypothesized that there is insufficient awareness and suboptimal integration of urinary incontinence management into endometrial cancer care.

METHODS: The European Network of Young Gynaecologic Oncologists (ENYGO) team conducted a cross-sectional online survey from February to November 2024 using SurveyMonkey, targeting healthcare professionals involved in gynecologic oncology care. The 31-item questionnaire covered demographics, diagnostics, treatment protocols, and urinary incontinence-related practices. Statistical analysis was performed using SPSS V28.0, including descriptive statistics, normality testing, and appropriate reporting of mean ± SD or median with interquartile ranges.

RESULTS: Our final analysis included 85 complete responses. Respondents were from 31 countries, with a median age of 38 years, and 55.3% of them were female. Although 65.9% of institutions had urogynecologists, only 3.5% of respondents had formal urogynecology training. Urinary incontinence was most frequently discussed before surgery (27.1%) and least before targeted therapy (9.4%). Radiation therapy was identified by 75.4% as the main contributor to urinary incontinence. While 96.5% asked about urinary incontinence during follow-up, only 14.1% managed it post-treatment. Major barriers included lack of training (54.1%) and resources (31.8%). Notably, 58.8% expressed interest in further training.

CONCLUSION: Despite high reported awareness of urinary incontinence, proactive assessment and management remain inconsistent in endometrial cancer care. Structured education, interdisciplinary collaboration, and guideline development are needed to optimize quality of life outcomes.

PMID:41691725 | DOI:10.1016/j.ejogrb.2026.114990

J Surg Educ. 2026 Feb 14;83(5):103885. doi: 10.1016/j.jsurg.2026.103885. Online ahead of print.

ABSTRACT

OBJECTIVE: Entrustable professional activities (EPAs) have been embraced by the medical education community as a framework to guide competency-based education systems. The Vascular Surgery Board and Association for Program Directors in Vascular Surgery collaborated on the development of 15 vascular surgery EPAs, covering the core clinical activities of a vascular surgeon. We sought to explore engagement and perceptions of feasibility and utility of EPA assessment implementation for participants in a national, multi-institutional pilot.

DESIGN: Faculty assessment and trainee self-assessment of 15 vascular surgery EPAs were rated on a 4-point entrustment scale: 1 = limited participation, 2 = direct supervision, 3 = indirect supervision, and 4 = practice-ready, with accompanying behavioral anchors describing the actions expected of a learner at each level. Following an introductory webinar, the American Board of Surgery EPA Application assessment tool (delivered via SIMPL) was provided to all participating programs. Surveys evaluating the perceived feasibility and utility of the EPAs were developed. The surveys were distributed to pilot participants via email in June 2024 and responses were collected using Qualtrics. For Likert-scale items, descriptive statistics were calculated. For open-ended responses, thematic analysis was conducted to explore perceptions of respondents. This retrospective cohort study received an exemption determination from the University of Utah Institutional Review Board prior to the initiation of study procedures.

SETTING: This was a national, multi-institutional study. Participating programs included both academic, community, and hybrid programs.

PARTICIPANTS: Thirty institutions (22 fellowship, 27 residency programs) participated in the pilot. Post-pilot surveys were completed by 89 participants, including 22 program directors (Response rate 73%), 13 program managers (Response rate 43%), 26 trainees, and 28 faculty.

RESULTS: A total of 2746 EPA assessments were completed by faculty and trainees during the pilot. Regarding ease of integration of EPA assessments into perioperative workflow, 92% of trainees and 96% of faculty had neutral or positive responses. Eight four percent of trainees agreed that they were comfortable initiating EPA assessments. Seventy seven percent of trainees felt that EPA data would help them to set learning goals and 77% felt that EPA assessments helped them identify areas for improvement. For faculty, 74% felt the EPA assessments helped them identify topics on which to provide feedback.

CONCLUSIONS: This study demonstrates the feasibility and utility of EPA workplace-based assessment implementation at a diverse subset of vascular surgery training programs. Integration into usual clinical workflow was viewed as easy by both faculty and trainees. Furthermore, trainees felt the assessments were helpful to their learning, and faculty felt the assessment anchors helped them give meaningful feedback to trainees. These findings support an overall positive reception to EPA assessments in vascular surgery.

PMID:41691722 | DOI:10.1016/j.jsurg.2026.103885

Comp Immunol Microbiol Infect Dis. 2026 Feb 11;126:102450. doi: 10.1016/j.cimid.2026.102450. Online ahead of print.

ABSTRACT

Cystic echinococcosis (CE), caused by Echinococcus granulosus sensus lalo (E. granulosus s.l.), remains a major zoonotic and economic concern in Algeria. This systematic review and meta-analysis aimed to estimate the national prevalence of CE in domestic animals, identify spatial patterns, and evaluate factors contributing to epidemiological variability. Literature searches were performed across nine international and regional databases, and eligible studies published between 2003 and 2024 were screened following PRISMA guidelines. A total of 22 studies were included, yielding 68 independent prevalence estimates from 20 Algerian regions. Study quality was assessed using the Joanna Briggs Institute (JBI) checklist, and statistical analyses including random-effects models, meta-regression, and spatial autocorrelation were conducted in R. Among definitive hosts (dogs), the pooled prevalence was 15.24 % (95 % CI: 4.52-40.61 %; k = 4), with substantial heterogeneity (I² = 94.7 %). For intermediate hosts, analysis of 763,662 animals revealed an overall pooled prevalence of 4.16 % (95 % CI: 2.59-6.63 %), with marked inter-species variability: cattle (12.44 %), camels (7.81 %), sheep (6.31 %), goats (5.21 %), and wild boars (6.32 %). After applying the trim-and-fill method to account for potential missing studies, the adjusted pooled prevalence was 6.42 %. Significant regional disparities were identified, with hyperendemic clusters in Tébessa, M’Sila, and Setif, contrasted with low-risk zones such as Tindouf and Batna. Spatial analysis detected significant positive autocorrelation (Global Moran’s I = 0.273; p = 0.033), indicating geographical clustering. Meta-regression revealed sample size and geographic location as key moderators of heterogeneity. This study provides the most comprehensive synthesis of CE prevalence in Algerian livestock to date, highlighting persistent endemicity and spatial hotspots. Findings emphasize the need for strengthened One-Health surveillance, targeted control strategies, and standardized diagnostic protocols to reduce transmission risk and associated economic losses.

PMID:41691718 | DOI:10.1016/j.cimid.2026.102450

Curr Cardiol Rev. 2026 Feb 12. doi: 10.2174/011573403X421729251114113706. Online ahead of print.

ABSTRACT

INTRODUCTION: Cardiovascular diseases (CVDs) remain the leading cause of global mortality, with congenital heart disease (CHD), acquired heart disease (AHD), valvular disorders, and cardiomyopathies contributing significantly to morbidity. Retinal fundus imaging has emerged as a non-invasive modality capable of capturing microvascular alterations that may serve as biomarkers for systemic cardiovascular dysfunction.

METHODS: This review systematically examined literature published between 2015 and 2025 on the use of retinal fundus imaging for predicting structural heart diseases. Databases including PubMed, Scopus, and Web of Science were searched using predefined keywords. Studies were evaluated according to disease focus, imaging modality, analytical methods, and diagnostic performance.

RESULTS: Findings highlight that deep learning and machine learning models applied to retinal fundus images have demonstrated promising accuracy in detecting and classifying CVDs. Convolutional neural networks achieved up to 91% AUC for CHD detection, while hybrid multimodal approaches improved sensitivity in AHD and valvular disease prediction. Cardiomyopathies were associated with vessel tortuosity and microhemorrhages, quantifiable through automated image analysis. Table 1 provides a statistical summary of performance across studies.

DISCUSSION: Emerging approaches, such as transformer-based models and adaptations of the Segment Anything Model (SAM) for medical imaging, offer potential for improving generalizability and interpretability. Challenges remain, including dataset imbalance, limited longitudinal validation, and the black-box nature of AI models.

CONCLUSION: Retinal imaging holds strong potential as a scalable, non-invasive tool for cardiovascular disease prediction. Integrating advanced AI architectures may enhance diagnostic accuracy and accelerate translation into clinical practice.

PMID:41691690 | DOI:10.2174/011573403X421729251114113706

Curr Med Imaging. 2026 Feb 13. doi: 10.2174/0115734056444403260202075613. Online ahead of print.

ABSTRACT

INTRODUCTION: This study aims to evaluate reference ranges for SPECT Myocardial Perfusion Imaging (MPI) parameters using Myoview® (tetrofosmin) radiopharmaceutical and Myovation® processing software. This study also aims to provide a reference range for future MPI quantitative studies in patients with suspected heart disease and to identify significant variables associated with an abnormal left ventricular ejection fraction.

METHODS: Data were retrospectively collected from 1,100 MPI studies (2017-2024) with 932 participants included after excluding poor-quality images. Imaging was performed using a GE SPECT/CT Optima NM/CT640 camera, and images were reconstructed using the OSEM algorithm (Myovation®). Volumetric and quantitative parameters were extracted for analysis (e.g., Left Ventricular Ejection Fraction (LVEF), End-Systolic Volume (ESV), End-Diastolic Volume (EDV), Stroke Volume (SV), and dyssynchrony parameters). Reference ranges were derived using descriptive statistics, and comparative analyses examined how parameters varied by sex and age. Regression analysis and Receiver Operating Characteristic (ROC) curves were used to assess the relationship between abnormal LVEF and dyssynchrony indices.

RESULTS: The study analysed 932 participants under stress and 462 at rest, yielding adequate statistical power. Average LVEF was 68% in both conditions. At stress, mean EDV was 95.1 mL and mean ESV was 34.7 mL; corresponding values at rest were 104.8 mL and 40.1 mL. Diagnosis significantly influenced all volumetric and dyssynchrony parameters at rest and during stress (all p < 0.001), showing progressive ventricular dilation, reduced LVEF, and increased dyssynchrony from the normal to the ischemic and infarcted groups. Sex significantly affected LVEF and ventricular volumes, with females exhibiting higher LVEF and smaller volumes, while age had minimal effects. Resting dyssynchrony indices correlated strongly with stress LVEF, particularly in diseased groups. Logistic regression demonstrated good discrimination (AUC = 0.80) and calibration, identifying resting volumetric and clinical factors as independent predictors of abnormal stress LVEF.

DISCUSSION: This study defines sex- and age-specific reference ranges for gated SPECT MPI-derived ventricular function in a Kuwaiti population. Ventricular volumes, systolic function, and dyssynchrony varied significantly by sex and diagnosis, with progressive impairment across disease groups. Logistic regression analysis with multiple variables identified resting volumetric indices and demographic characteristics, rather than dyssynchrony measures, as the primary independent predictors of abnormal left ventricular function during stress. The model demonstrated good discriminatory ability and calibration.

CONCLUSION: Sex- and age-specific reference ranges for gated SPECT MPI reveal clinically meaningful variation in ventricular function and dyssynchrony by diagnosis. Logistic regression findings indicate that conventional ventricular volumes and patient characteristics primarily drive stress systolic impairment, while dyssynchrony indices offer complementary but not independent prognostic value.

PMID:41691673 | DOI:10.2174/0115734056444403260202075613

Curr Med Imaging. 2026 Feb 11. doi: 10.2174/0115734056407923251129144547. Online ahead of print.

ABSTRACT

Introduction The Breast Imaging Reporting and Data System (BI-RADS) category 4 is subdivided into 4A, 4B, and 4C to reflect varying levels of suspicion for malignancy. However, the predictive consistency of these subcategories remains debated, especially in underrepresented populations. This study aims to assess the correlation between BI-RADS 4 subcategories and histopathological outcomes in Mexican women, identifying additional demographic and imaging predictors of malignancy. Materials and Methods This retrospective cross-sectional study included 173 female patients with BI-RADS 4 lesions who underwent mammography and/or ultrasound, followed by histopathological confirmation. Data were collected from the Hospital General de México between January 2023 and May 2024. Associations between BI-RADS subcategories and malignancy, age, lesion laterality, and imaging features were analyzed using chi-square tests and ANOVA.

RESULTS: Among 173 patients, 41.6% had BI-RADS 4A lesions, 35.8% had 4B, and 22.5% had 4C. Malignancy rates increased progressively across subcategories: 7.5% (4A), 40.0% (4B), and 85.0% (4C) (p < 0.001). The mean age rose with BI-RADS level (42.1, 47.8, and 55.3 years for 4A, 4B, and 4C, respectively), although this trend was not statistically significant (p = 0.063). Nodules were the most frequent imaging finding (83.2%), and fibroadenomas were the most common benign diagnosis. Left-sided lesions were more frequently malignant (p = 0.034).

DISCUSSION: The BI-RADS 4 subcategorization showed a clinically meaningful, although not statistically significant, trend in malignancy risk. Lesion laterality emerged as a potential independent predictor of malignancy, warranting further investigation. The findings reinforce the complementary role of demographic and imaging variables in risk assessment.

CONCLUSION: The BI-RADS 4 subclassification aligns with increasing malignancy risk, supporting its clinical utility. However, variability in diagnostic outcomes suggests the need to integrate histopathological and demographic data. Lesion laterality may represent a novel factor in malignancy prediction among breast lesions. Sustainable Development Goals (SDGs) Keywords SDG 3 Good Health and Well-being; SDG 5 Gender Equality; SDG 10 Reduced Inequalities; SDG 9 Industry Innovation and Infrastructure; SDG 4 Quality Education; SDG 17 Partnerships for the Goals.

PMID:41691672 | DOI:10.2174/0115734056407923251129144547

Curr Med Imaging. 2026 Feb 2. doi: 10.2174/0115734056427749260108092529. Online ahead of print.

ABSTRACT

INTRODUCTION: This study aimed to evaluate the impact of varying slice thickness on quantitative values using the Magnetic Resonance Image Compilation (MAGiC) sequence.

METHODS: In this retrospective study, 23 healthy subjects underwent the MAGiC sequence (at 3.0 T) with three slice thicknesses: 3 mm (TH3), 4 mm (TH4), and 5 mm (TH5). The T1, T2, and PD values were measured in various knee joint cartilage regions by two experienced radiologists, including the lateral femoral condyle (LFC), lateral tibial plateau (LTP), medial femoral condyle (MFC), medial tibial plateau (MTP), patella (PAT), and trochlea (TRO). The effects of varying slice thicknesses (TH4 vs. TH3 and TH5 vs. TH3) were analyzed using paired t-tests or Wilcoxon signed rank tests, with statistical significance set at P < 0.025. Intra-rater and inter-rater reliability were also assessed.

RESULTS: Measurements of T1, T2, and PD values demonstrated high intra- and inter-rater reliability. Minimal differences were observed across slice thicknesses for T1WI, T2WI, and PDWI images. T2 and PD values showed little variation, while T1 mapping revealed significant differences. T2 values were consistent across regions, except for the LFC.

DISCUSSION: TH4 and TH5 can replace TH3 for knee joint scanning while reducing scan time, with minimal differences in anatomical depiction across sequences. MAGiC technology significantly improves efficiency by acquiring quantitative data in a single scan, demonstrating stable T2 values unaffected by slice thickness, though T1 and PD values are thickness-dependent. This technique holds clinical value for cartilage injury assessment but requires further research on the applicability of multiplanar imaging.

CONCLUSION: T2 values obtained with the MAGiC sequence are stable across TH3, TH4, and TH5, allowing for reliable cartilage T2 quantification using TH5 to reduce patient scan time.

PMID:41691665 | DOI:10.2174/0115734056427749260108092529

Vet Med Sci. 2026 Mar;12(2):e70845. doi: 10.1002/vms3.70845.

ABSTRACT

Athene noctua, commonly known as the little owl, thrives across the warmer climates of Europe, Asia and North Africa. One of the anatomical features of birds is the presence of a bony scleral ring in the eye. In avians, this configuration comprises ossicles that are affixed together in diminutive plates and are not articulated to other components of the skeleton. The morphology, number, development and location of the scleral ring vary among different vertebrate groups. The objective of this research is to furnish a comprehensive elucidation of the morphology of the scleral ring in the A. noctua predicated on CT scan results and anatomical examination. The overall shape of the scleral ring, the number and shape of the ossicles and their positioning and extensions are notable features that can be used for classification purposes. The study population comprised 10 adult owls (five male and five female). Micro-CT scan, CT scan, ultrasound, radiography and morphometric analysis were used for these owls. The results indicated that the scleral ring in the owls consisted of 15 ossicles, arranged in quadrilateral and rectangular shapes. In one sample, the right eye ring of the owl contained 16 ossicles, which was considered an exceptional feature. The ring consisted of two parts: an anterior tubular section and a posterior conical section. Morphometric analysis showed significant differences between male and female owls in various measurements. SUMMARY: Ossicle Composition: The scleral ring in Athene noctua predominantly consists of 15 quadrilateral ossicles, with a rare anatomical variation of 16 ossicles observed unilaterally in one specimen. Structural Morphology: The ring displays a distinct bipartite architecture, featuring an anterior tubular segment with a near-circular cross-section and a posterior funnel-shaped segment with oval cross-section. Sexual Dimorphism: Morphometric analysis revealed statistically significant (p < 0.05) larger ocular dimensions in female specimens compared to males most measured parameters. Absence of Sesamoid Bone: Unlike other strigiform species, no sesamoid ossification or tubercular structures were observed adjacent to the scleral ring. Taxonomic and Clinical Relevance: These findings provide (1) diagnostic markers for ocular trauma assessment and (2) potential phylogenetic discriminators within Strigiformes.

PMID:41691642 | DOI:10.1002/vms3.70845