Category: Nevin Manimala

Genetica. 2022 Nov 24. doi: 10.1007/s10709-022-00175-5. Online ahead of print.

ABSTRACT

The geographic range of a species is crucial for obtaining information on the exact distribution of the species. The geographic data are important for delimiting distinct species or exploring the degree of differentiation among different populations of a species. The local details of species boundaries facilitate the study of the importance of phylogeographic background, secondary contacts, and hybrid zones, along with the relations between the species and its extrinsic environmental factors. In the present study, the range boundaries of Bufo bufo and Bufo verrucosissimus in the north-eastern region of Türkiye were delineated using an integrative taxonomic approach that utilized a combination of molecular and morphological data. According to the mtDNA results of the present study, B. bufo inhabits a single distribution from İyidere town to Çayeli town in Rize, while B. verrucosissimus is distributed from Şavşat town of Artvin to Ardeşen town in Rize. In addition, the two species coexist in Pazar, Hemşin, and Çamlıhemşin towns in Rize. The demographic analyses indicated a distinct population expansion for the B. verrucosissimus species after the Last Glacial Maximum, while the same did not occur for B. bufo. The univariate and multivariate statistical analyses conducted for the morphological data of the two species corroborated the presence of a putative contact zone between B. bufo and B. verrucosissimus. In summary, the present study resolved the non-distinct geographic boundaries between B. bufo and B. verrucosissimus species and also revealed the easternmost distribution of B. bufo in Türkiye. In addition, important evidence on the putative contact zone between the two species was indicated using an integrative taxonomic approach.

PMID:36418607 | DOI:10.1007/s10709-022-00175-5

Environ Monit Assess. 2022 Nov 24;195(1):145. doi: 10.1007/s10661-022-10736-y.

ABSTRACT

The current study emphasizes on the applicability of combining the electrokinetic (EK) and permeable reactive barriers (PRB) techniques compared to the simple EK technique. For this purpose, a statistical analysis is conducted using the Fractional Factorial Design statistical method. Also, General Linear Model and Two-sample T-Test analyzes are considered to clarify which type of soil remediation technique represents the highest efficiency. Calcium peroxide, an affordable material with easy capability for cultivation, is utilized in the PRB process to eliminate the soil from diesel contamination. The experiments were performed for 3 days and 10 days, according to which the initial contamination rates of 10 and 20% were selected, and the applied voltages were 20 V and 30 V. Using the innovative remediation technique, the experiments were conducted for 10 days with 20% initial pollution content and the applied voltage of 30 V, the initial gasoil content was about 190.5 mg/g, and after applying the proposed technique, the average final pollution content throughout soil reached approximately 37 mg/g. This experiment was also conducted for the approximately initial gasoil content of 185, 206, and 191 mg/g, which led to the removal efficiency of 79.59%, 78.93%, and 79.15%, respectively. The main novelty of this paper is attributed to the use of calcium peroxide in the EK-PRB technique and the statistical analysis conducted in this study that indicates the remarkable efficiency of the proposed approach. It was also revealed that the efficiency of the proposed technique is on par with the other state-of-art ones presented in the literature and even sometimes outperforms them.

PMID:36418576 | DOI:10.1007/s10661-022-10736-y

Int Urogynecol J. 2022 Nov 23. doi: 10.1007/s00192-022-05409-w. Online ahead of print.

ABSTRACT

INTRODUCTION AND HYPOTHESIS: Urinary incontinence (UI) and overactive bladder (OAB) are common conditions worldwide. These conditions significantly affect the quality of life (QoL) of patients with limited mobility. Total knee arthroplasty (TKA) is one of the most commonly performed orthopedic procedures, resulting in pain relief, as well as improved function and QoL. This study was aimed at evaluating changes in patients’ mobility as a result of TKA surgery and the effect of these changes on their OAB and UI symptoms.

METHODS: A total of 49 female patients with stage IV osteoarthrosis were included in the study. The International Consultation on Incontinence Question-Short Form (ICIQ-SF), Overactive Bladder-Validated 8 (OAB-V8), Visual Analog Scale (VAS), and Oxford Knee Score (OKS) forms were completed pre-operatively and at the 6th post-operative month. Both knee flexion angles were measured, and the post-void residual urine volume (PVR) was recorded.

RESULTS: A statistically significant (p<0.001) decrease was observed in the ICIQ-SF, VAS, OKS, and OAB-V8 scores in the post-operative period compared with the pre-operative values. No statistically significant change was detected in PVR (p=0.103). There was a statistically significant increase in the flexion angle (p<0.001).

CONCLUSIONS: After knee arthroplasty, there was a noticeable improvement in the OAB symptoms and UI complaints of the patients. Therefore, we consider that increasing mobility after TKA will positively affect OAB/UI in female patients.

PMID:36418570 | DOI:10.1007/s00192-022-05409-w

Psychopharmacology (Berl). 2022 Nov 23. doi: 10.1007/s00213-022-06275-6. Online ahead of print.

ABSTRACT

RATIONALE: Unconditioned tasks in rodents have been the mainstay of behavioural assessment for decades, but their validity and sensitivity to detect the behavioural consequences of early life stress (ELS) remains contentious and highly variable.

OBJECTIVES: In the present study, we carried out a meta-analysis to investigate whether persistent behavioural effects, as assessed using unconditioned procedures in rats, are a reliable consequence of early repeated maternal separation, a commonly used procedure in rodents to study ELS.

METHODS: A literature search identified 100 studies involving maternally separated rats and the following unconditioned procedures: the elevated plus maze (EPM); open field test (OFT); sucrose preference test (SPT) and forced swim task (FST). Studies were included for analysis if the separation of offspring from the dam was at least 60 min every day during the pre-weaning period prior to the start of adolescence.

RESULTS: Our findings show that unconditioned tasks are generally poor at consistently demonstrating differences between control and separated groups with pooled effect sizes that were either small or non-existent (EPM: Hedge’s g = – 0.35, p = 0.01, OFT: Hedge’s g = – 0.32, p = 0.05, SPT: Hedge’s g = – 0.33, p = 0.21, FST: Hedge’s g = 0.99, p = 0.0001). Despite considerable procedural variability between studies, heterogeneity statistics were low; indicating the lack of standardization in the maternal separation protocol was the not the cause of these inconsistent effects.

CONCLUSIONS: Our findings indicate that in general, unconditioned tests of depression and anxiety are not sufficient to reveal the full behavioural repertoire of maternal separation stress should not be relied upon in isolation. We argue that more objective tasks that sensitively detect specific cognitive processes are better suited for translational research on stress-related disorders such as depression.

PMID:36418564 | DOI:10.1007/s00213-022-06275-6

Qual Life Res. 2022 Nov 24. doi: 10.1007/s11136-022-03306-9. Online ahead of print.

ABSTRACT

PURPOSE: Memory deficits are very frequent in patients with drug-resistant epilepsy, but they predict a small proportion of variance of their quality of life (QOL) in previous studies, possibly due to the lack of consideration of mediating factors of this relationship. This study aimed to examine whether trait anxiety mediates the relationship between memory and QOL in this population, controlling the influence of demographic and seizure-related factors.

METHODS: In this cross-sectional study, 119 adults with drug-resistant temporal lobe epilepsy (TLE) underwent a neuropsychological evaluation, in which memory, anxiety, and QOL were assessed.

RESULTS: In the total sample, better delayed memory had an effect on better QOL indirectly through lower trait anxiety (B = 0.13, SE = 0.06, p = 0.04, ab_cs = 0.13; κ² = 0.18; PM_ind = 0.76). Additionally, delayed memory has not a direct association with QOL (B = 0.04, SE = 0.09, p = 0.64, Cohen’s f ² = 0.005; PM_dir = 0.24), and the total effect of delayed memory on QOL tended to reach statistical significance (B = 0.17, SE = 0.10, p = 0.08). The proposed mediation model yielded excellent fit (CFI = 1.00, RMSEA = 0.0001, SRMR = 0.009, and χ² (1) = 0.50, p = 0.48) and explained 38% of the variance of QOL.

CONCLUSION: These findings suggest that trait anxiety is an important factor in understanding the relationship between memory and QOL in patients with TLE, considering the influence of demographic and seizure-related variables, and may have relevant implications for decision-making in this population.

PMID:36418526 | DOI:10.1007/s11136-022-03306-9

Am J Speech Lang Pathol. 2022 Nov 23:1-10. doi: 10.1044/2022_AJSLP-22-00078. Online ahead of print.

ABSTRACT

PURPOSE: Humans experience the world through sensations of touch, taste, smell, vision, and audition. Alterations in sensory acuity occur across the adult life span in all types of sensation. The purpose of this study was to describe possible differences in lip and tongue somatosensation (sense of pressure) for healthy older adults using clinically available measurement tools as compared with previously published data using the same protocol.

METHOD: A total of 33 healthy adults (ages 60-93 years; M = 70.5 years; 19 women) completed bilateral assessment of lip and tongue pressure detection and discrimination using two-point discrimination discs and Von Frey hair monofilaments. Participants reported basic health information and completed a pure-tone hearing threshold assessment within the same session.

RESULTS: Descriptive results are presented for individual data points from healthy aging adults. Group data are compared with previously published data from a cohort of healthy young participants. Although there were no statistically significant differences between the two healthy groups, variations in standard deviations in older adults were observed.

CONCLUSIONS: Two-point discrimination and tactile detection and discrimination using Von Frey hair monofilaments can be used to assess labial and lingual pressure detection and discrimination in healthy aging adults. While not reaching statistical significance, on average, older adults demonstrated increased threshold estimates compared with younger adults with increases in standard deviations up to 11.5 times larger than the younger cohort. Subtle differences in somatosensation across the ages may be important for future comparisons with clinical populations across the life span. These assessment techniques can be used with an aging population to complete objective orofacial somatosensory testing.

PMID:36417766 | DOI:10.1044/2022_AJSLP-22-00078

J Speech Lang Hear Res. 2022 Nov 23:1-20. doi: 10.1044/2022_JSLHR-22-00062. Online ahead of print.

ABSTRACT

PURPOSE: Open science is a collection of practices that seek to improve the accessibility, transparency, and replicability of science. Although these practices have garnered interest in related fields, it remains unclear whether open science practices have been adopted in the field of communication sciences and disorders (CSD). This study aimed to survey the knowledge, implementation, and perceived benefits and barriers of open science practices in CSD.

METHOD: An online survey was disseminated to researchers in the United States actively engaged in CSD research. Four-core open science practices were examined: preregistration, self-archiving, gold open access, and open data. Data were analyzed using descriptive statistics and regression models.

RESULTS: Two hundred twenty-two participants met the inclusion criteria. Most participants were doctoral students (38%) or assistant professors (24%) at R1 institutions (58%). Participants reported low knowledge of preregistration and gold open access. There was, however, a high level of desire to learn more for all practices. Implementation of open science practices was also low, most notably for preregistration, gold open access, and open data (< 25%). Predictors of knowledge and participation, as well as perceived barriers to implementation, are discussed.

CONCLUSION: Although participation in open science appears low in the field of CSD, participants expressed a strong desire to learn more in order to engage in these practices in the future. Supplemental Material and Open Science Form: https://doi.org/10.23641/asha.21569040.

PMID:36417765 | DOI:10.1044/2022_JSLHR-22-00062

IEEE Trans Neural Syst Rehabil Eng. 2022 Nov 23;PP. doi: 10.1109/TNSRE.2022.3223992. Online ahead of print.

ABSTRACT

Prosthetic discrete controller relies on finite state machines to switch between a set of predefined task-specific controllers. Therefore the prosthesis can only perform a limited number of discrete locomotion tasks and need hours to tune the parameters for each user. In contrast, the continuous controller treats a gait cycle in a unified way. Thus it is expected to better facilitate normative biomechanics by providing a gait predictive model to contribute a non-switching controller that supports a continuum of tasks. Furthermore, a better method is to train a personalized trajectory prediction model suitable for personal characteristics according to personal walking data. This paper proposes a Gaussian process enhanced Fourier series (GPEFS) method to construct a gait prediction model that represents the human locomotion as a continuous function of phase, speed and slope. Firstly the joint trajectories are transformed into the Fourier coefficient space by least square method. Then the relationship between each Fourier coefficient and task input can be learned by multiple Gaussian process regression (GPRs) model respectively. Compared with directly using GPR to fit the joint trajectory under multi task, our method greatly reduces the computational burden, so as to meet the real-time application scenario. In addition, in Fourier coefficient space, the difference in all tasks between the Fourier coefficient of personal data and the one of statistical data follows the same trend. Therefore, a personalized prediction model is built to predict an individual’s kinematics over a continuous range of slopes and speeds given only one personalized task at level ground and normal speed. The experimental results show that the gait prediction model and the personalized prediction model are feasible and effective.

PMID:36417749 | DOI:10.1109/TNSRE.2022.3223992

Environ Sci Technol. 2022 Nov 23. doi: 10.1021/acs.est.2c07621. Online ahead of print.

ABSTRACT

More attention has been paid to ubiquitous microplastics (MPs). As a major food producer, the situation of MPs in China’s farmland is of even greater concern. Spatial distributions, characteristics, and compositions of MPs in five types of agricultural lands with representative crops were investigated by collecting 477 soil samples from 109 cities in 31 administrative regions of mainland China. To better control MPs in farmland, nearly 400 field questionnaires were obtained, and meteorological conditions, soil properties, and other statistics were collected to quantify potential sources and determine influencing factors. The average abundances of MPs was 2462 ± 3767 items/kg in the agricultural soils, and MP abundance in the greenhouses, farmlands with film mulching, and blank farmlands from four integrated physical geographic regions were determined. The contributions of agricultural films, livestock and poultry manures, irrigation water, and air deposition to MPs in farmlands have been calculated. Influencing factors, such as recovery method, plowing frequency, meteorological conditions, and part of soil properties, were significantly correlated with the abundances of MPs in the agricultural soils (p < 0.05), while mulching age mainly affected MPs in the greenhouses (p < 0.05). This study provides basic scientific data for decision-making and further analysis.

PMID:36417694 | DOI:10.1021/acs.est.2c07621

J Clin Oncol. 2022 Nov 23:JCO2200070. doi: 10.1200/JCO.22.00070. Online ahead of print.

ABSTRACT

PURPOSE: The COVID-19 pandemic-related disruptions in health care delivery might have affected end-of-life care in patients with cancer. We examined changes in place of death and hospice support for Medicaid and commercially insured patients during the pandemic.

PATIENTS AND METHODS: We linked Washington State cancer registry records with claims from Medicaid and two commercial insurers for patients with solid tumor age 18-64 years. The study included 322 Medicaid and 162 commercial patients who died between March 2017 and June 2019 (pre-COVID-19), along with 90 Medicaid and 47 commercial patients who died between March and June 2020 (COVID-19). Place of death was categorized as hospital, hospice (home or nonhospital facility), and home without hospice. Place of death was compared using adjusted multinomial logistic regressions stratified by payer and time period (pre-COVID-19 v COVID-19). The clinical and sociodemographic factors associated with dying at home without hospice were examined, and adjusted marginal effects (ME) are reported.

RESULTS: In the adjusted pre-COVID-19 analysis, Medicaid patients were more likely than commercially insured patients to die in hospital (48% v 36%; adjusted ME, 11%; P = .02). In the pre-COVID-19/COVID-19 analysis, Medicaid patients’ place of death shifted from hospital (48% v 32%; ME, -16%; P < .01) to home without hospice (19.9% v 38.0%; ME, 16.5%; P < .01). However, there were no statistically significant changes pre-COVID-19/COVID-19 for commercial patients. As a result, during COVID-19, Medicaid patients were more likely than commercial patients to die at home without hospice (38% v 22%; ME, 16%; P = .04) as were male versus female patients (ME, 16%; P < .01).

CONCLUSION: The pandemic might have disproportionately worsened the end-of-life experience for Medicaid enrollees with cancer. Attention should be paid to societal and health system factors that decrease access to care for Medicaid patients.

PMID:36417688 | DOI:10.1200/JCO.22.00070