Category: Statistics

Int J Clin Pract. 2021 Jun 15:e14537. doi: 10.1111/ijcp.14537. Online ahead of print.

ABSTRACT

OBJECTIVE: To examine the association between hip and knee osteoarthritis (OA) and falls. Potentially relevant articles that examine the association between hip, knee, radiological, and self-reported OA and falls were retrieved from PubMed, EMBASE, Scopus, and Web of Science up until March of 2020.

METHODS: The pooled risk ratios (RRs) as well as their related 95% confidence intervals (CIs) were calculated. Statistic and subgroup analyses were performed. A total of 21 studies involving 146,965 participants were included.

RESULTS: No association was found between hip OA and falls. The pooled RRs value suggested a higher prevalence of falls in knee OA patients (RR=1.35, 95% CI: 1.20 to 1.51, P<0.00001) and self-reported OA (RR=1.33, 95% CI: 1.23 to 1.45, P<0.00001) than in non-OA subjects. The pooled RR value suggested no difference between prevalence of falls in radiological OA patients compared to non-OA subjects (RR=1.82, 95% CI: 0.89 to 3.73, P=0.10). Both radiological and self-reported knee OA seem to be positively associated with falls, while no obvious association was found between hip OA and falls.

CONCLUSIONS: Therefore, knee OA is a risk factor for falls which should be closely monitored.

PMID:34132007 | DOI:10.1111/ijcp.14537

New Phytol. 2021 Jun 15. doi: 10.1111/nph.17558. Online ahead of print.

ABSTRACT

Global vegetation and land-surface models embody interdisciplinary scientific understanding of the behaviour of plants and ecosystems, and are indispensable to project the impacts of environmental change on vegetation and the interactions between vegetation and climate. However, systematic errors and persistently large differences among carbon and water cycle projections by different models highlight the limitations of current process formulations. In this review, focusing on core plant functions in the terrestrial carbon and water cycles, we show how unifying hypotheses derived from eco-evolutionary optimality (EEO) principles can provide novel, parameter-sparse representations of plant and vegetation processes. We present case studies that demonstrate how EEO generate parsimonious representations of core, leaf-level processes that are individually testable and supported by evidence. EEO approaches to photosynthesis and primary production, dark respiration, and stomatal behaviour are ripe for implementation in global models. EEO approaches to other important traits, including the leaf economics spectrum and applications of EEO at the community level are active research areas. Independently tested modules emerging from EEO studies could profitably be integrated into modelling frameworks that account for the multiple time scales on which plants and plant communities adjust to environmental change.

PMID:34131932 | DOI:10.1111/nph.17558

Spec Care Dentist. 2021 Jun 15. doi: 10.1111/scd.12616. Online ahead of print.

ABSTRACT

AIMS: The present study investigated if recurrent manifestation of oral herpes lesions is associated with other factors and impacts the oral health-related quality of life in para-athletes.

METHODS AND RESULTS: The studied population was composed of a convenience sample of 370 Brazilian para-athletes. All included individuals answered questionnaires and were submitted to an oral examination. A self-reported questionnaire addressed demographic and oral health data, including the recurrent manifestation of oral herpes lesions. The Oral Health Impact Profile was also applied in its reduced version with 14 questions (OHIP-14). The population was categorized according to results from previous competitions into a high-performance level, medium-performance level, and regional-performance level. Chi-square or Fisher’s exact tests, odds ratio calculation, logistic regression analysis, and t-tests were performed (α = 5%). Sixty (16.2%) para-athletes reported recurrent manifestations of oral herpes lesions. Para-athletes with sleep bruxism (p = .007) and awake bruxism (p = .048) had a higher chance of reporting oral herpes lesions. Type of breathing was also associated with oral herpes lesions (p = .031). The OHIP-14 mean distribution among the groups was not statistically significant (p > .05).

CONCLUSION: Bruxism and type of breathing were associated with self-reported oral herpes lesions in Brazilian para-athletes.

PMID:34131935 | DOI:10.1111/scd.12616

J Magn Reson Imaging. 2021 Jun 15. doi: 10.1002/jmri.27768. Online ahead of print.

ABSTRACT

BACKGROUND: While reference values of left atrial (LA) deformation parameters in Western populations have been established, reference data in healthy Asian populations are limited.

PURPOSE: To establish age- and sex-specific reference values for LA strain and strain rate (SR) based on a large sample of healthy Chinese adults using magnetic resonance-feature tracking (MR-FT).

STUDY TYPE: Retrospective.

POPULATION: Four hundred and eight healthy Chinese adults (220 males, aged 43.5 ± 11.5 years; 188 females, aged 45.3 ± 12.8 years).

FIELD STRENGTH/SEQUENCE: 1.5 T/balanced steady-state free precession.

ASSESSMENT: Reservoir strain (ε_s ), conduit strain (ε_e ), booster strain (ε_a ), peak positive SR (SRs), peak early negative SR (SRe), and peak late negative SR (SRa) were obtained by MR-FT.

STATISTICAL TESTS: We used Shapiro-Wilk test, Student’s t-test, Mann-Whitney U-test, linear regression, and coefficient of determination (r² ).

RESULTS: Women demonstrated significantly greater LA strain (ε_s [%]: 44.0 ± 9.9 vs. 38.3 ± 8.7; ε_e [%]: 26.7 ± 8.0 vs. 22.3 ± 6.8; ε_a [%]: 17.3 ± 4.4 vs. 16.0 ± 3.8) and SR (SRs [/second]: 1.8 ± 0.5 vs. 1.6 ± 0.4; SRe [/second]: -2.5 ± 0.9 vs. -2.1 ± 0.7; SRa [/second]: -1.9 ± 0.6 vs. -1.8 ± 0.5) than men. For both sexes, aging was significantly associated with decreased ε_s , SRs, ε_e , and SRe (r² = 0.07, r² = 0.05, r² = 0.19, and r² = 0.24 for men; r² = 0.13, r² = 0.11, r² = 0.31, and r² = 0.46 for women), and significantly increased ε_a (r² = 0.03 and r² = 0.05 for men and women). There was no significant correlation between age and SRa in both sexes (P = 0.057 and P = 0.377 for men and women, respectively).

DATA CONCLUSION: We provide age- and sex-specific reference values for LA strain and SR based on a large sample of healthy Chinese adults using MR-FT.

LEVEL OF EVIDENCE: 3 TECHNICAL EFFICACY STAGE: 5.

PMID:34131972 | DOI:10.1002/jmri.27768

Psychon Bull Rev. 2021 Jun 15. doi: 10.3758/s13423-021-01958-1. Online ahead of print.

ABSTRACT

Attention is an important resource for prioritizing information in working memory (WM), and it can be deployed both strategically and automatically. Most research investigating the relationship between WM and attention has focused on strategic efforts to deploy attentional resources toward remembering relevant information. However, such voluntary attentional control represents a mere subset of the attentional processes that select information to be encoded and maintained in WM (Theeuwes, Journal of Cognition, 1[1]: 29, 1-15, 2018). Here, we discuss three ways in which information becomes prioritized automatically in WM-physical salience, statistical learning, and reward learning. This review integrates findings from perception and working memory studies to propose a more sophisticated understanding of the relationship between attention and working memory.

PMID:34131892 | DOI:10.3758/s13423-021-01958-1

J Small Anim Pract. 2021 Jun 16. doi: 10.1111/jsap.13387. Online ahead of print.

ABSTRACT

OBJECTIVE: To determine the median survival time (MST) of dogs with nasal carcinoma treated with toceranib phosphate.

MATERIAL AND METHODS: The databases of four Spanish referral hospitals were retrospectively searched for dogs with a diagnosis of nasal tumours presented between January 2015 and October 2020. Dogs treated with radiotherapy or other chemotherapies prior toceranib were excluded.

RESULTS: Twenty-three dogs with a confirmed nasal carcinoma treated with toceranib phosphate and with a CT scan for initial staging according to Adams Modified Staging System were included. Nine dogs had a stage III nasal carcinoma whereas 14 dogs had a stage IV nasal carcinoma. No dog had stages I and II nasal carcinoma. The median overall survival time was 139 days. The difference between the MST between dogs with stages III and IV was not statistically significant [P = 0.6, 140 days for stage III (range 46-401) vs 120 days for stage IV (range 23-600)]. Overall, dogs with epistaxis achieved a longer median survival (166 days) than dogs without epistaxis (83 days). Toceranib phosphate was generally well tolerated. Most dogs had an initial clinical benefit followed by progressive disease.

SIGNIFICANCE: This is the first study to report the MST in dogs with stages III and IV nasal carcinoma treated with toceranib phosphate. This retrospective study showed that toceranib phosphate decreases the clinical signs associated with nasal carcinomas.

PMID:34131916 | DOI:10.1111/jsap.13387

Mol Biol Rep. 2021 Jun 15. doi: 10.1007/s11033-021-06461-3. Online ahead of print.

ABSTRACT

Fatty acid binding protein 5 (FABP5) is elevated in psoriatic keratinocytes and could be involved in systemic metabolic disturbances in psoriasis. The aim of the study was to evaluate serum FABP5 in obese and non-obese psoriatic patients, to assess the relationship between FABP5 and the duration, severity of the disease, inflammatory and metabolic markers and influence of treatment with narrowband-ultraviolet B (NB-UVB). Seventy-four patients (30 treated with NB-UVB) with psoriasis were enrolled in the study. The serum concentrations of FABP5 were measured using Human FABP5 Enzyme-Linked Immunosorbent Assay kit. Serum fatty acids were measured by gas-liquid chromatography. Serum FABP5 levels in psoriatic patients were higher versus control group (P < 0.001). FABP5 in patients with PASI > 20 was higher compared to the mild group (PASI < 10) (P < 0.001) and serum FABP5 correlated positively with PASI score (r = 0.41, P < 0.001). There was also positive correlation between FABP5 and basic inflammation indices. Decrease of PASI after NB-UVB treatment (P < 0.001) was observed and accompanied by decrease of the serum FABP5 (P = 0.007). FABP5 is a potential marker of psoriasis, its severity and clinical outcome after therapy with NB-UVB. FABP5 may reflect metabolic disturbances in psoriatic patients.

PMID:34131888 | DOI:10.1007/s11033-021-06461-3

Psychon Bull Rev. 2021 Jun 15. doi: 10.3758/s13423-021-01923-y. Online ahead of print.

ABSTRACT

Experimental psychologists often neglect the poor psychometric properties of the dependent measures collected in their studies. In particular, a low reliability of measures can have dramatic consequences for the interpretation of key findings in some of the most popular experimental paradigms, especially when strong inferences are drawn from the absence of statistically significant correlations. In research on unconscious cognition, for instance, it is commonly argued that the lack of a correlation between task performance and measures of awareness or explicit recollection of the target stimuli provides strong support for the conclusion that the cognitive processes underlying performance must be unconscious. Using contextual cuing of visual search as a case study, we show that given the low reliability of the dependent measures collected in these studies, it is usually impossible to draw any firm conclusion about the unconscious character of this effect from correlational analyses. Furthermore, both a psychometric meta-analysis of the available evidence and a cognitive-modeling approach suggest that, in fact, we should expect to see very low correlations between performance and awareness at the empirical level, even if both constructs are perfectly related at the latent level. Convincing evidence for the unconscious character of contextual cuing and other effects will most likely demand richer and larger data sets, coupled with more powerful analytic approaches.

PMID:34131891 | DOI:10.3758/s13423-021-01923-y

Environ Geochem Health. 2021 Jun 15. doi: 10.1007/s10653-021-01007-9. Online ahead of print.

ABSTRACT

Present study was carried out to explore heavy metals pollution and potential ecological risk factors associated with agriculture soil irrigated with industrial effluents of Hayatabad industrial estate, Peshawar (HIEP) and Gadoon industrial estate, Sawabi (GIES) of Khyber-Pakhtunkhwa, Pakistan through multivariate geo-statistical tools. Diverse statistical tools like cluster analysis (HC) and principal component analysis (PCA), along with geo-statistical approaches were applied to highlight the geogenic and anthropogenic sources of pollution. The results indicated that concentration of heavy metals in target areas was significantly higher than control. Both soils had significant to moderate enrichment of heavy metals, while Gadoon soil had moderate to considerable ecological risk factor. The geo accumulation indices (Igeo) tendency for heavy metals in both target soil (Gadoon and Hayatabad) were the same. The Pb concentration of both target areas falls in the extremely severely polluted category because of the excessive presence of industries producing lead-containing products. Hence, this study indicated that the majority of toxic heavy metals contributed to soil pollution in the studied areas are coming from industrial and commercial activities.

PMID:34131852 | DOI:10.1007/s10653-021-01007-9

J Robot Surg. 2021 Jun 15. doi: 10.1007/s11701-021-01262-z. Online ahead of print.

ABSTRACT

To evaluate potential factors associated with the risk of perioperative blood transfusion (PBT) with implications on length of hospital stay (LOHS) and major post-operative complications in patients who underwent robot-assisted radical prostatectomy (RARP) as a primary treatment for prostate cancer (PCa). In a period ranging from January 2013 to August 2019, 980 consecutive patients who underwent RARP were retrospectively evaluated. Clinical factors such as intraoperative blood loss were evaluated. The association of factors with the risk of PBT was investigated by statistical methods. Overall, PBT was necessary in 39 patients (4%) in whom four were intraoperatively. Positive surgical margins, operating time and intraoperative blood loss were associated with perioperative blood transfusion on univariate analysis. On multivariate analysis, the risk of PBT was predicted by intraoperative blood loss (odds ratio, OR 1.002; 95% CI 1.001-1.002; p < 0.0001), which was associated with prolonged operating time and elevated body mass index (BMI). PBT was associated with delayed LOHS and Clavien-Dindo complications > 2. In patients undergoing RARP as a primary treatment for PCa, the risk of PBT represented a rare event that was predicted by severe intraoperative bleeding, which was associated with increased BMI as well as with prolonged operating time. In patients who received a PBT, prolonged LOHS as well as an elevated risk of major Clavien-Dindo complications were seen.

PMID:34131882 | DOI:10.1007/s11701-021-01262-z