Nevin Manimala

Phys Rev Lett. 2026 Jun 5;136(22):221801. doi: 10.1103/c1x7-f9wn.

ABSTRACT

The first measurements of the top- and antitop-quark differential production cross sections and the top-quark charge asymmetry in the forward region are presented, using proton-proton collision data collected by the LHCb experiment at a center-of-mass energy of 13 TeV corresponding to an integrated luminosity of 5.4 fb^{-1}. The total production cross sections of top and antitop quarks are also determined. Measurements are performed using the μ+b-jet final state within a fiducial region defined by b-jet p_{T,jet}>50 GeV and pseudorapidity 2.2<η_{jet}<4.0, with the muon from the W-boson decay required to have p_{T,μ}>25 GeV and 2.0<η_{μ}<4.5. The muon and b-jet system must satisfy p_{T}(μ+jet)>20 GeV. The measured integrated production cross sections for the top and antitop quarks are σ_{t}=0.95±0.04±0.08±0.02 pb, σ_{t[over ¯]}=0.81±0.03±0.07±0.02 pb, where the first uncertainty is statistical, the second systematic, and the third accounts for the luminosity uncertainty. The top-quark charge asymmetry is measured to be A_{C}^{t}=0.08±0.03±0.01, where the first uncertainty is statistical and the second is systematic. These results are consistent with next-to-leading order Standard Model predictions.

PMID:42330470 | DOI:10.1103/c1x7-f9wn

Sex Transm Dis. 2026 Jun 23. doi: 10.1097/OLQ.0000000000002381. Online ahead of print.

ABSTRACT

BACKGROUND: Testing for sexually transmitted infections (STIs) is a routine component of prenatal care. Treating partners is challenging and the inconsistency contributes to maternal reinfection and neonatal morbidity. This study evaluated documentation of partner treatment among pregnant women diagnosed with different STIs.

METHODS: This retrospective cohort study included pregnant women who received care at two safety-net hospitals in Harris County, TX, between 2019 and 2022. Electronic health records were reviewed for documented partner treatment among patients with chlamydia, gonorrhea, hepatitis B infection (HBV), or syphilis during pregnancy. Patients with chlamydia and gonorrhea are typically offered expedited partner therapy by physicians, whereas the local health department coordinates partner treatment of HBV and syphilis. Gaps in hospital and health department records were supplemented through brief patient interviews. Multivariable Poisson regression models with robust error variance examined associations between STI and physician counseling on partner treatment, adjusting for age, race and ethnicity, marital status, preferred language, and substance use. Adjusted relative risk (aRR) with 95% confidence intervals (CI) were calculated. P<0.05 was considered statistically significant.

RESULTS: Among 369 eligible patients, physician documentation of partner treatment was highest for patients with chlamydia only (54%), followed by gonorrhea only (46%), syphilis (43%), and lowest for HBV (1%). Documented barriers to partner treatment included lack of partner contact (gonorrhea only 75%, chlamydia only 43%, syphilis 34%) and partner refusal (HBV 43%). Physician counseling on partner treatment was documented for ≥80% of patients with STIs except HBV (56%, aRR=0.68 compared to chlamydia only, 95% CI 0.51-0.91). Sufficient prenatal care was associated with higher partner treatment for chlamydia only (67% vs. 45%, p=0.023).

CONCLUSIONS: Partner treatment and physician counseling vary by STI. Physician reliance on public health-managed partner treatment may hinder completion and sustain high rates of STIs during pregnancy.

PMID:42330427 | DOI:10.1097/OLQ.0000000000002381

PLoS One. 2026 Jun 22;21(6):e0351890. doi: 10.1371/journal.pone.0351890. eCollection 2026.

NO ABSTRACT

PMID:42330424 | DOI:10.1371/journal.pone.0351890

Rheumatology (Oxford). 2026 Jun 22:keag321. doi: 10.1093/rheumatology/keag321. Online ahead of print.

ABSTRACT

OBJECTIVES: Lymphoid interstitial pneumonia (LIP) is a rare form of Interstitial Lung Disease (ILD), often associated with Sjögren Disease (SjD). However, the clinical-serologic characteristics of SjD-LIP remain poorly characterized. Our objective was to describe the clinical course and outcome of SjD-associated LIP and to compare this subgroup with other SjD-ILD patterns.

METHODS: SjD patients with HRCT-confirmed ILD followed in Pisa Rheumatology Unit (January 2019-November 2024) were retrospectively enrolled. ILD patterns were classified through multidisciplinary discussion. Clinical and laboratory data were collected according to ESSDAI definitions, along with pulmonary symptoms and function tests (PFTs).

RESULTS: Fifty-five SjD-ILD patients were included (M: F = 9:46), of whom 11 were diagnosed with LIP (F: M = 11:0). LIP patients showed thin-walled parenchymal cysts as the predominant HRCT finding, and largely preserved pulmonary function (median FVC 101% [IQR 98-105]; DLCO 76% [IQR 75-81]). After a median 5-years follow-up (IQR 2-7) all LIP patients were alive with stable PFTs. Compared with the remaining 44 non-LIP, LIP patients were younger at SjD diagnosis (p<0.001) and more frequently presented purpura (p=0.012), constitutional symptoms (p=0.001), lymphadenopathy (p=0.023), hypergammaglobulinemia (p<0.001), triple anti-Ro60/52/La positivity (p=0.035) and C3 hypocomplementemia (p=0.009).ILD preceded SjD diagnosis in 30/44 non-LIP vs 1/11 LIP patients (p<0.001), with lower FVC% (p=0.049) and DLCO% (p=0.036) in non-LIP.

CONCLUSION: LIP defines a distinct, immunologically active phenotype within the spectrum of SjD-ILD, characterized by greater extrapulmonary systemic involvement and serologic markers of B cell hyperactivity, but limited pulmonary functional impact. These findings support long-term lymphoma surveillance and a potential role for B cell targeted therapies in selected patients.

PMID:42330423 | DOI:10.1093/rheumatology/keag321

Medicina (B Aires). 2026;86(3):575-584.

ABSTRACT

INTRODUCTION: Massive bone defects remain a significant challenge in limb reconstruction and salvage procedures. The aim of this study was to analyze the clinical outcomes and implant survival in a series of patients undergoing extensive femoral resections reconstructed with modular megaprosthesis.

MATERIALS AND METHODS: A retrospective case analysis was conducted including patients who underwent massive femoral bone resections, with a median age of 59 years (IQR 57-70) and a mean follow-up of 6.7 years (SD 4.9). Twenty-nine endoprostheses were used for oncologic resections and eleven for non-oncologic massive bone defects. Reconstructions included 21 proximal femurs, 17 distal femurs, one intercalary prosthesis, and one total femur replacement. Implant survival, complication rates and their management were analyzed. Functional outcomes were assessed using the Musculoskeletal Tumor Society (MSTS) scoring system.

RESULTS: Nineteen patients (47.5%) experienced complications: 9 in proximal femoral reconstructions and 7 in distal femoral cases. The most frequent complication was periprosthetic joint infection 20% (8), followed by prosthetic dislocation 15% (6), and aseptic loosening 10% (4). The MSTS improved from (11.8 ± 6.2) preoperatively to (17.3 ± 7.9) (p< 0.001). The incidence of death was higher in patients with an oncologic diagnosis compared to non-oncologic diagnosis. without reaching statistical significance.

CONCLUSION: Modular resection endoprostheses offer a versatile option for segmental bone reconstruction, providing acceptable mid-term functional outcomes. However, prosthetic instability, particularly in proximal femoral replacements and periprosthetic joint infection remains a frequent relevant complication.

PMID:42330373

Bioinformatics. 2026 Jun 22:btag432. doi: 10.1093/bioinformatics/btag432. Online ahead of print.

ABSTRACT

SUMMARY: We developed DirectASRM, a comprehensive database for the systematic identification, integration, and annotation of allele-specific RNA modifications (ASRMs) from direct RNA sequencing data. DirectASRM enables single-base, transcript-level detection of ASRMs across multiple RNA modification types, diverse organisms and condition-specific contexts. The database further evaluates the confidence of each ASRM-SNP pair association within isoform context by jointly considering statistical evidence of allelic modification imbalance and independent support from external next-generation sequencing (NGS) – based RNA modification resources. DirectASRM also provides extensive functional annotations for ASRMs and their associated variants, including intra-sample transcript-level allele-specific expression (ASE) and allele-specific splicing, as well as additional post-transcriptional regulatory features such as miRNA binding, circRNA, RNA-protein interactions, and disease relevance. Overall, DirectASRM serves as a comprehensive resource that supports systematic investigation of the potential functional impact of genetic variants in epitranscriptomic regulation.

AVAILABILITY AND IMPLEMENTATION: DirectASRM database is freely accessible at http://modinfor.com/DirectASRM/. DirectASRM pipeline is available at GitHub (https://github.com/jiayin1101/DirectASRM_pipeline) and Zenodo (DOI: https://doi.org/10.5281/zenodo.19876077).

SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

PMID:42330361 | DOI:10.1093/bioinformatics/btag432

Adv Sci (Weinh). 2026 Jun 22:e76249. doi: 10.1002/advs.76249. Online ahead of print.

ABSTRACT

Phenolic photodissociation at the air-water interface proceeds orders of magnitude faster than in bulk water, yet the structural origins of this acceleration remain insufficiently understood. Here, we present a descriptor-level analysis supporting a dual-control picture, in which phase-dependent photodissociation reflects both πσ*-related dark-state accessibility and the local solvent’s capacity to accommodate transferred electron density. We construct a structure-resolved, statistics-driven framework that bypasses snapshot-level multireference conical-intersection searches by identifying solvent-side dark-state acceptor orbitals {σ_p*}, constructing their energy distribution ε(σ_p*), and linking it to local microenvironment descriptors that quantify coordination saturation and directional constraint. Truncated cluster models prove unreliable because boundary microstates dominate acceptor selection and mask the intrinsic interface-bulk contrast. Periodic slab models remove this bias: the interfacial ε(σ_p*) distribution is shifted lower by approximately 0.7 eV and substantially broadened relative to bulk, predominantly through within-motif energy-window shifts rather than differences in hydrogen-bond topology. Low-coordination, weakly constrained microenvironments correlate systematically with lower ε(σ_p*), and small-system SA-CASSCF diagnostics support the same trend direction. Together, these descriptor-level signatures indicate that the air-water interface favors both dark-state access and transferred-electron stabilization, providing transferable inputs for multiphase photochemical modeling and strategies for tuning interfacial reactivity through control of defect-rich microstate supply.

PMID:42330358 | DOI:10.1002/advs.76249

Br J Radiol. 2026 Jun 22:tqag153. doi: 10.1093/bjr/tqag153. Online ahead of print.

ABSTRACT

OBJECTIVES: To compare the diagnostic performance of Dual-Energy CT (DECT), Diffusion-Weighted MRI (DWI), and Chemical Shift MRI (CSI) in differentiating metastatic from non-metastatic cervical lymph nodes in patients with head and neck cancer, using histopathology as the reference standard.

METHODS: In this prospective cross-sectional study, 38 patients with suspected head and neck malignancy underwent DECT, DWI, and CSI prior to histopathological evaluation. A total of 194 lymph nodes were analysed. Quantitative parameters including DWI- apparent diffusion coefficient (ADC), DECT- normalised iodine concentration (NIC), spectral HU, electron density, effective atomic number and CSI in-out phase ratio were assessed. Diagnostic performance was evaluated using receiver operating characteristic (ROC) analysis, and comparison between modalities was performed using the DeLong test.

RESULTS: Of 194 lymph nodes, 71 were metastatic and 122 were non-metastatic. ADC values were significantly lower in metastatic nodes (p < 0.0001). Dual-energy CT parameters and chemical shift MRI did not show statistically significant differences. ROC analysis demonstrated superior diagnostic performance of ADC compared to other parameters.

CONCLUSION: DWI demonstrates superior diagnostic performance in differentiating metastatic cervical lymph nodes, while DECT and CSI show limited utility. Multiparametric MRI, particularly DWI, should be preferred for nodal characterization in head and neck cancer.

ADVANCES IN KNOWLEDGE: This study provides direct comparative evidence showing that ADC-based DWI is significantly superior to DECT quantitative parameters and CSI for nodal metastasis detection, supporting its role as the primary functional imaging tool.

PMID:42330356 | DOI:10.1093/bjr/tqag153

Rev Esc Enferm USP. 2026 Jun 22;60:e20250573. doi: 10.1590/1980-220X-REEUSP-2025-0573en. eCollection 2026.

ABSTRACT

OBJECTIVE: To assess the knowledge, attitudes, and practices of self-medication and factors associated with this behavior among students in the health field.

METHOD: A cross-sectional study conducted at a public university in Minas Gerais with 237 students. Data collection was carried out using a structured form to obtain sociodemographic variables and information on knowledge, attitudes, and practices regarding self-medication. Descriptive analysis and regression modeling were performed.

RESULTS: The majority (84.8%) reported practicing self-medication and demonstrated a high level of favorability for the behavior; 57.7% demonstrated adequate knowledge. Students in the early grades were more likely to have inadequate knowledge. Favorable attitudes were significantly associated with the 18-20 age group and low income. The highest rates of self-medication were statistically linked to young people and those who self-identified as Black.

CONCLUSION: The high incidence of self-medication and the false perception of technical autonomy highlight the medicalization of life as a response to academic pressures. The results demonstrated vulnerabilities associated with structural inequalities and reinforce the need for institutional interventions focused on medication safety.

PMID:42330354 | DOI:10.1590/1980-220X-REEUSP-2025-0573en

Eur Stroke J. 2026 Jun 2;11(6):aakag066. doi: 10.1093/esj/aakag066.

ABSTRACT

INTRODUCTION: Adverse non-motor outcomes dominate the lived reality of post-stroke recovery, yet remain poorly understood after intravenous thrombolysis (IVT), endovascular thrombectomy (EVT) or both. We characterised the prevalence of outcomes in 13 non-motor domains, stratified by mRS scores, and identified baseline factors associated with adverse outcomes at 6 months follow-up.

METHODS: We conducted a prospective observational sub-study within the Stroke Investigation Group in North and Central London (SIGNAL) registry to characterise non-motor outcomes after IVT, EVT or both. At 6 months, we assessed mRS alongside 13 patient-reported non-motor domains, including neuropsychiatric, fatigue, sleep, social participation, sensory, autonomic and cognitive outcomes. We used unadjusted analysis to estimate prevalence and adjusted multivariate logistic regression to investigate associated baseline factors.

RESULTS: We included 642/646 (99.3%) eligible surviving patients (median age 73 years; 43.5% female; median NIHSS = 5; mRS = 1) treated with IVT, EVT or both. At 6 months, the prevalence of adverse non-motor outcomes across 13 domains ranged from 18% to 56% across all treatment groups. Among patients with a favourable functional outcome (mRS 0-2, n = 409), fatigue (51.3%), sleep disturbance (47.6%) and mood problems (39.6%) were most prevalent. In those with an unfavourable outcome (mRS 3-5, n = 233), dependency in activities of daily living (51.0%), reduced social participation (44.3%) and bladder dysfunction (41.0%) were common. Stroke recurrence, female sex and baseline NIHSS > 5 were significantly associated with multiple adverse non-motor outcomes at 6 months.

CONCLUSION: Despite favourable mRS, a high proportion of patients treated with IVT and/or EVT report adverse non-motor outcomes. Systematic non-motor assessments alongside mRS are needed to accurately capture post-stroke symptom burden and guide person-centred life after stroke care.

PMID:42330319 | DOI:10.1093/esj/aakag066