Nevin Manimala

Violence Against Women. 2022 Feb 21:10778012221079372. doi: 10.1177/10778012221079372. Online ahead of print.

ABSTRACT

Self-reported survey data on the extent and nature of rape and sexual assault experienced by a population represent an important source of information because these crimes often go unreported, and are thus undercounted in law enforcement or other official statistics. This article compares Campus Climate Survey Validation Study (CCSVS) data to Clery Act data in an effort to (1) assess the validity of the CCSVS data and the Clery Act data based on the extent to which they corroborate one another, and (2) estimate the extent to which Clery Act data potentially underestimate the true incidence of rape. The results help to establish the extent to which self-report surveys on sexual victimization are needed to understand the magnitude of the problem among a given population.

PMID:35188846 | DOI:10.1177/10778012221079372

Comput Methods Biomech Biomed Engin. 2022 Feb 21:1-14. doi: 10.1080/10255842.2022.2039640. Online ahead of print.

ABSTRACT

This study is relevant to present the numerical form of the nonlinear dengue fever SIR system are presented using the artificial neural networks along with the Levenberg-Marquardt backpropagation technique, i.e. ANNs-LMB. The procedures of ANNs-LMB are applied with three different sample data scales based on testing, training and authentication. The statistics to solve three cases of the nonlinear dengue fever based on susceptible, infected and recovered system are selected with 75%, 15% and 10% for training, validation and testing, respectively. To find the numerical results of the nonlinear dengue fever system, the reference dataset is designed on the basis of Adams scheme for the numerical solution. The numerical results based on the nonlinear dengue fever system are obtained through the ANNs-LMB to reduce the mean square error. In order to check the exactness, reliability, effectiveness and competence of the proposed ANNs-LMB, the numerical outcomes are proficient to the proportional measures using the topographies of the fitness attained in mean squared error sense, correlation, error histograms and regression.

PMID:35188837 | DOI:10.1080/10255842.2022.2039640

J Telemed Telecare. 2022 Feb 21:1357633X221077869. doi: 10.1177/1357633X221077869. Online ahead of print.

ABSTRACT

INTRODUCTION: Pharmacy students should be eHealth literate by being skilful in searching, evaluating and applying online health information. Mobile health applications should be utilised when making clinical decisions to achieve optimal patient care with the ever-changing pharmacy practice. This study aims to explore the eHealth literacy and mobile health application utilisation amongst pharmacy undergraduates.

METHODS: A cross-sectional study was conducted from March to April 2021. An online survey, consisting of socio-demographic characteristics, Internet use, eHealth Literacy Scale and mobile health application utilisation, was distributed amongst pharmacy undergraduates in public and private universities in Malaysia. Data analysis included descriptive statistics, one-way analysis of variance test, Mann-Whitney U test and Kruskal-Wallis test.

RESULTS: A total of 415 participants completed the survey (response rate = 82.5%). The median eHealth Literacy Scale score (out of 40) was 31.0 ± 3.0 (interquartile range). More than one-third of participants (34.7%) were found to have low eHealth literacy. Many lacked confidence in making health decisions from online information (42.4%) and skills in distinguishing between high-quality and low-quality health resources (35.2%). Only 70.4% of the participants had mobile health applications installed on their smartphones and/or tablets. Some students felt that they were neither knowledgeable nor skilful enough to utilise mobile health applications (24.8%), whereas 23.9% were unaware of the mobile health applications available.

CONCLUSION: In summary, the eHealth literacy of Malaysian pharmacy students can be further enhanced by incorporating eHealth literacy-focused programmes into the curriculum. Moreover, pharmacy students’ mobile health application utilisation can be improved through increased awareness and support from universities.

PMID:35188826 | DOI:10.1177/1357633X221077869

J Clin Oncol. 2022 Feb 21:JCO2102085. doi: 10.1200/JCO.21.02085. Online ahead of print.

ABSTRACT

PURPOSE: The survival impact of secondary cytoreductive surgery in patients with platinum-sensitive recurrent ovarian cancer was studied.

METHODS: We identified published studies from 1983 to 2021 following our inclusion criteria from MEDLINE, EMBASE, and Cochrane library. To integrate the effect size of single-arm studies, meta-analysis was performed using death rate as a primary outcome. The effect of complete cytoreduction and optimal cytoreduction on survival was evaluated using meta-regression. The pooled death rate was presented with a 95% CI. The publication bias was evaluated with the funnel plot and Egger’s test, and sensitivity analysis was performed. To overcome missing death rates, the linear regression model was performed on log-transformed median overall survival (OS) time using study size as a weight.

RESULTS: Thirty-six studies with 2,805 patients reporting death rates were used for this meta-analysis of the 80 eligible studies. There was strong heterogeneity, with the P value of the Cochrane Q test of < 0.0001 and Higgins’s I² statistics of 86%; thus, we considered a random effect model. The pooled death rate was 44.2% (95% CI, 39.0 to 49.5), and both the complete and optimal cytoreductions were associated with better survival outcomes as significant moderators in the meta-regression model (P < .001 and P = .005, respectively). Although 14 studies were located outside the funnel plot, Egger’s test indicated no publication bias (P = .327). A sensitivity analysis excluding 14 studies showed similar results. In the linear regression model on the basis of 57 studies, the median OS time increased by 8.97% and 7.04% when the complete and optimal cytoreduction proportion increased by 10%, respectively, after adjusting other variables.

CONCLUSION: Secondary cytoreductive surgery, resulting in maximal tumor resection, significantly prolongs OS in platinum-sensitive recurrent ovarian cancer.

PMID:35188810 | DOI:10.1200/JCO.21.02085

ACS Nano. 2022 Feb 21. doi: 10.1021/acsnano.1c08488. Online ahead of print.

ABSTRACT

Aligning large populations of colloidal nanorods (NRs) into ordered assemblies provides a strategy for engineering macroscopic functional materials with strong optical anisotropy. The bulk optical properties of such systems depend not only on the individual NR building blocks but also on their meso- and macroscale ordering, in addition to more complex interparticle coupling effects. Here, we investigate the dynamic alignment of colloidal CdSe/CdS NRs in the presence of AC electric fields by measuring concurrent changes in optical transmission. Our work identifies two distinct scales of interaction that give rise to the field-driven optical response: (1) the spontaneous mesoscale self-assembly of colloidal NRs into structures with increased optical anisotropy and (2) the macroscopic ordering of NR assemblies along the direction of the applied AC field. By modeling the alignment of NR ensembles using directional statistics, we experimentally quantify the maximum degree of order in terms of the average deviation angle relative to the field axis. Results show a consistent improvement in alignment as a function of NR concentration─with a minimum average deviation of 36.2°─indicating that mesoscale assembly helps facilitate field-driven alignment of colloidal NRs.

PMID:35188744 | DOI:10.1021/acsnano.1c08488

Ann Clin Transl Neurol. 2022 Feb 21. doi: 10.1002/acn3.51515. Online ahead of print.

ABSTRACT

OBJECTIVE: The aim was to study the evolution of disability in spinocerebellar ataxias (SCAs) type 1, 2, 3, and 6 (SCA1, 2, 3, 6).

METHODS: We analyzed data of two longitudinal cohorts (RISCA, EUROSCA) which recruited ataxic and non-ataxic SCA1, SCA2, SCA3, and SCA6 mutation carriers. To study disability, we used a five-stage system for ataxia defined by walking ability (stages 0-3) and death (stage 4). Transitions were analyzed using a multi-state model with proportional transition hazards. Based on the hazard estimates, transition probabilities and the expected lengths of stay in each stage were calculated. We further studied the effect of sex and CAG repeat length on progression.

RESULTS: Data of 3138 visits in 677 participants were analyzed. Median SARA scores for SCA1, SCA2, SCA3, and SCA6 ranged from 1.5 (interquartile range [IQR] = 0.0-3.5) to 3.5 (IQR = 1.4-6.1) in stage 0, 11.5 (IQR = 9.6-14.0) to 13.8 (IQR = 11.0-16.0) in stage 1, 19.0 (IQR = 17.0-21.0) to 23.8 (IQR = 19.5-27.0) in stage 2, and 28.5 (IQR = 26.0-32.5) to 34.0 (IQR = 32.6-37.1) in stage 3. Modeling allowed to calculate the subtype-specific probability to be in a certain stage at a given age and duration of each stage. CAG repeat length was associated with faster progression in SCA1 (HR, 95% CI: 1.1, 1.1-1.2), SCA2 (1.2, 1.1-1.3), and SCA3 (1.1, 1.0-1.2). In SCA6, female sex was associated with faster progression (1.7, 1.1-2.6).

INTERPRETATION: Our data are important for counselling of patients, assessment of the relevance of outcome markers, and design of clinical trials.

PMID:35188716 | DOI:10.1002/acn3.51515

J Magn Reson Imaging. 2022 Feb 21. doi: 10.1002/jmri.28122. Online ahead of print.

ABSTRACT

BACKGROUND: Nonenhanced MR angiography (MRA) studies are often used to manage acute and chronic large cervical artery disease, but lengthy scan times limit their clinical usefulness.

PURPOSE: To develop an accelerated cervical MRA and test its diagnostic performance.

STUDY TYPE: Prospective.

POPULATION: Patients with cervical artery disease (n = 32, 17 males).

FIELD STRENGTH/SEQUENCE: 3.0 T; accelerated two-point Dixon three-dimensional Cartesian spoiled gradient-echo (FLEXA) and conventional time-of-flight MRA (cMRA) sequences.

ASSESSMENT: All patients underwent FLEXA (1’28″) and cMRA (6’47″) acquisitions. Quantitative evaluation (artery-to-background signal ratio and a blur metric) and qualitative evaluation using diagnostic performance measured by the sensitivity, specificity, and positive/negative predictive values (PPV/NPV), and vessel and plaque visualization scores from three board-certified radiologists’ (with 10, 11, and 12 years of experience) independent readings using maximum intensity projection (MIP) for luminal diseases and axial images for plaque. The reference standards were contrast-enhanced angiography and fat-saturated T1-weighted images, respectively.

STATISTICAL TESTS: All measures were compared between FLEXA and cMRA using the paired t, Wilcoxon signed-rank, McNemar’s, or chi-squared test, as appropriate. Interreader agreement was assessed using Cohen’s κ. P < 0.05 was considered statistically significant.

RESULTS: The artery-to-background signal ratio was significantly higher for FLEXA (FLEXA: 7.20 ± 1.63 [fat]; 4.26 ± 0.52 [muscle]; cMRA: 2.57 ± 0.49 [fat]), while image blurring was significantly less (FLEXA: 0.24 ± 0.016; cMRA: 0.30 ± 0.029). In luminal disease detection, sensitivity (FLEXA: 0.97/0.91/0.91; cMRA:0.71/0.69/0.63), specificity (FLEXA: 0.98/0.93/0.98; cMRA:0.93/0.85/0.92), PPV (FLEXA: 0.92/0.86/0.86; cMRA: 0.64/0.5/0.58), and NPV (FLEXA: 0.99/0.98/0.98; cMRA: 0.92/0.91/0.9) were significantly higher for FLEXA. interreader agreement was substantial to almost perfect for FLEXA (κ = 0.82/0.86/0.78) and moderate to substantial for cMRA (κ = 0.67/0.56/0.57). MIP visualization scores were significantly higher for FLEXA, with substantial to almost perfect interreader agreement (FLEXA: κ = 0.83/0.86/0.82; cMRA: κ = 0.89/0.79/0.79). In plaque detection, sensitivity (FLEXA: 0.9/0.9/0.7; cMRA: 0.3/0.6/0.2) and specificity (FLEXA: 1/0.87/1; cMRA: 0.93/0.63/0.97) were significantly higher for FLEXA in two of three readers. The interreader plaque detection agreement was fair to substantial (FLEXA: κ = 0.63/0.69/0.48; cMRA: κ = 0.21/0.45/0.20). Side-by-side plaque and vessel wall visualization was superior for FLEXA in all readers, with moderate to substantial interreader agreement (plaque: κ = 0.73/0.73/0.77; vessel wall: κ = 0.57/0.40/0.39).

DATA CONCLUSION: FLEXA enhanced visualization of the cervical arterial system and improved diagnostic performance for luminal abnormalities and plaques in patients with cervical artery diseases.

LEVEL OF EVIDENCE: 1 TECHNICAL EFFICACY STAGE: 2.

PMID:35188699 | DOI:10.1002/jmri.28122

J Magn Reson Imaging. 2022 Feb 21. doi: 10.1002/jmri.28081. Online ahead of print.

ABSTRACT

BACKGROUND: Diastolic dysfunction (DD) frequently occurs in dialysis patients; however, the risk factors of DD remain to be further explored in such a population. Epicardial adipose tissue (EAT) volume has proven to be an independent clinical risk factor for multiple cardiac disorders.

PURPOSE: To assess whether EAT volume is an independent risk factor for DD in dialysis patients.

STUDY TYPE: Case-control study.

POPULATION: A total of 113 patients (mean age: 54.5 ± 14.4 years; 41 women) who had underwent dialysis for at least 3 months due to uremia.

FIELD STRENGTH: A 3 T, steady-state free precession (SSFP) sequence for cine imaging, modified Look-Locker imaging (MOLLI) for T1 mapping and gradient-recalled-echo for T2*.

ASSESSMENT: All participants were performed cardiac magnetic resonance imaging (MRI) and echocardiogram. For MRI images analysis, borders of the EAT were manually delineated, as well as, pericardial adipose tissue (PeAT) and paracardial adipose tissue (PaAT), T1 mapping, T2* mapping, global longitudinal strain (GLS), and left atrial strain. For echocardiogram assessments, the thickness of PaAT, e’ velocity, E velocity, E/e ratio, A velocity, and deceleration time were measured.

STATISTICAL TESTS: Univariate and multivariate logistic regressions were performed to explore the independent risk factors for DD. P value less than 0.05 was considered as significant.

RESULTS: Compared with the DD(-) group, the DD(+) group had significantly more epicardial tissue fat (18.5 ± 1.3 vs. 30.9 ± 2.3) In addition, EAT volumes increased significantly with the grades of DD (grade 1 vs. grade 2 and 3: 27.9 ± 15.9 vs. 35.4 ± 13.1). Moreover, EAT had significant correlations with T1 mapping, T2* mapping, GLS, left atrial strain, e’ velocity, and E/e ratio. EAT accumulation added an independent risk for DD (Odds Ratio = 1.03) over conventional clinical risk factors including age, diabetes mellitus, and hemodialysis.

DATA CONCLUSION: EAT was associated with diastolic function, and its accumulation may be an independent risk factor for DD among dialysis patients.

EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2.

PMID:35188692 | DOI:10.1002/jmri.28081

Stat Med. 2022 Feb 21. doi: 10.1002/sim.9291. Online ahead of print.

NO ABSTRACT

PMID:35188678 | DOI:10.1002/sim.9291

Acta Psychiatr Scand. 2022 Feb 21. doi: 10.1111/acps.13417. Online ahead of print.

ABSTRACT

BACKGROUND: We report the psychometric properties of the Patient-Reported Impact of Symptoms in Schizophrenia Scale (PRISS), which assesses the impact of subjective experiences or qualia in outpatients with this condition.

METHODS: A cross-sectional study was carried out in 162 patients diagnosed with schizophrenia in Spain. The PRISS measures the presence, frequency, concern and interference with daily life of self-reported experiences related to the main symptoms observed in these patients. The psychometric analysis included test-retest reliability, internal consistency and structural and convergent validity.

RESULTS: The 28-item PRISS showed good test-retest reliability as 64.3% of the intraclass correlation coefficient values were between 0.40 and 0.79, which were statistically significant (p<0.01). Analysis of the structural validity revealed a three-factor structure, 1) productive subjective experiences, 2) affective-negative subjective experiences and 3) excitation, which accounted for 56.11% of the variance. Of the Pearson’s correlation coefficients analysed between the PRISS and the Positive and Negative Syndrome Scale (PANSS), Scale for Assessment of Negative Symptoms (SANS) and World Health Organization Disability Assessment Schedule (WHO-DAS), 72.2% were statistically significant (p<0.05) and ranged from: 0.38-0.42, 0.32-0.42 and 0.40-0.42 respectively.

CONCLUSION: Our results indicate that the PRISS appears to be a brief, reliable and valid scale to measure subjective experiences in schizophrenia and provides valuable information complementary to clinical evaluation.

PMID:35188673 | DOI:10.1111/acps.13417