Tag: nevin manimala

Int J Paleopathol. 2025 Dec 1;52:32-43. doi: 10.1016/j.ijpp.2025.11.004. Online ahead of print.

ABSTRACT

OBJECTIVE: This paper demonstrates computational modeling’s value as a tool for mapping the impact of hidden variables and evaluating the accuracy of statistical methods in bioarchaeology.

MATERIALS: As a working example, this paper presents an agent-based model of a 1,000-person cohort of individuals who can form an unspecified skeletal lesion at any age between birth and ten years and enter a simulated cemetery at the end of their lives. Skeletal lesions either have no effect on mortality risk (scenario 1) or are associated with doubled mortality risk (scenario 2).

METHODS: The agent-based model simulates data on individual age at death and lesion status. Kaplan-Meier survival analysis is run on each simulated dataset, comparing survival estimates for individuals with and without lesions.

RESULTS: Survival analyses underestimate the true value of lesion-associated mortality risk in early life in scenario 2 and produce a false lesion-associated survival advantage under the null conditions of scenario 1.

CONCLUSIONS: Researchers should account for the ages of a skeletal lesion’s developmental window, where known, when assessing lesion-associated mortality. Survival analyses return accurate results when they exclude individuals in the ages of active lesion formation.

SIGNIFICANCE: Modeling experiments can identify which archaeologically unmeasurable variables have the greatest impact on estimates of population health and outline the ways in which they bias estimates of past health from the skeletal record.

LIMITATIONS: The only limits on modeling are limits of imagination and common sense.

SUGGESTIONS FOR FUTURE RESEARCH: Many other archaeologically hidden variables remain to be explored with this approach.

PMID:41330016 | DOI:10.1016/j.ijpp.2025.11.004

Cortex. 2025 Nov 15;194:35-49. doi: 10.1016/j.cortex.2025.11.003. Online ahead of print.

ABSTRACT

Children’s ability to extract statistical regularities from speech is considered fundamental to lexical, syntactic, and grammatical development. However, the neural oscillatory mechanisms supporting this process in childhood remains poorly understood. While beta-band oscillations have been linked to statistical learning in visual and motor domains, it is unclear whether similar dynamics support auditory statistical learning in children. In this study, we recorded electroencephalography (EEG) from children aged 8-12 years as they listened to a continuous stream of trisyllabic nonwords (e.g., dapiku), where syllable order within each nonword was fixed (high predictability), but transitions between nonwords were variable (low predictability). Beta power was significantly lower for the more predictable second and third syllables relative to the less predictable first syllable. This effect emerged only after repeated exposure and was localised to left prefrontal electrodes. Beta power also correlated with post-exposure recognition accuracy. Additional learning-related modulations were observed in the theta-alpha and delta-theta bands, suggesting broader oscillatory engagement. These findings indicate that auditory statistical learning in middle childhood engages frequency-specific neural dynamics, with beta power modulations showing parallel effects to those observed in other modalities.

PMID:41330012 | DOI:10.1016/j.cortex.2025.11.003

Transl Oncol. 2025 Dec 1;63:102620. doi: 10.1016/j.tranon.2025.102620. Online ahead of print.

ABSTRACT

BACKGROUND: Gastric cancer (GC) remains a major cause of cancer-related mortality globally, largely due to the absence of reliable non-invasive biomarkers for early detection. Circular RNAs (circRNAs), characterized by covalently closed-loop structures, stability, and detectability in circulation, have emerged as promising liquid biopsy candidates.

METHODS: circAHSA1 (hsa_circ_0032777) was identified through GEO dataset screening (GSE121445) and validated in GC tissues, serum, and cell lines using qRT-PCR with optimized internal reference selection. Diagnostic performance was assessed using ROC analysis and DeLong tests, evaluating circAHSA1 alone and in combination with CEA, CA199, and CA724. Biological functions were examined through proliferation, apoptosis, migration, and invasion assays. Subcellular localization and potential downstream miRNA interactions were analyzed using nuclear-cytoplasmic fractionation and multi-database bioinformatic prediction.

RESULTS: circAHSA1 expression was significantly elevated in GC tissues, serum, and cell lines, and correlated with lymph node metastasis, differentiation status, and TNM stage. Serum circAHSA1 effectively discriminated GC from healthy controls (AUC = 0.787) and gastritis patients (AUC = 0.752), outperforming conventional markers, with statistical superiority confirmed by DeLong analysis. Combined detection further improved diagnostic accuracy (AUC = 0.871). Functionally, silencing circAHSA1 suppressed GC cell proliferation, migration, and invasion while enhancing apoptosis and inducing cell-cycle arrest. Bioinformatic analysis suggested miR-647 and miR-661 as potential downstream targets.

CONCLUSIONS: circAHSA1 is a stable, GC-specific circulating biomarker with both diagnostic and functional relevance. These findings support circAHSA1 as a promising candidate for liquid biopsy-based GC detection and a potential therapeutic target.

PMID:41330006 | DOI:10.1016/j.tranon.2025.102620

J Community Psychol. 2026 Jan;54(1):e70067. doi: 10.1002/jcop.70067.

ABSTRACT

This study assessed (1) the prevalence of witnessing violence and personal victimization, (2) links between community violence exposure (CVE) and depressive and PTSD symptoms, and (3) family cohesion as a moderator in these associations among rural Mexican adults. Data were drawn from a larger mixed methods study with 200 Mexican adults (ages of 20-60; M_age = 40.7; 79.5% women) from the State of Mexico. Preliminary analyses indicated that participants reported more experiences of witnessing violence than personal victimization. Hierarchical regression analyses revealed that only witnessing violence was significantly associated with depressive and PTSD symptoms. Family cohesion did not moderate these associations. Qualitative content analysis was conducted to further explore and contextualize a subset of participants’ experiences with community violence. Findings underscore the high prevalence of CVE among rural Mexican adults and its significant associations with mental health. This study expands the predominantly urban-focused CVE literature and highlights the need for culturally and contextually informed prevention and intervention efforts.

PMID:41329992 | DOI:10.1002/jcop.70067

NCHS Data Brief. 2025 Jun;(532):1. doi: 10.15620/cdc/174601.

ABSTRACT

INTRODUCTION: Adults age 65 and older have higher death rates from unintentional falls than other age groups, and falls are the leading cause of injury-related death in this population.

METHODS: National Vital Statistics System underlying cause-of-death mortality data for 2003-2023 were used in this study of unintentional fall deaths in adults age 65 and older, by sex, age group, and race and Hispanic origin. Unintentional fall deaths were identified using International Classification of Diseases, 10th Revision underlying cause-of-death codes W00-W19. Crude rates (deaths per 100,000 population) were calculated. Pairwise comparisons were conducted using the z test ( p < 0.05), and trends were assessed using the Joinpoint Regression Program (Version 5.0.2).

KEY FINDINGS: The U.S. rate of unintentional fall deaths for adults age 65 and older was 69.9 per 100,000 population in 2023, with rates varying by state. In 2023, the unintentional fall death rate for adults age 65 and older was higher for men (74.2) compared with women (66.3). Rates for both men and women increased with increasing age. Among adults age 85 and older, White non-Hispanic adults had the highest rate of unintentional fall deaths, and Black non-Hispanic adults had the lowest rate. For both men and women, rates of unintentional fall deaths increased between 2003 and 2023 for adults ages 65-74, 75-84, and 85 and older.

PMID:41329986 | DOI:10.15620/cdc/174601

Folia Med Cracov. 2025 Jul 31;65(2):142-152. doi: 10.24425/fmc.2025.156131.

ABSTRACT

There is a lack of research that methodically clarifies baseline muscle tone values and demonstrates their activation during balance tests using selected parts of the 4-Stage Balance Test. The study involved 41 men and 34 women (mean age approximately 22 years (X = 21.83 y, SD 1.5 y)). Data were collected using a questionnaire containing socio-demographic and anthropometric data. Range of motion was measured using a goniometer (SFTR Goniometer Baseline 360 degrees), limb length and circumference were measured using a ADE MZ10021 tape measure and static balance was assessed using two tests from the 4-Stage Balance Test. Eight muscles (Rectus Femoris (RF), Vastus Lateralis (VL), Vastus Medialis (VM), Semitendinosus (S), Biceps Femoris (BF), Tibialis Anterior (TA), Gastrocnemius Medialis (GM), Gastrocnemius Lateralis (GL)) bioelectrical activity data were obtained using a Noraxon MR 400 sEMG device and MyoTrace software. Statistical analysis was performed using SPSS Statistics v25. In parallel foot position the highest EMG activity was observed in the VM (99.18 mV), S (55.27 mV) and RF (33.06 mV) muscles. In semi-tandem foot position the highest activity was observed in S (120.8 mV), GM (59.03 mV), and TA (47.84 mV) muscles, with the lowest in BF (6.58 mV) muscle. 1. Lowered base of support increases the activity of the semitendinosus and medial gastrocnemius muscles. 2. Maintaining the feet-together stance depends on the synergy between the semitendinosus and medial gastrocnemius muscles. 3. Maintaining semi-tandem positioned halfway in front of the other foot depends on the synergy between the vastus lateralis and tibialis anterior muscles.

PMID:41329980 | DOI:10.24425/fmc.2025.156131

Folia Med Cracov. 2025 Jul 31;65(2):101-111. doi: 10.24425/fmc.2025.156128.

ABSTRACT

OBJECTIVES: The study examined the natural progression of squamous intraepithelial lesions (SIL) and human papilloma virus (HPV) infection during pregnancy, comparing initial and postpartum results. It also assessed delivery mode’s impact on outcomes and strategies to improve follow-up care for women with abnormal cervical cancer screening results.

METHODS: This retrospective study analyzed data from 59 pregnant women with SIL/positive HPV, assessing variables such as cytology, HPV status, and delivery mode. Statistical tests included Wilcoxon rank-sum and Fisher’s exact tests.

RESULTS: The average age of patients was 29 years. Over 50% were primigravidas. A significant reduction in abnormal cytology was observed postpartum (89.83% vs. 62.50%, p = 0.009), with an increase in normal results (10.17% vs. 37.50%). No significant differences were found in HPV status (88.89% vs. 81.25%, p =0.655). Colposcopy findings were stable for 76.32% of patients between Visits 1 and 2, with 50% stability between Visits 2 and 3. Postpartum, 30.43% showed regression, while 8.70% showed progression (p = 0.017, padj < 0.050). Higher regression rates were observed after vaginal birth compared to the cesarean section (45.45% vs. 15.38%, p = 0.182) but no significant differences were found (p = 1.000). Almost 60% of patients were lost to postpartum follow-up.

CONCLUSION: Further studies with a larger population of Polish patients are needed. Cervical cancer screening should be optimized and integrated into a national registry. Pregnant patients with abnormal screening results should be managed by experts, and strategies to enhance patient compliance must be implemented.

PMID:41329977 | DOI:10.24425/fmc.2025.156128

Folia Med Cracov. 2025 Jul 31;65(2):93-99. doi: 10.24425/fmc.2025.156127.

ABSTRACT

The gold standard for assessing liver fibrosis is core needle biopsy. Its invasive nature, however, limits its wide use. Hence the need for non-invasive methods in patients with hepar venostaticum due to right ventricular [RV] failure: one of them is the FIB4 index. Another method, Fibroscan, is based on an ultrasound technique from elastography.

OBJECTIVE: to assess the correlation and determination indices between the FIB4 index and the assessment of liver stiffness by Fibroscan (E) on one hand and echocardiographic parameters describing RV function on the other hand. The study group: 33 patients (74 ± 13 years) with heart failure due to pulmonary hypertension, arterial hypertension, valvular diseases, myocardial infarction or cardiomyopathy.

RESULTS: echocardiography – RV dimension 38 ± 8 mm, systolic pressure in pulmonary artery (SPAP) 53 ± 24 mmHg, tricuspid annular plane systolic excursion (TAPSE) 17 ± 4mm, acceleration time of flow through the pulmonary valve (ACT) 79 ± 23 ms, the degree of tricuspid valve regurgitation 2 ± 1; the FIB4 result in this group – 2.54 ± 1.19, and the stiffness index E: 13.79 ± 12.55 kPa. Only RV dimension and the degree of tricuspid valve regurgitation showed moderately strong positive correlation with the stiffness index E: the correlation index – 0.327 and 0.382, respectively, with the determination index 27.9% and 43.4%, respectively.

CONCLUSION: The results emphasize the relationship between the morphological remodeling of the RV and the degree of secondary tricuspid regurgitation and the advancement of fibrotic changes in the liver and encourage the continuation of studies on larger groups of patients with a homogeneous etiology of RV failure, using a wider spectrum of echocardiographic parameters.

PMID:41329976 | DOI:10.24425/fmc.2025.156127

Eur Heart J Acute Cardiovasc Care. 2025 Dec 2:zuaf158. doi: 10.1093/ehjacc/zuaf158. Online ahead of print.

ABSTRACT

BACKGROUND: Contemporary guidelines support the use of a pharmaco-invasive (PI) strategy with immediate transfer to a percutaneous coronary intervention (PCI)-capable hospital for ST-elevation myocardial infarction (STEMI) when timely primary PCI (pPCI) is unattainable. However, when reperfusion with fibrinolysis fails to occur, rescue PCI is recommended.

METHODS: In a pre-specified analysis from STREAM-2, we explored patients randomized to PI treatment and compared those receiving half-dose tenecteplase who required rescue intervention to those with successful fibrinolysis undergoing scheduled angiography. To provide context for those randomized pPCI, we also explored the relationship between site of randomization, i.e., community hospital (CH) versus ambulance on clinical outcomes. Resolution of ST-elevation following angiography and the composite of 30-day all-cause death, shock, heart failure and reinfarction, as well as safety, reflected by stroke and non-intracranial bleeding, were measured.

RESULTS: Of the 583 patients in the current study, 168 patients required rescue intervention [43.5%], 218 patients had successful fibrinolysis scheduled for angiography and 197 were randomized to pPCI. Rescue PCI patients, compared to those undergoing scheduled angiography, had less ST resolution ≥50% (76.3% versus 92.5%, P<0.001) and worse clinical composite outcomes at 30 days (16.7% versus 6.0%, P<0.001) with a higher risk of intracranial hemorrhage (2.4% versus 0.5%). Intermediate outcomes were observed for patients undergoing pPCI (ST resolution ≥50%: 78.7%; 30-day composite outcome: 12.2%). Rescue intervention deployed in CH patients required 10 minutes longer compared to ambulance patients: however, there was similar ST resolution ≥50% (72.2% versus 80.5%, P=0.219) and comparable 30-day composite outcome (17.6% versus 15.7%, relative risk [RR] 0.97, 95% confidence interval [CI] 0.50 – 1.87), irrespective of location. pPCI required 48 minutes longer in CH patients, but resulted in similar outcomes to ambulance patients (ST resolution ≥50%: 77.0% versus 80.2%, P=0.595; 30-day composite outcome: 9.3% versus 15.6%, RR 1.57, 95% CI 0.72-3.41, respectively).

CONCLUSION: Contemporary PI with half-dose tenecteplase in older patients requiring rescue intervention led to less ST resolution and worse 30-day outcomes compared to those with successful fibrinolysis receiving scheduled angiography. Notably, delays to deploying rescue PCI in CH patients were shortened over those previously achieved thereby resulting in similar outcomes to those randomized in the ambulance. Our results reinforce the benefits of functional hub and spoke models with rapid transfer to a PCI-capable facility.

PMID:41329963 | DOI:10.1093/ehjacc/zuaf158

JMIR Res Protoc. 2025 Dec 2;14:e71680. doi: 10.2196/71680.

ABSTRACT

BACKGROUND: Suboptimal diet quality and physical inactivity are key risk factors for chronic disease and disability in Canada. However, the lack of high-quality population-level data hinders the development of evidence-based strategies to support improvements in diet quality, movement behaviors (physical inactivity, activity, and sleep), and health. The lack of data is also a barrier to developing capacity in diet and physical activity assessment and epidemiology in Canada.

OBJECTIVE: This protocol describes the development of the largest known repository of dietary intake and movement behavior data in Canada by drawing upon an existing longitudinal cohort study, the Canadian Partnership for Tomorrow’s Health (CanPath). In the short-term, the data will be used to examine associations between system factors (eg, retail food environments) and dietary intake. In the longer-term, data will be available to pursue a range of research questions, including longitudinal associations between diet, movement behavior, and health outcomes.

METHODS: Participants in CanPath (>330,000 adults) who can complete online questionnaires are eligible and will be asked to complete a baseline web-based questionnaire including questions on demographic characteristics and screeners capturing dietary intake and movement behaviors. Subsequently, participants will be invited to complete an online 24-hour dietary recall using the Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24-Canada-2018) and an online 24-hour activity recall using Activities Completed Over Time in 24 Hours (ACT24). Repeat recalls will be administered 1-2 weeks later. A subset of participants will be invited to complete 2 additional ASA24-Canada-2018 and Activities Completed Over Time in 24 Hours recalls 6 months later. One year after baseline, participants will be invited to complete past-year diet and movement behavior questionnaires. In Québec, dietary intake and movement behavior data are from 3000 CanPath participants enrolled in the NutriQuébec study. Participant addresses will be linked to geospatial data on the food, built, and social environment.

RESULTS: Data collection began in 2025. As of manuscript acceptance (November 4, 2025), 3171 participants had been recruited. Data processing and cleaning will be completed in 2027, and analyses will occur in 2028. It is anticipated that dietary intake and movement behavior data will be available for up to 100,000 adults.

CONCLUSIONS: This protocol outlines the collection of detailed data on dietary intake and movement behavior in a large cohort spanning all provinces in Canada. In addition to allowing examination of a range of research questions related to diet, movement behavior, and health, the combination of assessment tools will support methodological research, including expanding analytical strategies to mitigate the effects of error in dietary and movement behavior data. This effort will also build capacity in the collection, processing, and harmonization of dietary and movement behavior data among cohorts and provide a training ground for emerging researchers.

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/71680.

PMID:41329954 | DOI:10.2196/71680