Tag: nevin manimala

Euro Surveill. 2026 Apr;31(13). doi: 10.2807/1560-7917.ES.2026.31.13.2500586.

ABSTRACT

BACKGROUNDMany countries use school-based vaccination for adolescent vaccination; it has been shown to reduce inequities in uptake compared with other delivery routes. In England, coverage for human papillomavirus (HPV), meningococcal groups A, C, W and Y (MenACWY) and tetanus, diphtheria and inactivated polio virus (Td/IPV) vaccine programmes exceeded 80% before the COVID-19 pandemic. However, recent data show declining uptake.AIMThis study examined the relationship between socio-economic deprivation and coverage over time.METHODSWe conducted an ecological analysis of first-dose coverage for HPV (females and males), MenACWY and TdIPV in adolescents across 150 local authorities in England from 2017 to 2024. Coverage data were linked to 2025 Index of Multiple Deprivation (IMD) scores. Associations between IMD quintile, academic year and vaccination coverage were estimated using beta regression models.RESULTSBetween 2020 and 2024, lower coverage was consistently associated with higher deprivation, and differences in coverage between the most and least deprived IMD quintiles more than doubled. In 2024 these differences were 17.7%, 18.2%, 16∙8% and 16.9% for HPV (females), HPV (males), MenACWY and Td/IPV, respectively. The consistency of these findings suggests the effect of deprivation on coverage is not vaccine-specific.CONCLUSIONWe demonstrated a consistent and strengthening association between coverage and deprivation across multiple adolescent school-based vaccination programmes in England over time. Contributory factors may be numerous, and further research is needed to understand which factors are driving trends for different populations. Addressing these inequalities will require sustained targeted interventions to improve awareness of and access to vaccination.

PMID:42141866 | DOI:10.2807/1560-7917.ES.2026.31.13.2500586

Euro Surveill. 2026 Mar;31(12). doi: 10.2807/1560-7917.ES.2026.31.12.2500628.

ABSTRACT

BACKGROUNDVaccination of residents and healthcare workers (HCWs) against influenza in nursing homes is an important prevention strategy.AIMTo describe trends in influenza vaccination coverage (VC) among HCWs working in nursing homes in France and measures implemented to support vaccination campaigns from 2007 to 2025, and to identify effectiveness of these measures.METHODSWe analysed data from seven nationwide cross-sectional studies conducted between seasons 2007/08 and 2024/25 and performed multivariate analysis using negative binomial regressions, to identify determinants.RESULTSNational influenza VC among HCWs decreased from 37.2% (95% CI: 35.7-39.4) in 2007/08 to 24.2% (95% CI: 23.2-25.1) in 2024/25 (mean: 39,740 HCWs per season, 6 seasons). Vaccination coverage disparities by category of HCWs (2024/25 VC of physicians: 56.3%; nurses: 34.2%; nursing assistants: 19.3%) were observed throughout the period. Measures to promote influenza vaccination were less frequently implemented over time: support of vaccination campaigns by the management team (from 2018/19: 89% to 2024/25: 52%), implementation of collective (68% to 49%) or individual information sessions (19% to 9%), distribution of information on influenza vaccines (64% to 53%) or influenza (83% to 69%). Seven measures exhibited effectiveness in 2018/19 compared to only four in 2024/25, which had less effectiveness. Management teams highlighted the strong reluctance of HCWs to receive influenza vaccination.CONCLUSIONSInfluenza VC among HCWs in nursing homes is marked by disparities among professional categories. To mitigate the decline in VC among HCWs, it is essential to implement effective measures to support the campaigns.

PMID:42141864 | DOI:10.2807/1560-7917.ES.2026.31.12.2500628

Euro Surveill. 2026 Mar;31(12). doi: 10.2807/1560-7917.ES.2026.31.12.2600235.

ABSTRACT

Following the first detection of monkeypox virus (MPXV) clade Ib in Berlin, Germany, in December 2025, clade Ib rapidly predominated over clade IIb among notified mpox cases. The 35 clade Ib cases were primarily due to autochthonous transmission, with high genetic relatedness among strains circulating in men in Berlin, despite no identified epidemiological links. Sexual contact between men was reported as a potential source of infection in 28 cases, while for the remaining seven cases this information was unknown.

PMID:42141863 | DOI:10.2807/1560-7917.ES.2026.31.12.2600235

Euro Surveill. 2026 Apr;31(17). doi: 10.2807/1560-7917.ES.2026.31.17.2500733.

ABSTRACT

BACKGROUNDTick-borne encephalitis (TBE), a neuroinvasive disease in humans, is endemic in north-east Italy and nationally notifiable since 2017. Domestic TBE incidence, although low, has increased in recent years while TBE vaccination coverage remains < 10%.AIMWe aimed to estimate the burden of TBE virus (TBEV) infections in north-east Italy (Triveneto) in 2017-2024.METHODSWe estimated disability-adjusted life years (DALYs) with 95% uncertainty intervals (UI) using the Burden of Communicable Diseases in Europe software. Input data included TBE cases notified in 2017-2024 with residence and/or infection or exposure in Triveneto (autonomous provinces (AP) of Trento and Bolzano and regions of Veneto and Friuli-Venezia Giulia) and correction factors for TBE underdiagnosis and TBEV infection under-ascertainment.RESULTSIn 2017-2024, 295 TBE cases were notified in Triveneto. The mean annual burden of TBEV infections was estimated at 0.58 (95% UI: 0.55-0.62) DALYs per 100,000 population. Estimates were highest in 2022 (1.07; 95% UI: 1.00-1.14 DALYs/100,000). The areas with the highest burden were Belluno province (4.17; 95% UI: 3.88-4.46 DALYs/100,000/year) and the AP of Trento (2.84; 95% UI: 2.65-3.05 DALYs/100,000/year). Males accounted for 67.0% of DALYs. All age groups experienced on average ≤ 1 DALYs per 100,000 population per year.CONCLUSIONThe burden of TBEV infections in north-east Italy is relatively low and with an uneven geographical distribution. Increasing TBE vaccination coverage across age groups, prioritising elevated impact areas, may reduce the burden of TBEV infections in north-east Italy and maintain TBE as a low-burden disease.

PMID:42141861 | DOI:10.2807/1560-7917.ES.2026.31.17.2500733

Workplace Health Saf. 2026 May 16:21650799261440222. doi: 10.1177/21650799261440222. Online ahead of print.

ABSTRACT

BACKGROUND: The COVID-19 pandemic revealed stressful working conditions experienced by health care workers in long-term care and seniors’ (LTCS) homes worldwide. However, differences in job strain among regulated and unregulated health care workers and its relationship to their health are understudied. This study examined associations between job strain-related working conditions and health changes, exploring differences between nurses and personal support workers (PSWs).

METHODS: This cross-sectional study used the Survey of Health Care Workers’ Experiences During the Pandemic (2021). Job strain-related working conditions included workload increases, working overtime, and beyond-role work. Outcomes were workers’ perceived changes in general health and mental health during the pandemic. Descriptive statistics and multivariable logistic regression models were employed, stratified by occupation, and controlled for covariates.

FINDINGS: Job strain prevalence during the pandemic was high, with more nurses reporting job strain-related working conditions (increased workloads, overtime, or beyond-role work) than PSWs. Associations between job strain working conditions and worsened health varied by occupation. Beyond-role work was associated with worsened mental health for both workers, but only worsened general health for nurses, not PSWs.

CONCLUSIONS: Differences among nurses and PSWs demonstrate the importance of understanding variations in roles, occupational experiences and policies regulating health care workers.

APPLICATION TO PRACTICE: These findings support the need for targeted monitoring of mental and general health among nurses and PSWs in LTCS settings. Occupational health practitioners can identify experiences of job strain among staff and provide counsel for solutions, collaborating with management to ensure the LTCS workforce’s health and safety.

PMID:42141859 | DOI:10.1177/21650799261440222

Anat Sci Educ. 2026 May 16. doi: 10.1002/ase.70257. Online ahead of print.

ABSTRACT

In medical and anatomy education, serious games (SGs) are increasingly recognized as promising pedagogical tools. Educators seeking to adopt SG may choose whether to build games or buy commercially available serious games (CASGs). However, exploration of the commercial market remains scarce as existing reviews focus on bibliographic databases. This study aimed to explore the commercial market for SG aimed at medical education and analyze the pedagogical underpinnings of SG for anatomy education. An environmental scan was conducted across five search areas targeting digital interactive games intended for healthcare professionals. Out of 4330 potential games identified, 1585 CASG for medical education were included after screening and eligibility assessment. Subsequently, 879 CASG for anatomy education were systematically evaluated against 15 pedagogical principles adapted from instructional and game design frameworks. Data extraction, scoring, and statistical analysis explored the presence of pedagogical principles and influencing factors. Findings show that the commercial market offers a range of CASG for medical education, primarily targeting knowledge acquisition in human anatomy for undergraduates. Most SG were quiz-based, designed for single player, and lacked affiliation with academic institutions. Systematic analysis of CASG for anatomy education shows few incorporations of pedagogical principles with in-game feedback and game rules being most common, while principles supporting engagement, adaptivity, and collaboration were scarce. In conclusion, while the commercial market offers SG for anatomy education, their educational potential remains constrained by limited pedagogical depth, which may limit their potential as pedagogical tools. These findings suggest opportunities to develop pedagogically robust games in anatomy education.

PMID:42141858 | DOI:10.1002/ase.70257

Health Promot Pract. 2026 May 16:15248399261445966. doi: 10.1177/15248399261445966. Online ahead of print.

ABSTRACT

This mixed-methods study explored the impact of community-based arts programming on psychosocial outcomes associated with trauma recovery among adults with low-to-no-income engaged in active recovery from homelessness, domestic abuse, substance use, and other forms of trauma. Conducted in partnership with Path with Art, the study assessed mental well-being, social connectedness, and self-efficacy using validated pre- and post-intervention surveys alongside qualitative exit-surveys. Participants (N = 80) demonstrated statistically significant improvements in mental well-being (p < .01), loneliness (p < .01), and self-efficacy (p = .02), following participation in 8-week community-based arts classes. Analysis of qualitative responses (N = 103) revealed five interconnected themes: social connection and community; mental and emotional well-being; personal growth and empowerment; motivation and purpose; and creative and educational engagement. Participants reported feeling less isolated, more confident and motivated, and described the arts as a meaningful tool for navigating challenges related to trauma recovery. The findings suggest community-based arts engagement supports psychosocial processes central to trauma recovery. While limitations such as self-selection bias and lack of a control group should be addressed in future research, the study contributes to growing evidence that arts programming can positively influence health outcomes in trauma-affected populations. These insights may inform public health strategies and community-based care models focused on recovery and resilience.

PMID:42141855 | DOI:10.1177/15248399261445966

Helicobacter. 2026 May-Jun;31(3):e70132. doi: 10.1111/hel.70132.

ABSTRACT

BACKGROUND: Vonoprazan-based dual therapy has been proposed as a simplified strategy for Helicobacter pylori eradication, but head-to-head comparisons of different antibiotic partners are limited. We compared the efficacy, safety, and adherence of vonoprazan-based dual regimens with those of bismuth-containing quadruple therapy (BQT).

METHODS: In this randomized controlled trial, H. pylori-infected patients were allocated (1:1:1:1) to receive VA (vonoprazan [20 mg, bid] plus amoxicillin [1000 mg, tid]), VT (vonoprazan [20 mg, bid] plus tetracycline [500 mg, tid]), VM (vonoprazan [20 mg, bid] plus minocycline [100 mg, bid]), or VACB (vonoprazan [20 mg, bid], amoxicillin [1000 mg, bid], clarithromycin [500 mg, bid], and bismuth [220 mg, bid]) for 14 days. The primary endpoint was the H. pylori eradication rate, and the secondary endpoints were the incidence of adverse events and patient adherence.

RESULTS: The ITT eradication rates were 83.0% (83/100), 74.0% (74/100), 82.0% (82/100), and 83.0% (83/100) in the VA, VT, VM, and VACB groups, respectively (p = 0.304). The PP eradication rates were 90.2% (83/92), 83.1% (74/89), 88.2% (82/93), and 92.2% (83/90), respectively (p = 0.262). Adverse events occurred in 21.5% of the patients overall and differed across groups (10.0%, 15.0%, 29.0%, and 32.0% in VA, VT, VM, and VACB, respectively; p < 0.001); nausea and dizziness were more frequent with VM, whereas bitter taste and black stool were more frequent with VACB. All adverse events were mild or moderate, and no severe events were recorded. Adherence was high and comparable across groups (VA 100.0%, VT 96.0%, VM 99.0%, VACB 99.0%; p = 0.107).

CONCLUSION: Vonoprazan-based regimens showed no statistically significant between-group differences in eradication and were associated with good adherence overall. In our setting, VA and VM may represent practical simplified options, whereas VT appeared less robust as an empiric regimen. These exploratory findings warrant confirmation in larger, adequately powered randomized trials.

TRIAL REGISTRATION: ClinicalTrials.gov (NCT07068607).

PMID:42141850 | DOI:10.1111/hel.70132

Eur J Neurol. 2026 May;33(5):e70616. doi: 10.1111/ene.70616.

ABSTRACT

BACKGROUND: Elevated blood pressure (BP) after spontaneous intracerebral hemorrhage (ICH) is associated with poor outcomes, but the prognostic value of prehospital BP, particularly in relation to onset-to-arrival time, remains unclear. We investigated time-dependent associations of prehospital BP, arrival BP, and their early difference with in-hospital outcomes.

METHODS: We conducted a retrospective cohort study using a prospectively maintained stroke registry at a tertiary medical center in Taipei, Taiwan (2016-2022). Adults (≥ 18 years) with spontaneous ICH transported by emergency medical services within 24 h of symptom onset and with available prehospital BP were included. First prehospital and hospital-arrival BP were analyzed. Outcomes were in-hospital mortality and stroke in evolution (SIE) within 72 h of hospital admission. Patients were stratified by onset-to-arrival time (< 3 vs. ≥ 3 h). Multivariable logistic regression and restricted cubic splines were applied.

RESULTS: Six hundred ninety patients were included (mean age 64.7 years, 63.1% male; 336 < 3 h, 354 ≥ 3 h). In patients arriving ≥ 3 h, higher prehospital systolic BP, mean arterial pressure, and pulse pressure were independently associated with increased odds of in-hospital mortality, and higher arrival pulse pressure was also associated with mortality. Associations with SIE and early BP differences were weaker and were attenuated in fully adjusted models. Restricted cubic spline showed no nonlinear associations. No significant associations between BP measures and outcomes were observed in patients arriving < 3 h.

CONCLUSIONS: Higher prehospital BP was associated with increased in-hospital mortality among patients presenting ≥ 3 h after onset, whereas such associations are not evident within 3 h.

PMID:42141839 | DOI:10.1111/ene.70616

Acta Paediatr. 2026 May 16. doi: 10.1111/apa.70593. Online ahead of print.

ABSTRACT

AIM: Varicella is a highly contagious disease affecting approximately 90% of children before the age of 10, constituting a substantial health and societal burden. This study investigates the association between socio-demographic and socio-economic factors and uptake of varicella vaccination in Denmark, 2019-2024.

METHODS: This Danish cohort study included 1 356 841 individuals aged 1-18 years. Socio-demographic and socio-economic factors for children and their parents were obtained from Statistics Denmark’s registers and linked to varicella vaccination status in the Danish Vaccination Register. We estimated yearly vaccination initiation and cumulative vaccine coverage. Associations were assessed using crude and adjusted multivariable logistic regression models.

RESULTS: As of 2024, 16 903 1-18 year olds had received at least one dose of the varicella vaccine, of whom 84% completed the series. Coverage increased markedly from 2019 to 2024 and was highest in the Capital Region and metropolitan municipalities. Vaccination was more likely among children of parents with higher education (aOR: 4.98, 95% CI: 4.05-6.12), higher income (aOR: 3.08, 95% CI: 2.85-3.33) and a background in medicine or nursing (aOR: 1.79, 95% CI: 1.72-1.88).

CONCLUSION: Varicella vaccination uptake is higher among children from families with high socio-economic status, and this pattern persists over a 6-year period.

PMID:42141828 | DOI:10.1111/apa.70593