Tag: nevin manimala

J Craniofac Surg. 2026 Jun 26. doi: 10.1097/SCS.0000000000013053. Online ahead of print.

ABSTRACT

PURPOSE: This study aimed to comprehensively analyze changes in condylar volume and position before and after bilateral sagittal split ramus osteotomy (BSSRO) in mandibular prognathism patients with and without asymmetry in the Surgery-First Approach (SFA).

METHODS: A retrospective study included 10 patients in the asymmetry group and 13 in the symmetry group who underwent BSSRO in SFA. Computed tomography scans were collected at preoperative (T0) and 6 months postoperative (T1) to measure the 3D condylar volume (CV) and condylar displacement and rotation. Measurements on the deviated side (DS) and nondeviated side (NDS) were performed at each time point. Three-dimensional changes of condylar volume, displacement distance, and rotation angle were analyzed over time and compared between sides and groups using appropriate statistical methods.

RESULTS: Significant CV reduction was observed on both sides in the symmetry group after surgery. The center of the condylar head moved anteriorly in the symmetry group postoperatively. Meanwhile, it moved significantly forward and laterally on DS and anteriorly on NDS in the asymmetry group after surgery. The long axis of the condylar head rotated anteriorly and inferiorly on both sides and in both groups in the sagittal and coronal planes. In the horizontal plane, outward rotation on the DS and inward rotation on the NDS were identified in the asymmetry group.

CONCLUSIONS: In patients with severe facial asymmetry undergoing BSSRO, baseline condylar dysplasia is associated with greater postoperative condylar resorption. The pattern of condylar head displacement and rotation in our study resembled OFA results rather than those of other SFA studies. These findings suggest that SFA in our center may produce a similar impact on condylar remodeling as OFA.

PMID:42359509 | DOI:10.1097/SCS.0000000000013053

J Craniofac Surg. 2026 Jun 26. doi: 10.1097/SCS.0000000000013116. Online ahead of print.

ABSTRACT

OBJECTIVES: The possible cytotoxic effect of Centella asiatica extract on human dermal fibroblast cells was examined in this cell culture experiment. The main objective was to determine its basic safety for potential use in oral tissue regeneration applications and to assess its biocompatibility in vitro.

METHODS: Dulbecco’s Modified Eagle Medium with fetal bovine serum was used to cultivate human dermal fibroblasts. Using the conventional MTT experiment, cell viability was quantitatively evaluated. At concentrations of 5, 10, 50, 100, 150, and 200 g/mL, Centella asiatica extract was applied to cell cultures. A positive cytotoxicity control was Triton X-100, while untreated cells were used as the negative control. To determine dose-response associations (P<0.05), statistical analyses used one-way ANOVA and nonlinear regression.

RESULTS: When compared directly to the untreated control group, treatment with Centella asiatica extract did not result in a statistically significant decrease in human fibroblast vitality at any evaluated concentration. In addition, there was no concentration-dependent cytotoxic effect, as validated by nonlinear regression analysis. Up to the highest experimental dose of 200 g/mL, cellular viability remained surprisingly stable and was absolutely noncytotoxic. On the other hand, Triton X-100 significantly reduced overall cell survival.

CONCLUSION: At concentrations as high as 200 g/mL, the Centella asiatica extract is completely biocompatible and does not harm healthy human dermal fibroblasts. Its prospective applicability for additional experimental and clinical studies aimed at improving oral soft tissue regeneration and wound healing is strongly supported by the absence of dose-dependent toxicity, confirming its outstanding safety profile.

PMID:42359507 | DOI:10.1097/SCS.0000000000013116

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2026 Jun 26:1-13. doi: 10.1080/10934529.2026.2692818. Online ahead of print.

ABSTRACT

Exposure to organochlorine pesticides (OCPs) may disrupt adolescent development; however, their precise impacts remain unclear. Using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2016, we examined associations between OCPs and adolescent body composition indicators, including body mass index (BMI) z_score, appendicular lean mass (ALM), trunk fat (TRF), total fat (TOF), total lean mass (TLM), and total percent fat (TPF). We fitted several statistical models including linear regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR). Mediation analysis evaluated the effect of serum albumin, while network toxicology and molecular docking identified key targets and pathways. Linear regression showed that OCPs were negatively correlated with BMI z_score, ALM, TRF, TOF, TLM, and TPF in adolescents, particularly in males. The WQS and BKMR revealed a negative relationship between OCPs mixtures and BMI z_score, TRF, TOF, and TPF, with hexachlorobenzene (HCB) as the major contributor. Albumin mediated the negative effects of HCB on all body composition indicators. Preliminary bioinformatics analyses suggested that HCB may influence body composition through inflammation, metabolic regulation, and apoptosis involving the MAPK, PI3K-Akt, and Ras signaling pathways. These findings suggest that HCB exposure may adversely affect adolescent growth and nutritional health, particularly among males.

PMID:42359500 | DOI:10.1080/10934529.2026.2692818

Biom J. 2026 Aug;68(4):e70145. doi: 10.1002/bimj.70145.

NO ABSTRACT

PMID:42359457 | DOI:10.1002/bimj.70145

Front Digit Health. 2026 Jun 10;8:1811259. doi: 10.3389/fdgth.2026.1811259. eCollection 2026.

NO ABSTRACT

PMID:42359447 | PMC:PMC13291121 | DOI:10.3389/fdgth.2026.1811259

Cureus. 2026 Jun 24;18(6):e111438. doi: 10.7759/cureus.111438. eCollection 2026 Jun.

ABSTRACT

Extramedullary disease (EMD) in multiple myeloma refers to soft-tissue plasmacytomas that spread hematogenously and grow independently of bone, an aggressive phenotype that has been associated with poorer responses and shorter survival across successive treatment eras. Bispecific antibodies are highly active in relapsed or refractory multiple myeloma (RRMM), but their efficacy in patients with baseline EMD has not been quantitatively synthesized. We performed a systematic review and meta-analysis, reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidance, of prospective trials of B-cell maturation antigen (BCMA)- or G protein-coupled receptor class C group 5 member D (GPRC5D)-directed CD3 bispecific antibodies in RRMM that reported the objective response rate (ORR) in patients with baseline EMD. One estimate per trial was included; proportions were pooled using a random-effects model on the logit scale with restricted maximum-likelihood estimation of between-study variance, and heterogeneity was assessed with the Cochran Q test and the I-squared statistic; fixed-effect and leave-one-out sensitivity analyses were performed, and risk of bias was appraised for each EMD subgroup. Four prospective studies comprising 144 patients with baseline EMD were included. Study-level ORRs were 58.3% for teclistamab, 38.5% for elranatamab, 52.6% for linvoseltamab, and 44.6% for talquetamab when recommended phase 2 dose cohorts were combined. The random-effects pooled ORR was 45.2% (95% CI, 37.2-53.4), with no observed between-study heterogeneity (I-squared = 0%); estimates were identical under a fixed-effect model, and leave-one-out pooled ORRs ranged narrowly from 44.0% to 47.6%. BCMA- and GPRC5D-directed bispecific antibodies produce objective responses in approximately half of patients with RRMM and baseline EMD, with broadly similar activity across agents despite high-risk biology, although the small number of trials and their differing, sometimes paramedullary-inclusive, definitions of EMD warrant caution in interpreting this estimate. These pooled estimates provide a benchmark for patient counseling and trial design and support combination strategies to improve outcomes in this population.

PMID:42359424 | PMC:PMC13293460 | DOI:10.7759/cureus.111438

Front Plant Sci. 2026 Jun 10;17:1810933. doi: 10.3389/fpls.2026.1810933. eCollection 2026.

ABSTRACT

INTRODUCTION: Restored estuarine floodplains with an artificially controlled reduced tide (CRT) are dynamic areas created for flood protection whilst also providing habitats for estuarine wildlife. However, the reintroduction of the tide poses stressors, including salinity and waterlogged soils because of periodic flooding, on established vegetation such as English oak (Quercus robur). Therefore, newly opened CRT areas give the opportunity of studying the effects of flooding, salinity, and drainage, on hydrogen peroxide (H₂O₂) concentrations in plants, as a proxy for stress.

METHODS: This was done on English oak samples retrieved from both field and mesocosm settings using commercially available peroxide assay kits.

RESULTS: Our results indicated that H₂O₂ concentrations measured in the field were affected by the time of sampling, while concentrations in the mesocosm were influenced by soil type. Flooding and salinity did not show detectable effects on H₂O₂ concentrations, either individually or in combination with soil type, within the scope of our experimental design, which had constrained statistical power to detect subtle effects. Additionally, our results did not correspond with the deterioration and mortality of English oak observed in the field and mesocosm experiments, indicating limited suitability of H₂O₂ as a standalone indicator of physiological stress under these conditions.

DISCUSSION: Overall, we recommend that future studies include a broader range of indicators to assess the tree stress responses in dynamic CRT environments.

PMID:42359418 | PMC:PMC13290460 | DOI:10.3389/fpls.2026.1810933

PCN Rep. 2026 Jun 24;5(2):e70367. doi: 10.1002/pcn5.70367. eCollection 2026 Jun.

ABSTRACT

AIM: Some features of neurodevelopmental disorders (NDDs) have been discussed as potential factors related to criminal behavior, and addressing their characteristics may help prevent recidivism among forensic patients. However, evidence from Japan remains limited. This study examined the association between NDDs and recidivism among forensic outpatients receiving treatment under Japan’s Medical Treatment and Supervision Act (MTSA).

METHODS: This retrospective cohort study used the national database of Japanese forensic outpatients who received treatment under the MTSA between 2005 and 2017. Generalized linear models analyzed the association between NDDs, including intellectual disability (ID), autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD), and recidivism during outpatient treatment.

RESULTS: A total of 2135 patients were included in the analysis, of whom 221 (10.4%) exhibited recidivism. ID, ASD, and ADHD were observed in 10.0%, 3.9%, and 0.3% of patients, respectively. Both ID (adjusted odds ratio [aOR] = 1.92, 95% confidence interval [CI]: 1.29-2.87) and ASD (aOR = 2.94, 95% CI: 1.64-5.27) were associated with an increased risk of recidivism. ID was associated with a higher risk of physical violence (aOR = 2.01, 95% CI: 1.28-3.14) and arson (aOR = 3.43, 95% CI: 1.01-11.71), whereas ASD was associated with physical violence (aOR = 2.87, 95% CI: 1.51-5.46).

CONCLUSION: Among Japanese forensic outpatients, ASD and ID were associated with an increased risk of recidivism during outpatient treatment. These findings highlight the importance of developing tailored support and multidisciplinary interventions that address the specific needs of individuals with NDDs.

PMID:42359389 | PMC:PMC13292018 | DOI:10.1002/pcn5.70367

Int J Nurs Stud Adv. 2026 Jun 9;11:100596. doi: 10.1016/j.ijnsa.2026.100596. eCollection 2026 Dec.

ABSTRACT

BACKGROUND: Spiritual care is a core element of holistic nursing, especially in demanding settings such as emergency and intensive care units where patients often face life-threatening conditions and end-of-life challenges. Despite its importance, little is known about nurses’ competence in providing spiritual care and the factors that shape it.

OBJECTIVE: This study aimed to explore spiritual care competence and its predictors among nurses working in critical and emergency settings.

DESIGN: A cross-sectional study.

SETTINGS: The study was conducted in the emergency and intensive care units of two central hospitals in Qazvin, Iran.

PARTICIPANTS: A total of 180 nurses working in critical care and emergency units participated in the study.

METHODS: Data were collected using the Spiritual Care Competence Scale, the Spiritual Intelligence Self-Report Inventory, and the Death Attitude Profile-Revised. Descriptive statistics and logistic regression analyses were performed using SPSS version 23.

RESULTS: Nurses demonstrated moderate levels of spiritual care competence (86.79 ± 4.25) and spiritual intelligence (57.15 ± 6.13). Among death attitude dimensions, neutral acceptance scored highest, while approach acceptance scored lowest. Logistic regression revealed that age, work experience, spiritual intelligence, and a positive attitude toward death were significant predictors of spiritual care competence (p < 0.05).

CONCLUSION: Spiritual care competence among nurses is associated with personal maturity, professional experience, spiritual intelligence, and positive attitudes toward death. Integrating spiritual care education and fostering positive perspectives on death may enhance nurses’ preparedness to deliver comprehensive, patient-centered care.

PMID:42359385 | PMC:PMC13292470 | DOI:10.1016/j.ijnsa.2026.100596

Dent Res J (Isfahan). 2026 May 14;23:15. doi: 10.4103/drj.drj_411_24. eCollection 2026.

ABSTRACT

BACKGROUND: Oral lichen planus (OLP) is a chronic mucocutaneous inflammatory disease that is somewhat frequently manifested in various clinical forms: reticular OLP (ROLP) and erosive OLP (EOLP), and some cases are associated with dysplasia. Higher risk of malignant transformation has been linked to dysplastic alterations in OLP. Glucose transporter protein (GLUT1) is a transmembrane glycoprotein associated with increased glucose metabolism and proliferation of cells. This study’s objective was to analyze and compare the expression patterns of GLUT1 in EOLP, ROLP, and lichen planus-related dysplasia in an attempt to acquire improved knowledge of the molecular pathways that underlie the etiology and advancement of OLP.

MATERIALS AND METHODS: In this retrospective study, analysis of GLUT1 expression was done in 32 samples of OLP (16 for ROLP, 10 for EOLP, and 6 for OLP with dysplasia) with immunohistochemistry. Statistical analysis was performed using Pearson’s Chi-square and F-tests, with significance set at P < 0.05. The immune GLUT-1 expression was evaluated semi-quantitatively and qualitatively at ×100 magnification.

RESULTS: The mean percentage of GLUT1-positive cells in ROLP (16.53 ± 11.72) was lower than that in EOLP and OLP with dysplasia. Among the three groups, there was a significant difference in terms of staining intensity, intracellular location, and extent of GLUT1 immunoexpression within the epithelium layers (0.000, 0.034, and 0.006, respectively).

CONCLUSION: GLUT1 overexpression reflects increased glycolytic activity of proliferating cells in response to hypoxia and high energy requirements in EOLP and OLP-related dysplasia. GLUT1 expression may predict the malignant potential of OLP toward oral squamous cell carcinoma.

PMID:42359380 | PMC:PMC13293537 | DOI:10.4103/drj.drj_411_24