Tag: nevin manimala

JAMA Health Forum. 2025 Aug 1;6(8):e253014. doi: 10.1001/jamahealthforum.2025.3014.

ABSTRACT

IMPORTANCE: Transgender and gender diverse (TGD) people have significantly higher rates of cardiovascular-related conditions than cisgender people, and Black and Hispanic people have higher rates of cardiovascular-related conditions than non-Hispanic White people. However, little is known about the prevalence of cardiovascular-related conditions among racial and ethnic subgroups of TGD people.

OBJECTIVE: To compare the prevalence of cardiovascular-related conditions across racial and ethnic groups for TGD and cisgender people using quantitative intersectional methods.

DESIGN, SETTING, AND PARTICIPANTS: Medicare enrollment and claims data were used from TGD and cisgender beneficiaries from 2011 to 2020. Using an established algorithm, likely TGD people were identified based on their diagnosis codes and care utilization. The 10 nearest-neighbor cisgender matches for each TGD beneficiary were identified based on propensity scores estimated from the original basis of eligibility, years of enrollment, age, and hospital service area.

EXPOSURE: Race, ethnicity, and gender modality (TGD and cisgender). These data were analyzed from November 7, 2023, to October 31, 2024.

MAIN OUTCOMES AND MEASURES: Rate of cardiovascular-related conditions (peripheral vascular disease, congestive heart failure, diabetes, hypertension, and chronic obstructive pulmonary disease) among Asian and Pacific Islander, Black, and Hispanic TGD beneficiaries compared with non-Hispanic White cisgender counterparts using generalized estimating equations, cardiovascular diseases and their risk factors. Attributable proportions for TGD Asian and Pacific Islander, Black, and Hispanic beneficiaries were calculated.

RESULTS: Of the 36 004 TGD beneficiaries, 714 Asian and Pacific Islander (2%), 4518 Black (13%), and Hispanic 2545 (7%) had higher rates of cardiovascular-related conditions than 28 227 non-Hispanic White (78%) beneficiaries and higher than the 323 613 cisgender beneficiaries (5981 Asian and Pacific Islander [2%]; 40 781 Black [13%]; 22 417 Hispanic [7%]; 254 434 White [79%]). Black TGD beneficiaries had a 74% higher prevalence of peripheral vascular disease, 76% higher prevalence of congestive heart failure, and 50% higher prevalence of diabetes than similar non-Hispanic White cisgender beneficiaries. Overall, 6.3% of the excess peripheral vascular disease among Black TGD beneficiaries and 19.9% of the excess peripheral vascular disease among Asian and Pacific Islander TGD beneficiaries were associated with being at the intersection of gender, race, and ethnicity.

CONCLUSIONS AND RELEVANCE: This cross-sectional study found that Asian and Pacific Islander, Black, and Hispanic TGD beneficiaries had a high prevalence of cardiovascular-related conditions and had an elevated prevalence of several conditions, attributable to the intersection of gender, race, and ethnicity. Medicare should use the tools at its disposal to support the health of TGD beneficiaries.

PMID:40844770 | DOI:10.1001/jamahealthforum.2025.3014

Spine (Phila Pa 1976). 2025 Aug 22. doi: 10.1097/BRS.0000000000005480. Online ahead of print.

ABSTRACT

STUDY DESIGN: A retrospective cohort analysis.

OBJECTIVE: This study investigates the association between initial postoperative gabapentinoid prescription and long-term opioid use following long-segment posterior lumbar instrumentation.

SUMMARY OF BACKGROUND DATA: Gabapentinoids have gained traction for their neuropathic pain-relieving properties and potential synergy with opioids. However, their long-term efficacy in minimizing postoperative opioid consumption remains uncertain, particularly in patients undergoing extensive spinal surgery.

METHODS: The TriNetX Research Network was queried to identify patients with preoperative diagnoses of lumbar spinal stenosis, spondylolisthesis or scoliosis who underwent posterior lumbar instrumentation spanning 3 to 12 vertebral segments. The study population was stratified by based on the extent of instrumentation, defined as either 3-6 or 7-12 spinal segments. These patients were further divided into two cohorts: those who were prescribed a gabapentinoid (gabapentin or pregabalin) within 30 days postoperatively and those who were not. To address potential confounders, 1:1 propensity score matching (PSM) was performed, adjusting for demographics, comorbidities, and preoperative prescriptions of opioids and gabapentinoids. Presence of select postoperative opioid prescriptions were assessed at 1 to 3 months, 3 to 6 months, 6 to 12 months, and 12 to 24 months.

RESULTS: A total of 28,827 patients met all initial inclusion criteria. Following 1:1 PSM, the 3-6 segment group included 1,816 patients per cohort and the 7-12 segment group consisted of 344 patients per cohort. Among 3-6 level instrumentations, patients who received gabapentinoids within 30 days of surgery demonstrated significantly lower odds of being prescribed non-codeine-based and strong opioids at all postoperative intervals. In contrast, these gabapentinoid-treated patients exhibited higher odds of weak opioid prescriptions at 3 to 6 months. No statistically significant difference in opioid prescribing was observed among 7-12 segment instrumentation patients at any period.

CONCLUSION: This study demonstrates that early postoperative gabapentinoid prescription is associated with a sustained reduction in chronic non-codeine-based and strong opioid use following 3-6 segment lumbar fusion. These findings underscore the utility of gabapentinoids as part of a multimodal analgesia strategy, potentially minimizing the need for more potent opioids and reducing the risk of long-term dependence in spine surgery patients.

PMID:40844769 | DOI:10.1097/BRS.0000000000005480

Proc Natl Acad Sci U S A. 2025 Aug 26;122(34):e2507516122. doi: 10.1073/pnas.2507516122. Epub 2025 Aug 22.

ABSTRACT

Humans can implicitly learn about multistep sequential relationships between events in the environment from their statistical co-occurrence. Theoretical work has suggested that neural replay is a candidate mechanism that aids such learning. Here, we used functional MRI (fMRI) to test whether replay is related to implicit learning of higher-order sequential relationships. Human participants viewed sequences of images that followed probabilistic transitions determined by ring-like graph structures. Behavioral modeling of response times revealed that participants acquired multistep transition knowledge in a manner consistent with gradual updating of an internal successor representation (SR) model. Yet, half of participants did not report being aware of any sequential task structure, and most participants failed to provide meaningful transition probability ratings in a posttask test. Analyses of temporal dynamics of multivariate fMRI patterns during brief 10 s pauses from the ongoing statistical learning task indicated backward sequential replay of multistep sequences in visual cortical areas. Variations in model parameters between participants that captured response time patterns related to strength of neural replay. No corresponding relations between replay and measures of explicit awareness were found. These findings indicate that implicit learning of higher-order relationships establishes an internal SR-based map of the task and is accompanied by cortical on-task replay.

PMID:40844766 | DOI:10.1073/pnas.2507516122

Eur Radiol. 2025 Aug 22. doi: 10.1007/s00330-025-11859-9. Online ahead of print.

NO ABSTRACT

PMID:40844754 | DOI:10.1007/s00330-025-11859-9

Eur Radiol. 2025 Aug 22. doi: 10.1007/s00330-025-11960-z. Online ahead of print.

NO ABSTRACT

PMID:40844753 | DOI:10.1007/s00330-025-11960-z

Eur Radiol. 2025 Aug 22. doi: 10.1007/s00330-025-11959-6. Online ahead of print.

NO ABSTRACT

PMID:40844752 | DOI:10.1007/s00330-025-11959-6

Eur Radiol. 2025 Aug 22. doi: 10.1007/s00330-025-11877-7. Online ahead of print.

NO ABSTRACT

PMID:40844751 | DOI:10.1007/s00330-025-11877-7

Eur Radiol. 2025 Aug 22. doi: 10.1007/s00330-025-11875-9. Online ahead of print.

NO ABSTRACT

PMID:40844750 | DOI:10.1007/s00330-025-11875-9

Cardiovasc Drugs Ther. 2025 Aug 22. doi: 10.1007/s10557-025-07759-1. Online ahead of print.

ABSTRACT

PURPOSE: The optimal dosing strategy for direct oral anticoagulants (DOACs) in extended treatment of venous thromboembolism (VTE) remains debated, particularly in balancing efficacy and bleeding risk.

METHODS: A systematic review and meta-analysis was performed to compare reduced-dose versus full-dose DOACs for extended VTE treatment. Databases including PubMed, Embase, and Cochrane Library were searched from inception to March 2025 for randomized controlled trials (RCTs) involving adult patients treated with different DOAC doses for VTE. Primary outcomes were recurrent VTE, major or clinically relevant non-major bleeding, and all-cause mortality. Subgroup analysis was conducted by DOAC type (apixaban vs. rivaroxaban).

RESULTS: Pooled data from 4 studies involving 8421 patients showed no statistically significant difference in recurrent VTE risk between reduced-dose and full-dose DOACs (RR = 0.94; 95% CI, 0.64-1.37; p = 0.75). Bleeding events were significantly lower in the reduced-dose group compared to the full-dose group (RR = 0.71; 95% CI, 0.61-0.82, p < 0.00001). All-cause mortality did not differ significantly between groups (RR = 0.80; 95% CI, 0.54-1.18; p = 0.25). Subgroup analysis showed consistent findings across DOAC type, with no significant interaction effects.

CONCLUSION: Reduced-dose DOACs appear to be as effective as full-dose DOACs in preventing VTE, with a favorable safety profile due to reduced bleeding risk. These findings support reduced-dose DOACs as a viable option for extended anticoagulation in VTE patients.

PMID:40844745 | DOI:10.1007/s10557-025-07759-1

J Neurol. 2025 Aug 22;272(9):587. doi: 10.1007/s00415-025-13328-1.

ABSTRACT

BACKGROUND: Primary Lateral Sclerosis (PLS) is a rare, adult-onset neurodegenerative disease that predominantly affects upper motor neurons. Despite being considered mostly sporadic, familial cases and rare genetic variants in genes associated with amyotrophic lateral sclerosis, hereditary spastic paraplegia and other neurological disorders have been reported in some PLS cases. Due to its rare prevalence among general population, large genetic studies of PLS are lacking.

METHODS: Fifty patients diagnosed with PLS based on consensus criteria were enrolled between 2013 and 2022 for comprehensive phenotypic and genotypic analysis using whole genome sequencing. We analyzed rare single nucleotide variants (SNVs), deemed pathogenic, likely pathogenic or of uncertain significance (VUS) based on the American College of Medical Genetics and Genomics criteria, and repeat expansions (REs) exceeding the pathogenic threshold, in 290 genes involved in neurological disorders.

RESULTS: We identified mutations in 7 patients (13.7%), specifically SNVs in CAPN1 (Spastic paraplegia 76), TBK1 (amyotrophic lateral sclerosis/frontotemporal dementia, ALS4/FTD), LITAF (Charcot-Marie-Tooth disease 1C), POLG (chronic progressive external ophthalmoplegia), APP (Alzheimer’s disease) and OPTN (ALS12 ± FTD), and one RE in ATXN8OS (spinocerebellar ataxia 8). Additionally, two VUS were found in ANTXR2, a candidate gene for PLS recently identified via truncating variant collapsing analysis, but none of them was loss-of-function (one synonymous and one in-frame insertion).

CONCLUSIONS: Our study demonstrates a notable genetic intersection between PLS and various neurological disorders, including motor neuron diseases, neuropathies, mitochondrial disorders, ataxias, and dementias. These findings underscore the relevance of further investigation in larger cohorts to fully elucidate PLS genetic architecture and highlight the need to reconsider the role of genetic testing in its diagnostic criteria.

PMID:40844737 | DOI:10.1007/s00415-025-13328-1