Tag: nevin manimala

Matern Child Health J. 2025 Jan 22. doi: 10.1007/s10995-025-04057-y. Online ahead of print.

ABSTRACT

OBJECTIVE: The study aimed to evaluate the quality of life (QoL) of caregivers of children diagnosed with CZS and to assess the association of findings with socioeconomic and CZS-associated variables.

METHODS: This was a cross-sectional, quantitative study, carried out over three days of multidisciplinary care for patients with CZS. Sixty-four participants underwent a quality of life assessment using the World Health Organization Quality of Life questionnaire (WHOQOL-BREF) in Portuguese.

RESULTS: Both groups of caregivers attributed regular scores for Global QoL, and all WHOQOL-BREF domains. Among caregivers of children with CZS, QoL correlated with three of the four WHOQOL-BREF domains (psychological health: rho = 0.49, p < 0.001; social relationships: rho = 0.28, p < 0.023; and environment: rho = 0.11, p < 0.006), while general health perception correlated with three other domains (physical health: rho = 0.49, p < 0.001; psychological health: rho = 0.31, p < 0.012; and social relationships: rho = 0.30, p < 0.016). The environment domain was associated with the level of education in this population (p < 0.001). Macular scarring and focal pigmentary retinal mottling were significantly associated with the physical environment (p = 0.039), negative feelings (p = 0.035), support and social aid (p = 0.020).

CONCLUSION: The present study demonstrates that the WHOQOL-BREF is an effective method to evaluate the general perception of QoL among caregivers of children with CZS. Our results also suggest that caregivers of children with CZS do not experience a reduced quality of life compared to caregivers of typically developing children.

PMID:39841322 | DOI:10.1007/s10995-025-04057-y

Lasers Med Sci. 2025 Jan 22;40(1):27. doi: 10.1007/s10103-024-04243-4.

ABSTRACT

OBJECTIVE: This study aims to quantitatively compare the effects of standard needle irrigation (SNI), passive ultrasonic irrigation (PUI), EDDY, photon-initiated photoacoustic streaming (PIPS), and shock wave-enhanced emission photoacoustic streaming (SWEEPS) on the apical extrusion of irrigation solutions in teeth with severe canal curvature.

MATERIALS AND METHODS: Seventy-five teeth with a single root and canal, and curvature angles ranging from 20° to 40°, were selected for this study. Root canal curvatures were measured from buccolingual and mesiodistal radiographs using ImageJ software (version 1.48v; National Institutes of Health, Bethesda, MD, USA). The samples were randomly assigned to five groups (n = 15) based on the irrigation activation methods: SNI, PUI, EDDY, PIPS, and SWEEPS. An irrigation activation procedure was performed for 90 s using a total of 6 ml of 2.5% sodium hypochlorite (NaOCl) (Wizard, Istanbul, Turkey) in all samples. The Myers-Montgomery experimental model was used to simulate periapical tissues and limit the amount of extruded solution. The extruded irrigation solution was collected from the drainage cannula using an insulin syringe.

RESULTS: The data on the amount of apical extrusion of irrigation solution were analyzed statistically using the Kruskal-Wallis and Mann-Whitney U tests, with a significance level set at P < 0.05. While the highest mean solution extrusion was observed in the SNI and PUI groups, the PIPS group showed less extrusion compared to the other groups. However, no statistically significant difference in the amount of apical extrusion of irrigation solution was found among all the irrigation activation methods tested.

CONCLUSIONS: Within the limitations of this study, all irrigation activation methods tested on teeth with severe curvature resulted in a certain amount of solution extrusion. However, no significant difference was identified among the irrigation activation methods tested.

CLINICAL RELEVANCE: When these irrigation activation methods are tested on teeth with varied canal anatomies, the amount of apical extrusion of the irrigation solution may vary.

PMID:39841307 | DOI:10.1007/s10103-024-04243-4

Clin Oral Investig. 2025 Jan 22;29(1):74. doi: 10.1007/s00784-024-06128-w.

ABSTRACT

OBJECTIVE: To evaluate the possible additional clinical benefit from autologous platelet concentrate (APC) treatment adjunct to non-surgical periodontal therapy (NSPT).

METHODS: Electronic (MEDLINE/Embase/Cochrane/MedNar/CORE) and hand searches were conducted. Following studies selection, evidence tables were formed, and meta-analyses were performed for the following outcomes: probing pocket depth (PPD) reduction, clinical attachment level (CAL) gain, and bleeding on probing (BoP) reduction. The protocol for this systematic review was registered in PROSPERO (CRD42023514388).

RESULTS: After de-duplication, the initial search yielded 194 citations, from which ten papers were eligible for quantitative synthesis. The APC group comprised 270 patients, while the control group included 230. The meta-analysis revealed that a single APC application resulted in a 0.6 mm greater PPD reduction (MD = -0.62; 95% CI: -1.03, -0.22) and 0.8 mm more CAL gain (MD = -0.77; 95% CI: -1.18, -0.37) at the 6-12 weeks follow-up. At six months, the APC group exhibited a 0.6 mm greater PPD reduction (MD = -0.61; 95% CI: -1.13, -0.09) and 1.1 mm more CAL gain (MD = -1.14; 95% CI: -1.94, -0.34) compared to the NSPT only group. In contrast, BoP indices did not reveal a statistically significant difference between the groups after 6-12 weeks (MD = -10.54; 95% CI: -25.21, 4.14). High heterogeneity and unclear to high risk of bias were detected.

CONCLUSION: Over six months, the adjunctive APC use appears to provide additional benefits in PPD reduction and CAL gain compared to NSPT alone.

CLINICAL RELEVANCE: The adjunctive use of APCs seems to promote further improvements in clinical outcomes following NSPT.

PMID:39841297 | DOI:10.1007/s00784-024-06128-w

Lung. 2025 Jan 22;203(1):30. doi: 10.1007/s00408-024-00784-1.

ABSTRACT

BACKGROUND: Guidelines specify steroids as therapy for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the duration of survival benefit associated with steroids and the optimal dosage of nebulized budesonide (NB) during hospitalization remain unclear.

METHODS: We conducted a retrospective study of hospitalized AECOPD patients. The primary endpoint was all-cause mortality after discharge. Cox regression analysis was used to determine the impact of steroid therapy on survival.

RESULTS: Wilcoxon analysis showed the positive impact of systemic corticosteroids (SCs) therapy on survival during the early stage of follow-up (P = 0.038). NB therapy was associated with a significantly reduced risk of death within six months after discharge (adjusted Hazard ratio (HR), 0.36; 95% confidence interval (CI) 0.15-0.88). Subgroup analysis suggested that fewer than two AEs in the previous year (adjusted HR 0.05; 95% CI 0.01-0.38), age > = 65 years (adjusted HR 0.31; 95% CI 0.11-0.90), body mass index (BMI) < 25 kg/m² (adjusted HR 0.33; 95% CI 0.12-0.92), and smoking index > 40 packets/year (adjusted HR 0.17; 95% CI 0.04-0.79) were involved in this association. Finally, treatment with a total dose of NB < = 60 mg during hospitalization reduced six-month mortality compared to treatment without steroids (adjusted HR 0.39; 95% CI 0.17-0.92), but not the total dose of NB > 60 mg.

CONCLUSIONS: NB therapy for hospitalized AECOPD patients significantly reduced six-month mortality. Subgroup analysis showed that certain populations benefited more from NB therapy, and < = 60 mg NB might be suitable treatment for hospitalized AECOPD patients.

PMID:39841274 | DOI:10.1007/s00408-024-00784-1

Environ Monit Assess. 2025 Jan 22;197(2):180. doi: 10.1007/s10661-025-13616-3.

ABSTRACT

In this study, an efficient membrane composed of polysulfone and graphene oxide was developed and evaluated for its efficacy in chromium adsorption. Characterization of the synthesized membrane involved comprehensive analyses including scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA) and Fourier-transform infrared spectroscopy (FTIR) to assess its structural properties. Subsequently, the membrane’s performance in removing chromium from aqueous solutions was scrutinized, considering key operational parameters. Response surface methodology (RSM) based on central composite design (CCD) was employed to optimize parameters. Additionally, the pH parameter revealed the most significant (F-value = 184.25) on the amount of chromium removal by the membrane process. The interaction between pH and contact time is the most significant among all interactions, with an F-value of 40.99. Moreover, the high R² (97.58%) and adjusted R² (95.41%) indicate the model effectively explains variance with minimal overfitting, confirming its strong predictive capability. Under optimized conditions (pH 5, initial concentration of 30 mg/L, and contact time of 40 min), the polysulfone/graphene oxide membrane exhibited an impressive removal efficiency of 81.1%. This study highlights the potential of polysulfone/graphene oxide membranes in effectively separating chromium from aqueous mediums, thereby suggesting a promising avenue for future research in addressing heavy metal pollution.√.

PMID:39841272 | DOI:10.1007/s10661-025-13616-3

Clin Oral Investig. 2025 Jan 22;29(1):72. doi: 10.1007/s00784-024-06093-4.

ABSTRACT

OBJECTIVES: This study aimed to assess the vertical misfit at the implant-abutment interface in external and internal connections across various implant brands, comparing original milled titanium abutments with laser-sintered cobalt-chromium (Co-Cr) abutments.

MATERIALS AND METHODS: A total of 160 implants from four different brands were utilized, with 80 featuring external connections (EC) and 80 internal connections (IC). Original milled titanium abutments (n = 160) and Co-Cr laser-sintered abutments (n = 160) were randomly attached to each connection type, following the manufacturer’s recommended torque. After undergoing thermal cycling, the vertical misfit was measured using a scanning electron microscope. Statistical analyses were performed using the Kruskal-Wallis and Mann-Whitney U tests. The significance level was set at α = 0.05.

RESULTS: The original milled titanium abutments exhibited the lowest misfit values. Significant differences were identified between both abutment types for EC (d = 109.578 μm; p = 0.0001) and IC (d = 44.317 μm; p = 0.002). The EC with laser-sintered abutments demonstrated the highest marginal misfit values, with an average of nearly 30 μm, while a misfit value of 11.382 μm was achieved in the IC. Differences were observed among the brands for milled abutments in both EC and IC. Similarly, variations were also noted for the laser-sintered Co-Cr abutments in EC and IC configurations.

CONCLUSIONS: The vertical misfit of the original milled titanium abutments in all groups was within the clinically acceptable range for IC. The connection type significantly impacted the vertical misfit in laser-sintered Co-Cr abutments. Differences among the implant systems were observed for both connection types and abutment types evaluated.

CLINICAL RELEVANCE: Using original milled titanium abutments, particularly in internal connection systems, can lead to better fit and stability at the implant-abutment interface, potentially reducing the risk of mechanical complications and improving long-term implant success.

PMID:39841269 | DOI:10.1007/s00784-024-06093-4

Clin Oral Investig. 2025 Jan 22;29(1):73. doi: 10.1007/s00784-024-06105-3.

ABSTRACT

OBJECTIVES: This study analyzed the differences in the upper airway of patients with skeletal Class III high-angle malocclusion with and without mandibular deviation, and further investigated whether there are differences in the changes in upper airway space after orthognathic surgery between the two groups.

MATERIALS AND METHODS: 15 patients with skeletal Class III high-angle malocclusion and mandibular deviation, and 15 patients without mandibular deviation were selected to explore the impact of mandibular deviation on the upper airway. Additionally, 16 patients with mandibular deviation undergoing orthodontic-orthognathic combined treatment, and 13 patients without mandibular deviation, were selected to investigate the differences in the changes in upper airway space after orthognathic surgery between the two groups.

RESULTS: In patients with skeletal Class III high-angle malocclusion, the deviation group showed significantly smaller sagittal diameter/maximum transverse diameter, cross-sectional area, volumes of oropharynx and hypopharynx, and total volume compared to the normal group, with all differences being statistically significant. After orthognathic surgery, the postoperative sagittal diameter/maximum transverse diameter of the oropharyngeal airway increased in the deviation group, while it decreased in the normal group. The postoperative reductions in cross-sectional area, volumes, and total volume of the oropharynx and hypopharynx were more pronounced in the normal group.

CONCLUSION: In patients with skeletal Class III high-angle malocclusion, mandibular deviation results in narrowing of the lower portion of the upper airway. The orthognathic surgical correction of mandibular deviation compensates to some extent for the reduction in the cross-sectional area and volume of the upper airway caused by the surgery itself.

CLINICAL RELEVANCE: For patients with skeletal Class III high-angle malocclusion with mandibular deviation, a thorough assessment of the upper airway should precede the selection of orthognathic surgery procedures. For patients with normal preoperative upper airway morphology, consideration may prioritize correction of facial aesthetics and occlusion. For patients with pre-existing narrow upper airways, as mandibular setback exacerbates narrowing and the compensatory effect of mandibular deviation correction on the airway is limited, it is suggested that these patients prioritize bimaxillary surgery or reduce the amount of mandibular setback to better promote postoperative respiratory function health.

PMID:39841256 | DOI:10.1007/s00784-024-06105-3

Pediatr Radiol. 2025 Jan 22. doi: 10.1007/s00247-024-06107-z. Online ahead of print.

ABSTRACT

BACKGROUND: Splenic stiffness is a potential imaging marker of portal hypertension. Normative spleen stiffness values are needed to define diagnostic thresholds.

OBJECTIVE: To report stiffness measurements of the spleen in healthy children undergoing liver magnetic resonance (MR) elastography across MRI vendors and field strengths.

MATERIALS AND METHODS: This was a post-hoc analysis of data collected under a prospective multicenter cross-sectional study. Volunteers aged 7-17.9 years without a known history of liver or spleen disease were recruited for a research MRI between February 2018 and October 2019. Gradient recalled echo (GRE) or spin-echo-echo-planar imaging (SE-EPI) MR elastography was performed on a total of three vendor platforms and at two field strengths (1.5 T (T) and 3 T) with standard right upper quadrant passive driver placement (frequency of 60 Hz). Two independent reviewers measured spleen stiffness, length, and volume. Descriptive statistics, independent sample t-tests or Mann-Whitney test, and Pearson’s or Spearman’s correlation were used.

RESULTS: From 101 study volunteers, 72 (34 female) had measurable splenic stiffness. Median age was 12 years (interquartile range [IQR], 9.9-14.9 years). Mean (± SD) spleen stiffness was 4.7 ± 0.9 kPa (IQR, 3.8-5.4 kPa) with 6.1 kPa reflecting the 95th percentile. Strong correlation was observed between reviewers (ICC = 0.89 [95%CI, 0.71-0.93; P < 0.001]). Male volunteers had slightly higher splenic stiffness compared to females: 4.9 ± 0.9 vs. 4.3 ± 0.8 kPa (P = 0.014). There was significant correlation between spleen stiffness and body mass index (r = 0.33 [95%CI, 0.06-0.56; P = 0.024]) but no other measure of patient size (r = 0.15-0.29). No significant difference in spleen stiffness was observed across vendors (P = 0.089) or field strengths (P = 0.236).

CONCLUSION: MR elastography-based spleen stiffness, measured as part of a liver MR elastography acquisition, is < 6.1 kPa in a healthy pediatric population and does not vary with MRI vendor or field strength.

PMID:39841253 | DOI:10.1007/s00247-024-06107-z

Eur Spine J. 2025 Jan 22. doi: 10.1007/s00586-024-08626-7. Online ahead of print.

ABSTRACT

PURPOSE: The purpose of this study was to investigate the outcomes of minimally invasive PCF using an interfacet joint fusion cage.

METHODS: The inclusion criteria consisted of patients who underwent a PCF using an interfacet device (Cavux, Providence Medical Technology Inc.) at a single institution and were at least 6 months postoperative. Charts were reviewed for pre-, intra- and postoperative data including arm and neck pain scores, Neck Disability Index (NDI), complications, and reoperations.

RESULTS: A consecutive series of 51 patients were included. Mean age was 54.9 years and 72.6% of patients (n = 37) were female. Most patients (n = 39, 76.5%) had a prior anterior cervical fusion resulting in pseudarthrosis. In total, 157 interfacet devices were implanted in 79 levels. There was statistically significant improvement from pre- to postoperative arm pain (3.8 vs. 2.4), neck pain (6.2 vs. 4.0), and NDI (42.2 vs. 34.9). With the exception of neck pain, these changes would not generally be considered clinically relevant. Ten (19.6%) reoperations occurred, with 4 (7.8%) involving interfacet device removal. The removals were due to: nonunion, device malpositioning, osteophytic overgrowth, trauma, and implantation of additional posterior instrumentation.

CONCLUSION: Performing a minimally invasive facet fusion may be an effective option for treating patients with a history of nonunion. Although the reoperation rate was high in this challenging cohort, only 4 out of 10 reoperations required device removal. More research is warranted to refine indications for this procedure and review larger samples of patients.

PMID:39841223 | DOI:10.1007/s00586-024-08626-7

Eur Spine J. 2025 Jan 22. doi: 10.1007/s00586-025-08643-0. Online ahead of print.

ABSTRACT

OBJECTIVE: To assess the efficacy and safety of subcutaneous perispinal infiltration of low dose of triamcinolone and lidocaine indicated for pain control in patients with cervical osteoarthritis (COA).

METHODS: Patients with symptomatic COA resistant to conventional treatment including anti-inflammatory drugs, analgesics, and physical therapy were included. Technetium-99 m pyrophosphate (99mTc-PYP) scintigraphy and computerized tomography (CT) fusion scans images were used for diagnosis of COA and as a guide for level(s) of infiltration(s). Infiltration consisted of subcutaneous administration of 1 cc of a mixture of triamcinolone (6 mg/0.7 cc) and 2% lidocaine (6 mg/0.3 cc) into the posterior central interspinal area, at the levels where the greatest uptake of the radiotracer was observed. Response was assessed using a pain analogue scale (PAS) (range 0-10 with 10 representing worst pain).

RESULTS: Forty-two patients were included. Thirty-six (85.7%) were women. The mean age was 59.2 years. Three months after infiltration clinical improvement was confirmed by a decrease in the PAS value: before and after infiltrations was 7.26 (range 4-10, SD:1.48) and 1.97 (range 0-6, SD:1.24), respectively. This difference being statistically significant (P < 0.05). No patient presented local or systemic adverse effects.

CONCLUSIONS: Low dose subcutaneous perispinal injection of triamcinolone and lidocaine may offer clinical benefits for patients with symptomatic COA refractory to conventional treatments. 99mTc-PYP/CT fusion scans images were useful as a guide for localization of infiltrations.

PMID:39841221 | DOI:10.1007/s00586-025-08643-0