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Nevin Manimala Statistics

Efficacy of a 10-MDP-Containing Cleaner on the Bond Strength to Saliva Contaminated Dentin

J Esthet Restor Dent. 2026 Apr 30. doi: 10.1111/jerd.70175. Online ahead of print.

ABSTRACT

OBJECTIVES: To evaluate the effect of saliva contamination and a 10-MDP-containing cleaner (Katana Cleaner; Kuraray Noritake, Japan) on the shear bond strength (SBS) of an ultra-mild universal adhesive applied in self-etch mode to human dentin.

MATERIALS AND METHODS: Mid-coronal dentin of extracted molars was prepared with standardized smear layers and assigned to four groups: control (SU), saliva-contaminated (C + SU), cleaner-treated (K + SU), and saliva-contaminated plus cleaner-treated (C + K + SU). Each group was evaluated either after 24 h storage or after artificial aging by 20,000 thermal cycles (designated “+A”). SBS was measured using a universal testing machine, failure modes were classified, and dentin surfaces were examined by SEM. Data were analyzed with three-way and one-way ANOVA and Bonferroni post hoc tests (α = 0.05).

RESULTS: SBS ranged from 9.69 ± 6.03 MPa (C + SU + A) to 16.98 ± 6.53 MPa (SU + A). Saliva contamination significantly reduced SBS after aging (p = 0.002). The cleaner had no significant effect on immediate or long-term bond strength, and aging alone was not statistically significant. Failures were predominantly adhesive at dentin (63.3%). SEM analysis revealed partial collagen exposure with cleaner or adhesive use, but smear plugs remained intact.

CONCLUSIONS: Saliva contamination compromised the long-term performance of the universal adhesive. The 10-MDP-containing cleaner did not restore bond strength but also did not adversely affect bonding to dentin.

CLINICAL SIGNIFICANCE: Saliva contamination is a critical factor that compromises the durability of adhesive restorations and should be strictly avoided. When contamination occurs, decontamination agents that do not adversely affect tooth structure or interfere with adhesion may be useful. The 10-MDP-containing cleaner tested in this study was safe for dentin and showed a trend toward mitigating the effects of saliva contamination, although it did not fully restore bond strength.

PMID:42059156 | DOI:10.1111/jerd.70175

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Nevin Manimala Statistics

The Impact of the Geriatric Emergency Department Initiative on Older Community Dwelling Adults Presenting to the Emergency Department With a Completed Delirium Screen

Emerg Med Australas. 2026 Jun;38(3):e70266. doi: 10.1111/1742-6723.70266.

ABSTRACT

OBJECTIVE: Australia’s ageing population resulted in increasing Emergency Department (ED) presentations among older adults, particularly frail and those at risk of adverse outcomes. Delirium contributes significantly to morbidity in this cohort. The 4AT screening tool is routinely employed to identify risk. This study examined the impact of the Geriatric Emergency Department Initiative (GEDI) on clinical outcomes for older community dwelling adults presenting to ED with a completed 4AT.

METHODS: A retrospective, single-centre observational cohort study was conducted at an urban district ED. Patients ≥ 75 years, and First Nations peoples ≥ 55 years, with a completed 4AT presenting between January 1 and June 30, 2023 were included. Data were extracted and analysed using descriptive and comparative statistics.

RESULTS: Of 1756 patients, 918 (52%) received GEDI input. Overall, 1135 (65%) had a 4AT score of 0 (no cognitive impairment), 410 (23%) with 4AT of 1-3 (mild cognitive impairment), and 211 (12%) with 4AT score of ≥ 4 (probable delirium). Among patients with a 4AT of 0, GEDI involvement was associated with shorter ED lengths of stay, lower admission rates, and higher discharges home (all p < 0.001). Patients with 4AT scores 1-3, GEDI involvement lowered admission rates, increased discharges home, with no difference in ED length of stay. No significant differences were observed with 4AT scores ≥ 4 when compared to standard care.

CONCLUSIONS: GEDI involvement reduced ED length of stay and admission rates among older adults without delirium or with mild cognitive impairment, but no significant impact was observed for patients with probable delirium.

PMID:42059151 | DOI:10.1111/1742-6723.70266

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Trajectory-Defined Thrombo-Inflammatory Phenotypes Predict 30-Day ICU Mortality in Post-cardiac Arrest Syndrome: A Multicenter Retrospective Longitudinal Cohort Study

Inquiry. 2026 Jan-Dec;63:1. doi: 10.1177/00469580261448815. Epub 2026 Apr 30.

ABSTRACT

Current risk stratification for Post-cardiac Arrest Syndrome (PCAS) relies mainly on static admission variables and may fail to capture the dynamic systemic evolution. This study aimed to identify trajectory-defined thrombo-inflammatory phenotypes in PCAS using longitudinal trajectories of platelets, white blood cells (WBC), hemoglobin, and body temperature, and to evaluate their association with 30-day ICU mortality. We conducted a multicenter retrospective cohort study using the MIMIC-IV, MIMIC-III, and eICU-CRD databases, including adult patients with ICU stays of 2-90 days after cardiac arrest. A Multivariate Process Joint Latent Class Mixed Model (mJLCMM) identified latent classes from 30-day biomarker trajectories. The primary outcome was 30-day ICU mortality. Associations were evaluated using Inverse Probability Weighting (IPW) and Doubly Robust Estimation (DRE). Prognostic accuracy was compared against SOFA and OASIS scores using time-dependent Receiver Operating Characteristic (ROC) analysis. A total of 5,099 patients were included. Two phenotypes were identified: Class 1 (“Rapid Decline and Recovery”) and Class 2 (“Mild Decline and Recovery”). Class 1 was associated with higher 30-day ICU mortality (eICU: 46.7%; MIMIC: 24.6%). In doubly robust analyses, the class 2 remained associated with lower ICU mortality in both cohorts, with odds ratios (ORs) of 0.82 (95% CI, 0.72-0.96) in eICU and 0.74 (95% CI, 0.55-0.95) in MIMIC. By Day 30, the trajectory model outperformed SOFA and OASIS, with an AUC of 0.74 versus 0.54 and 0.59, respectively. This trajectory-based classification showed superior prognostic performance for 30-day ICU mortality and highlights the potential value of dynamic monitoring in post-cardiac arrest management.

PMID:42059137 | DOI:10.1177/00469580261448815

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Nevin Manimala Statistics

The Impact of Single Nucleotide Polymorphism Ss52050737 in Luteinizing Hormone/Choriogonadotropin Receptor Gene on Some Reproductive Traits in Friesian Cows

Reprod Domest Anim. 2026 May;61(5):e70212. doi: 10.1111/rda.70212.

ABSTRACT

The luteinizing hormone/choriogonadotropin receptor (LHCGR) gene is potentially a useful genetic marker for cattle reproductive status. This study aimed to investigate the impact of the LHCGR gene’s ss52050737 polymorphism on age at first calving (AFC), calving interval (CI), and ovarian status using the TaqMan PCR assay. AFC was categorized into 25-34 and 35-45 months, while CI was grouped into 330-410 and 411-800 days. Ovarian status was classified as active or inactive ovaries. Blood samples were collected from cows using EDTA-containing vacutainer tubes and stored at -20°C until DNA extraction and analysis. Three genotypes (GG, GT, and TT) were identified for the LHCGR gene SNP (ss52050737). The homozygous GG genotype was more frequent in cows with a CI of 330-410 days, and the genotype distribution showed a statistically significant association (p = 0.018) in cows with CI 330-410 and 411-800 days. On the other hand, the GG genotype was not significantly different in relation to AFC and ovarian status (active or inactive). These findings suggest that the ss52050737 polymorphism of the LHCGR gene has an impact on calving interval, and the G allele is associated with the CI of 330-410 days.

PMID:42059105 | DOI:10.1111/rda.70212

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Prevalence and Predictors of Missed Nursing Care in Greek Public Hospitals: A National Cross-Sectional Study

J Nurs Manag. 2026;2026(1):e3078316. doi: 10.1155/jonm/3078316.

ABSTRACT

AIM: To describe the prevalence of Missed Nursing Care and its predictors in Greek public hospitals.

BACKGROUND: Missed Nursing Care is defined as any aspect of required patient care that is omitted or delayed. Despite the available studies, little is still known in countries with significant nursing shortages, such as Greece, where 2.23 registered and assistant nurses per 1000 population have been reported, significantly below the EU-27 average.

METHODS: A national cross-sectional study was conducted in 28 of 124 public hospitals in Greece. Nurses and nursing assistants working in medical or surgical units, providing direct care to adult patients, and with at least 3 months of experience were eligible. The MISSCARE Survey Part A (5-point Likert scale; 1 = never, 5 = always missed), Part B (reasons, four-point Likert scale; 1 = not significant, 4 = significant reason) and the Practice Environment Scale of the Nurse Work Index (4-point Likert scale; 1 = totally agree, 4 = totally disagree) were used. Descriptive and inferential statistics were applied.

RESULTS: A total of 676 nurses participated. The Missed Nursing Care Part A total score was 2.06 (±0.65), with patients’ daily activities (mean = 2.32 ± 0.73) receiving higher scores than activities related to health status and treatments (mean = 1.80 ± 0.63). The overall score on the Practice Environment Scale of the Nurse Work Index was 2.53 (±0.49). Multiple linear regression analysis showed that issues in nursing care standards for quality of care, staffing adequacy and communication within the team were the most significant predictors of Missed Nursing Care.

CONCLUSION: Missed Nursing Care is a major problem in Greek hospitals. Inadequate staffing is a key factor in missed care according to nurses’ perceptions. Increasing nursing staff, along with implementing standards for nursing care and improving communication among team members, will enhance the quality of health services in Greece.

IMPLICATIONS FOR NURSING MANAGEMENT: Strengthening staffing levels and reinforcing nursing standards are essential strategies for reducing Missed Care in Greek public hospitals.

PMID:42059103 | DOI:10.1155/jonm/3078316

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The Impact of Mushroom Management on Nurses’ Job Satisfaction: The Mediating Role of Organizational Identification

J Nurs Manag. 2026;2026(1):e8888440. doi: 10.1155/jonm/8888440.

ABSTRACT

BACKGROUND: Mushroom management, a leadership style characterized by withholding information, excluding employees from strategic processes, and maintaining top-down control, has been linked to adverse organizational outcomes. However, its impact on nurses and the psychological mechanisms through which this influence operates remain underexamined.

PURPOSE: This study examines the direct and indirect effects of mushroom management on nurses’ job satisfaction, with organizational identification (OI) as the mediating variable, guided by affective events theory and social identity theory.

METHODS: A cross-sectional survey was conducted with 317 nurses employed in private hospitals in Diyarbakır, Türkiye. Data were collected using validated Turkish versions of the Mushroom Management Scale (Birincioğlu and Tekin, 2018), Job Satisfaction Scale (Judge et al., 2008; Keser and Bilir, 2019), and Organizational Identification Scale (Mael, 1988; Tüzün and Özdoğan, 2006). All scales use a five-point Likert format (1 = strongly disagree to 5 = strongly agree). Confirmatory factor analysis confirmed good model fit (χ2/df = 2.21, CFI = 0.95, RMSEA = 0.062). Mediation was tested using Hayes’ PROCESS macro (Model 4) in SPSS 23.0 with 5000 bootstrap samples.

RESULTS: Mushroom management had significant negative effects on OI (standardized β = -0.46, p < 0.001) and job satisfaction (standardized β = -0.21, p = 0.001). OI positively predicted job satisfaction (standardized β = 0.48, p < 0.001). Mediation analysis confirmed a significant indirect effect (standardized β = -0.22, 95% CI [-0.31, -0.14]), with OI accounting for 51% of the total effect indicating partial mediation.

CONCLUSIONS: Mushroom management is associated with lower OI and job satisfaction among nurses, with OI serving as a key identity-based psychological mechanism. Healthcare leaders should prioritize transparent communication, participatory decision-making, and identity-affirming leadership practices to enhance nurse well-being and retention.

IMPLICATIONS FOR NURSING MANAGEMENT: Findings highlight the need for structured information-sharing protocols, mushroom-management-specific leadership training, and shared governance structures in private hospital settings. Periodic organizational climate monitoring using validated instruments is recommended.

PMID:42059094 | DOI:10.1155/jonm/8888440

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Attitudes towards conceptual and philosophical issues in psychiatry and psychiatric education: A survey of US and UK trainees

Australas Psychiatry. 2026 Apr 30:10398562261444981. doi: 10.1177/10398562261444981. Online ahead of print.

ABSTRACT

ObjectivesThis survey evaluated psychiatry trainees’ attitudes toward conceptual and philosophical issues in psychiatry practice, research and training.MethodsA 20-item Likert questionnaire was administered to 156 psychiatry trainees (53 UK, 103 US) via Webropol (UK) and REDCap (US). The survey assessed demographics, familiarity with conceptual and philosophical issues, attitudes toward its importance, confidence in three domains of conceptual competence, and views on specific philosophical issues. Descriptive statistics and Mann-Whitney U tests were used to analyze UK and US responses. Free-text responses provided qualitative data.ResultsMost trainees (82% research, 92% practice) recognized the importance of conceptual and philosophical issues in psychiatry, with 96% supporting their inclusion in training, but only 28% felt their current training had adequately prepared them. Trainees were ‘somewhat confident’ in recognizing conceptual assumptions implicit in psychiatric work but felt less confident that they possessed the requisite philosophical vocabulary and ability to critically evaluate philosophical issues. Regarding specific philosophical positions, responses revealed a strong endorsement of explanatory pluralism and a rejection of naturalist definitions of mental disorder.ConclusionTrainees viewed conceptual skills as important but felt unprepared by current training programs. This article advocates for the integration of ‘conceptual competence’ in psychiatric education.

PMID:42059093 | DOI:10.1177/10398562261444981

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Progress and Gaps: Two Decades of Female Authorship in High-Impact Otolaryngology Journals

Otolaryngol Head Neck Surg. 2026 Apr 30. doi: 10.1002/ohn.70258. Online ahead of print.

ABSTRACT

OBJECTIVE: To evaluate longitudinal trends in female authorship in high-impact otolaryngology journals and assess changes in representation across first and last author positions over a 20-year period.

STUDY DESIGN: Cross-sectional bibliometric analysis.

SETTING: Three high-impact otolaryngology journals: JAMA Otolaryngology-Head & Neck Surgery, The Laryngoscope, and Otolaryngology-Head and Neck Surgery.

METHODS: Research articles published in 2004 and 2024 were identified. First and last author genders were determined using publicly available sources. Descriptive statistics and proportional comparisons were performed to compare gender distribution across authorship positions and time points.

RESULTS: A total of 3733 authors across 1948 original articles were analyzed. Overall female authorship increased from 15.5% in 2004 to 33.5% in 2024 (P < .001). Female first authorship more than doubled from 15.9% to 39.9% (P < .001), while female last authorship rose more modestly from 15.6% to 26.4% (P < .001).

CONCLUSION: Female authorship in otolaryngology has grown substantially over the past 2 decades, reflecting progress in early-career scholarly participation. However, persistent underrepresentation in senior authorship positions highlights enduring barriers to academic advancement. Continued efforts to improve mentorship, sponsorship, and equitable promotion practices are essential to achieving gender equity in otolaryngology scholarship.

PMID:42059091 | DOI:10.1002/ohn.70258

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Family Members’ Experiences Communicating With Coroners in Suspected Hereditary Sudden Cardiac Death Cases: A Mixed Methods Study in Canada

Circ Popul Health Outcomes. 2026 Apr 30:e012967. doi: 10.1161/CIRCOUTCOMES.125.012967. Online ahead of print.

ABSTRACT

BACKGROUND: Sudden cardiac death (SCD) can be caused by heritable cardiac conditions, as such, up to 50% of family members may be at risk. Coroners are responsible for communicating this risk, in addition to investigating the cause of death. The purpose of this study was to explore how family members of SCD victims experience the type, timing, and suitability of communication with coroners about the cause of death and their own risk for SCD.

METHODS: We conducted an explanatory sequential mixed methods study. Eligible family members of SCD victims aged 2 to 70 years, who died in 2021 from a potentially heritable cardiac condition and were investigated by the Office of the Chief Coroner of Ontario (Canada), were invited to complete a web survey or telephone interview. We used descriptive statistics to analyze the survey data and thematic analysis to analyze the interview data. Quantitative and qualitative data integration occurred at multiple levels.

RESULTS: We sent survey invitations to 126 family members of 115 SCD victims; 50 completed the web-based survey between September 2022 and February 2024. We interviewed a subset of 17 participants. Most received initial communication by phone (n=30, 60%) or in-person (n=13, 26%). Although many (n=39; 78%) received a timeline for death investigation results, 16 (32%) did not receive results within the expected timeframe. In interviews, family members described effective communication as clear, with the coroners’ demeanor being important, in particular, perceived as kind, accessible, and approachable. When communication needs went unmet, families relied on external support networks (outside of the coroner system) to fill information gaps. Suggestions for improved communication included repeating information and using multiple communication modes to enhance understanding.

CONCLUSIONS: Findings emphasize the need for coroners to use empathetic approaches and provide timely, clear information. Addressing communication gaps may better meet the needs of grieving SCD families.

PMID:42059081 | DOI:10.1161/CIRCOUTCOMES.125.012967

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Blood Pressure Change and Subclinical Target Organ Damage in Mid-Adulthood

Hypertension. 2026 Apr 30. doi: 10.1161/HYPERTENSIONAHA.125.26364. Online ahead of print.

ABSTRACT

BACKGROUND: Blood pressure (BP) is a dynamic trait associated with cardiovascular disease. We aimed to estimate age-specific BP levels and rates of change from childhood to mid-adulthood and to examine their associations with subsequent subclinical target organ damage.

METHODS: We included 2508 participants from the Hanzhong Adolescent Hypertension Study with BP measured ≥4× from 1987 to 2023. Surrogate markers of target organ damage were assessed, including arterial stiffness, left ventricular hypertrophy, and albuminuria. Growth models were used to construct BP trajectories and estimate age-specific BP levels and rates of change (slopes).

RESULTS: Rates of change in BP at each age point from childhood to mid-adulthood were positively associated with arterial stiffness and albuminuria in mid-adulthood, independent of corresponding BP levels. The magnitude of the associations rose from childhood, peaked in adolescence, and declined thereafter. For example, odds ratios (95% CIs) per 1 SD increase in systolic BP change rates for arterial stiffness increased from 1.94 (1.69-2.24) at age 6 to 2.11 (1.82-2.44) at age 13, then declined to 1.13 (1.01-1.28) by age 52. Faster BP increases were more strongly associated with arterial stiffness and albuminuria than concurrent BP levels during childhood and adolescence, whereas the opposite trend was observed in young and mid-adulthood. Similar age-dependent trends were identified for left ventricular hypertrophy, with minor variations in the ages at which associations reached statistical significance.

CONCLUSIONS: Accelerated BP increases during childhood and adolescence show a stronger association with mid-adult subclinical target organ damage than increases occurring in adulthood.

PMID:42059070 | DOI:10.1161/HYPERTENSIONAHA.125.26364