Tag: nevin manimala

Genet Med. 2025 Nov 11:101635. doi: 10.1016/j.gim.2025.101635. Online ahead of print.

ABSTRACT

PURPOSE: This report analyzes Medical Genetics and Genomics (MGG) training trends from 2015 to 2024. Understanding such trends is vital for developing targeted recruitment and workforce development initiatives.

METHODS: Matriculation data from the American Board of Medical Genetics and Genomics (ABMGG) and publicly available data from the National Resident Matching Program (NRMP) Main Residency and Specialty Matches were reviewed. Descriptive statistics and linear regression analysis were used to compare growth among MGG training pathways and to analyze trends.

RESULTS: From 2015 to 2024, there has been a small, but not statistically significant, increase in the total number of individuals who have matched into categorical MGG, combined Pediatrics (Peds)-MGG, and combined Internal Medicine (IM)-MGG residency programs as a whole. This has been driven by an increase in the number of matches to combined Peds-MGG programs. Matriculation into training programs has exceeded the number of matches in categorical MGG as some positions have been filled outside of the NRMP Match. The average match rate for all applicants in categorical MGG (87%) has been higher than that for Peds-MGG (52%).

CONCLUSION: Growth in applicants to combined programs and matriculation into residency programs after the NRMP Match has been promising; however, these increases are not enough to fulfill growing workforce demands.

PMID:41239884 | DOI:10.1016/j.gim.2025.101635

Health Technol Assess. 2025 Nov;29(60):1-29. doi: 10.3310/ANDK1124.

ABSTRACT

BACKGROUND: Patients with symptoms of pain and restricted function related to knee osteoarthritis are typically offered a knee replacement. However, a proportion remain dissatisfied with their outcomes, and the failure risk is disproportionately higher in the young. Knee joint distraction may be an intervention to postpone the time to knee replacement in this patient population.

OBJECTIVE AND MAIN OUTCOME MEASURE: The primary objective of the Knee Arthroplasty versus Joint Distraction Study for Osteoarthritis (KARDS) was to evaluate the effectiveness of knee joint distraction compared to knee replacement based on patient-reported pain 12 months post surgery using the Knee Injury and Osteoarthritis Outcomes Score pain score as the primary outcome.

DESIGN AND METHODS: KARDS was an open-label, two-arm individually randomised controlled non-inferiority trial with an embedded 12-month internal pilot phase and process evaluation to evaluate recruitment feasibility. A hybrid expertise design was used to account for surgeon expertise and potential lack of individual equipoise. The trial was closed to recruitment early following cessation of elective orthopaedic surgery secondary to COVID-19 pandemic. Descriptive statistics are reported.

SETTING: United Kingdom National Health Service Trusts.

PARTICIPANTS: Adult patients aged < 65 years with symptoms severe enough to warrant knee replacement, in the opinion of the treating clinician.

INTERVENTIONS: Participants were randomised to receive either knee joint distraction (static distraction of 5 mm, using external fixator for 6 weeks) or knee replacement.

RESULTS: Twenty-four participants were randomised from a single centre between March 2021 and October 2022 with minimum 3-month safety follow-up post surgery. Eleven participants were randomised to knee joint distraction and 13 to knee replacement. Seventeen patients were male (71%), median age 60 (47-65) years. One patient withdrew due to being medically unfit for surgery and two received a different treatment than which they were randomised (one crossover from each arm). The median Knee Injury and Osteoarthritis Outcomes Score pain score in the knee joint distraction group improved from 38.9 (22-50) at baseline to 55.6 (0-100) at 12 months, corresponding scores in the knee replacement improved from 30.6 (6-36) to 75.0 (50-100). Adverse events were more common with knee joint distraction, pin site infection being the commonest complications (n = 4, 58%). As part of process evaluation, we conducted semistructured qualitative interviews with staff in secondary care and with study participants. Data were analysed using thematic content analysis. One overarching theme emerged: ‘An unexpected journey’, which encapsulates staff and participants’ experiences.

CONCLUSION: Reduced research capacity and the suspension of elective surgery following the COVID-19 pandemic caused significant recruitment barriers. Despite early termination, KARDS demonstrated that patients were willing to be recruited to a trial investigating a novel treatment for knee osteoarthritis and the trial was feasible and implementable. The limited results indicated that the technique is safe with no safety concerns. Clinical and cost-effectiveness of knee joint distraction remains uncertain. The embedded KARDS process evaluation has provided helpful insights.

LIMITATIONS: Reduced research capacity at sites and suspension of elective surgery services within the United Kingdom following COVID-19 caused significant recruitment barriers to KARDS. All the recruited patients in both arms of the study were White.

FUTURE WORK: As a commissioned piece of research with delivery significantly impacted by the National Health Service environment post-COVID and the impact on National Health Service surgical services, the research question remains highly relevant. Any future research in this field can be helped by the pilot data published here along with the lessons learnt.

FUNDING: This synopsis presents independent research funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme as award number 17/122/06.

PMID:41239860 | DOI:10.3310/ANDK1124

Orthod Craniofac Res. 2025 Nov 15. doi: 10.1111/ocr.70061. Online ahead of print.

ABSTRACT

OBJECTIVE: This study aimed to evaluate the association between upper airway obstruction sites and the morphology of lip and perioral soft tissues in paediatric patients.

MATERIALS AND METHODS: Upper airway obstruction sites were classified into four categories using Fujioka and Baroni’s methodology: nasopharyngeal obstruction (NO), oropharyngeal obstruction (OO), combined nasopharyngeal-oropharyngeal obstruction (NO + OO) and a control group (CG). Primary outcomes focused on quantifying upper and lower lip thickness, while secondary outcomes evaluated perioral soft tissue morphology and maxillary skeletal parameters. Statistical comparisons were performed using one-way ANOVA, Kruskal-Wallis H test and chi-square tests. A multinomial logistic regression (reference = CG) examined adjusted associations, including ANB and SN-MP as covariates.

RESULTS: A total of 256 paediatric patients with pre-treatment lateral cephalograms were included, 64 in each group. Comparative analysis revealed the NO group demonstrated significantly greater upper lip thickness (p < 0.001) and eversion (p = 0.012) compared to the CG. Additionally, the NO group displayed a greater distance between the incisal edge of the lower anterior teeth and the uppermost point of the lower lip than the OO and CG groups. Regression analyses confirmed upper lip thickness was positively associated with all obstruction types, whereas upper lip length was inversely related to NO and NO + OO.

CONCLUSIONS: Nasopharyngeal obstruction was associated with upper lip thickening and eversion, while oropharyngeal obstruction corresponded to lower lip protrusion. These findings suggest that distinct obstruction sites are linked to specific perioral and maxillary morphological patterns, emphasising the importance of airway evaluation in orthodontic diagnosis and treatment planning.

PMID:41239851 | DOI:10.1111/ocr.70061

Int J Gynaecol Obstet. 2025 Nov 15. doi: 10.1002/ijgo.70650. Online ahead of print.

ABSTRACT

OBJECTIVE: This study develops and validates a sex-informed transcriptomic prognostic score derived from sex-stratified survival analyses, with a focus on gynecologic malignancies.

METHODS: This retrospective, computational multi-cohort study analyzed transcriptomic and clinical data from The Cancer Genome Atlas (TCGA; n ≈ 5000) and CPTAC-3 (n = 2191). A 10-gene score was constructed using sex-stratified Cox models and LASSO regression across 20 TCGA tumor types. Prognostic performance was evaluated using hazard ratios and time-dependent AUCs at 1, 3, and 5 years. Analyses followed a four-phase design: discovery in TCGA, internal cross-cancer validation, external validation in independent cohorts (MSK-IMPACT, CPTAC-3, and LIHC-FR), and biological validation using single-cell and spatial transcriptomic data from formalin-fixed paraffin-embedded tissues. Patients were stratified into high- and low-risk groups based on the median gene-expression score, with optimal cutpoints determined using maximally selected rank statistics where indicated. While the discovery analyses were sex-stratified, the final 10-gene score is sex-agnostic and applicable to both sexes.

RESULTS: The score showed strong prognostic discrimination (hazard ratio = 2.15; 95% confidence interval 1.60-2.88; P < 0.001), with areas under the curve ranging from 0.69 to 0.72 across timepoints. It remained robust across datasets and analytic platforms. In gynecologic tumors, high-score regions colocalized with fibroblast-rich, immune-depleted areas, reflecting transcriptional programs of stromal remodeling and immune exclusion linked to immunotherapy resistance.

CONCLUSION: This sex-informed, spatially validated score provides a reproducible and biologically interpretable framework for transcriptomic risk stratification in gynecologic cancers. By capturing immune-evasive and aggressive tumor states, it might inform biomarker-guided clinical trials and support context-appropriate implementation of precision oncology strategies.

PMID:41239842 | DOI:10.1002/ijgo.70650

Psych J. 2025 Nov 15. doi: 10.1002/pchj.70065. Online ahead of print.

ABSTRACT

Facial attractiveness is a critical factor in forming interpersonal impressions. Evaluations of facial attractiveness were previously considered universal. However, it has recently been pointed out that individuals and cultures can diversify their evaluations. This study conducted Web experiments using the facial images of Japanese and American participants to examine the effects of raters’ gender, age, and culture on facial attractiveness. Experiment 1 examined the impact of gender and age on Japanese raters. Experiment 2 explored the effects of culture on Japanese and American raters. Statistical and morphometric analyses were conducted on the obtained data. The results showed significant positive correlations between attractiveness ratings across gender, age, and culture. However, the results of the geometric morphometrics revealed that several differences in preferences regarding facial contours were observed among participants by gender. Additionally, Japanese raters were more likely than American raters to emphasize raised eyebrows for faces in attractive male images, and smaller mouths for faces in attractive female images. These results suggest that the facial features driving attractiveness evaluations differ depending on gender and culture, offering detailed insights into the culturally diverse standards of facial attractiveness. This study adds to the growing understanding of how cultural and individual factors shape aesthetic preferences, questioning the notion of universal beauty, and offering a clearer framework for future cross-cultural research on facial attractiveness.

PMID:41239838 | DOI:10.1002/pchj.70065

Anat Rec (Hoboken). 2025 Nov 15. doi: 10.1002/ar.70079. Online ahead of print.

ABSTRACT

Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce. Here, we present the largest osteopathological survey to date of extant crocodilian skeletal material, comprising 927 individuals and 22,281 skeletal elements spanning all three extant crocodilian families. Our results reveal 1969 osteopathologies from 414 of all individuals (44.7%). Bone trauma is the most prevalent osteopathology, representing 43.9% of all pathologies observed, followed by inflammatory lesions (27.3%) and degenerative joint disorders (11.5%). Statistical analyses demonstrate significant correlations between adult body size, ontogeny, and trauma frequency, with large-sized crocodilian species and older individuals sustaining substantially more injuries. The skull, particularly the dorsal cranial aspect, showed considerably higher involvement of trauma compared to the rest of the skeleton. We also show that non-traumatic pathologies such as inflammation and degenerative joint disorders increase in larger crocodilian species and with ontogeny. These findings underscore the behavioral and physiological drivers of skeletal disease in modern crocodilians and offer key comparative data for interpreting osteopathologies in fossil archosaurs and archosauriforms.

PMID:41239832 | DOI:10.1002/ar.70079

Int J Gynaecol Obstet. 2025 Nov 15. doi: 10.1002/ijgo.70627. Online ahead of print.

ABSTRACT

OBJECTIVE: Primary dysmenorrhea (PD), menstrual pain in the absence of pathology, is the main reason for gynecological consultation in young women. Physical agents, used in physiotherapy for therapeutic purposes, can be self-used by women with primary dysmenorrhea. The objective of this study is to determine the best-known and most used physical agents. The study also investigates pain intensity, perceived pain, and the areas of most frequent painful.

METHODS: An observational, cross-sectional study was carried out. The sample was a cohort of adult female population of students or university researchers from the University of A Coruña (Spain) with primary dysmenorrhea. Data collection instrument was an online self-administered questionnaire. Main variables were pain intensity, description and location (Numeric Rating Scale and McGill Pain Questionnaire, short version), and physical agents used (self-reported). Kendall’s coefficient of concordance, Spearman’s correlation coefficient, the χ²-test, the Mann-Whitney U-test, and the Kruskal-Wallis test were used for statistical analysis.

RESULTS: Among 736 respondents, 216 were considered PD cases. Heat, postures, and massage are the most well-known physical agents (99.07%, 214 women; 85.6%, 185 women; 79.2%, 171 women, respectively). They are also the most used (heat, 92.1%, 199 women; postures, 81.9%, 177 women; 50 massage, 75.5%, 163 women). The abdomen, rachis, and lumbopelvic area were the most common pain perception locations (99%, 214 women).

CONCLUSION: Heat, postures, and massage were the most used, most recommended, and most effective physical agents. Physical exercise was the least known but the fourth most effective and the sixth most widely used physical agent.

IMPACT: This research provides relevant information from which to develop future intervention strategies. Knowing the most painful areas is also relevant to identify anatomical locations that can be the object of therapeutic attention.

PMID:41239826 | DOI:10.1002/ijgo.70627

J Food Sci. 2025 Nov;90(11):e70640. doi: 10.1111/1750-3841.70640.

ABSTRACT

Meat and vegetable processing wastewaters are challenging to treat due to high concentrations of recalcitrant organic compounds-such as fats, oils, and cellulose-that resist conventional degradation. This study systematically evaluated the use of 915 MHz microwave (MW) processing, focusing on the effects of specific energy flux (SEF, in J/kg·s), total solids (TS) concentration, and flow rate on enzymatic activity and physicochemical properties. In vegetable processing wastewater, optimized MW conditions (SEF = 3,244.21 J/kg·s, TS = 2%) maximized cellulase activity (50.09 U/mL) and glucose release (0.1551 mg/mL), whereas higher TS (4%) reduced treatment efficacy. In meat processing wastewater, increased SEF (up to 2,775.51 J/kg·s) enhanced lipase activity (29.88 U/mL, 0.45 mg/mL), reduced viscosity and density, and altered the organic acid profile by increasing propionic acid and decreasing acetic acid. Statistical analysis confirmed SEF as the primary driver of biochemical and thermal changes (R² > 0.89). These results demonstrate that optimized 915 MHz MW processing is a scalable, sustainable, and regulatory-compliant technology for food industry wastewater management. The approach improves enzymatic hydrolysis, biodegradability, and resource recovery, while reducing environmental impact and operational costs. Further research is recommended to validate these findings under full-scale industrial conditions.

PMID:41239817 | DOI:10.1111/1750-3841.70640

Curr Drug Res Rev. 2025;17(3):471-480. doi: 10.2174/0125899775313919240822102906.

ABSTRACT

INTRODUCTION: Breast milk is the preferred source of nutrition for premature infants. Galactagogues are used in initiation, induction, and maintenance of lactation. This study examined the effectiveness of fenugreek on prolactin levels and milk volume (primary outcomes), neonatal weight gain, breastfeeding satisfaction, and side effects (secondary outcomes).

METHODS: This triple-blind randomized controlled trial was conducted on 68 mothers with preterm newborns less than 32 weeks in Al-Zahra and Taleghani hospitals in Tabriz-Iran. Participants were randomly allocated into fenugreek and placebo groups. About 500 mg of fenugreek and placebo capsules were administered to the participants three times a day, from the fifth day after delivery to the 14th day. Breast milk volume was measured on the fourth day after delivery (one day before the intervention), the seventh day, and the fifteenth day after the intervention. Prolactin levels were measured in the morning before and after the intervention.

RESULTS: On the seventh day of the intervention, milk volume was significantly higher in the fenugreek group than in the placebo group (p =0.017). Nevertheless, no statistically significant difference was observed between groups in milk volume (p =0.073) and prolactin level (p =0.324) on day 15. Moreover, no statistically significant difference was observed between groups regarding newborn weight after intervention (p =0.172) or satisfaction with breastfeeding (p =0.484). None of the participants reported any side effects.

CONCLUSIONS: Fenugreek increases milk volume but has no significant effect on prolactin levels. Further trials with larger sample sizes should be performed to obtain conclusive results.

CLINICAL TRIAL REGISTRATION NUMBER: IRCT20120718010324N62.

PMID:41239794 | DOI:10.2174/0125899775313919240822102906

Acta Obstet Gynecol Scand. 2025 Nov 14. doi: 10.1111/aogs.70093. Online ahead of print.

ABSTRACT

INTRODUCTION: Survival and healthcare for patients with congenital heart disease have improved, and the number of pregnancies among women of childbearing age with congenital heart disease has increased. Our aim was to investigate obstetric outcomes in a large retrospective, national registry study of women with congenital heart disease compared to controls.

MATERIAL AND METHODS: The study included women over 18 years of age from the Swedish Registry of Congenital Heart Disease. Each case was matched with 10 controls from Statistics Sweden, based on the mother’s birth year and birth county and all were subsequently linked to the Swedish Medical Birth Register. We included 7998 pregnancies in women with congenital heart disease and 84 799 in controls during 1973-2020.

RESULTS: The mean age at delivery for women with congenital heart disease and controls was 28.7 (±5.0) and 28.7 (±5.1) years, respectively. Women with congenital heart disease smoked less, had a shorter gestation and a higher incidence of delivery by Cesarean section compared to controls. The likelihood of Cesarean section was increased in women with congenital heart disease compared to controls: odds ratio 1.45 (95% confidence interval (CI) 1.37-1.54). Compared to controls, women with congenital heart disease had an increased likelihood of giving birth to small-for-gestational-age neonates: odds ratio 1.40 (95% CI 1.23-1.58). The association regarding small-for-gestational-age remained after adjusting for body mass index, age, smoking, comorbid diseases and preeclampsia. Women with congenital heart disease had an increased likelihood of prematurity compared to controls: odds ratio 1.47 (95% CI 1.35-1.59). The likelihood of Cesarean section, small-for-gestational-age neonates and prematurity was higher in women with severe congenital heart disease than mild/moderate congenital heart disease, both compared to controls.

CONCLUSIONS: In this large national case-control study in women with congenital heart disease, we showed an increased likelihood of giving birth prematurely by Cesarean section, and having a small-for-gestational-age neonate compared to matched controls. The likelihood seems even higher in women with severe congenital heart disease. Further research is needed to explore the underlying reasons for the high rates of Cesarean section in women with congenital heart disease.

PMID:41239781 | DOI:10.1111/aogs.70093