Tag: nevin manimala

Endocr Connect. 2022 Oct 1:EC-22-0325. doi: 10.1530/EC-22-0325. Online ahead of print.

ABSTRACT

We assessed the prevalence of two novel islet autoantibodies, those targeting ubiquitin-conjugating enzyme 2L3 (UBE2L3) and eukaryote translation elongation factor 1 α1 (eEF1A1), in type 1 diabetes mellitus (T1DM) to evaluate their utility in T1DM diagonsis with comparison to other islet autoantibodies. We also aimed to determined whether age and ethnicity impacted their diagnostic value. Electrochemiluminescence (ECL) assay was used to detect UBE2L3-Ab and eEF1A1-Ab in 193 Chinese Han and 570 American Caucasian subjects with T1DM, 282 Chinese Han and 199 American Caucasian controls. In Chinese and American cohorts, the UBE2L3-Ab cut-off indices were 0.039 and 0.038, and the eEF1A1-Ab cut-off indices were 0.048 and 0.050, respectively. The prevalence of UBE2L3-Ab was significantly higher in the Chinese (9.33%) and American(3.86%) subjects with T1DM than in the controls (p<0.05). The prevalence of UBE2L3-Ab in T1DM were significantly higher in Chinese than in American (p<0.05). Albeit not statistically significant, the prevalence of UBE2L3-Ab in T1DM was slightly higher in children than in adults in both ethnicity. The differences in eEF1A1-Ab levels between subjects with T1DM and controls was not significant. Meanwhile, all American subjects with UBE2L3-Ab also harbored GADA or IAA. In contrast, 2.07% of the Chinese subjects with UBE2L3-Ab positive were previously classified as autoantibody-negative based on GADA and IAA. So the prevalence of UBE2L3-Ab in T1DM patients was significantly higher than in controls and was variable according to ethnicity as well as tend to be higher in children than adults. However, UBE2L3-Ab and eEF1A1-Ab may not reliable diagnostic biomarker for T1DM.

PMID:36279111 | DOI:10.1530/EC-22-0325

J Gastrointest Surg. 2022 Oct 24. doi: 10.1007/s11605-022-05495-7. Online ahead of print.

ABSTRACT

BACKGROUND: Evidence for adjuvant chemotherapy in gallbladder cancer (GBC) is conflicting, with a postulated beneficial effect reported in T2 stage or higher, and node-positive tumours. This study aims to assess the survival benefit of peri-operative chemotherapy in stage II (pT2N0) GBCs.

METHODS: A retrospective analysis of stage II GBCs who underwent curative surgical resection was done. Patients receiving neo-adjuvant therapy (NACT) prior to resection of the gallbladder primary were excluded. Primary endpoint was disease-free survival, and outcomes of patients who received chemotherapy were compared to those who did not. Survival curves were plotted using a Kaplan-Meier analysis and difference between the survival curves was analysed using a log-rank test.

RESULTS: Two hundred seventy-six patients of stage II GBC were included, of whom 188 (68.1%) received chemotherapy and 88 (31.8%) did not. Forty-one (21.8%) patients received chemotherapy in the neo-adjuvant setting. There was no significant difference in the survival of patients who did and did not receive chemotherapy (5-year DFS 67.8% vs 66%, p = 0.795). There was no significant difference in the survival of patients who received chemotherapy in the adjuvant or neo-adjuvant setting (5-year DFS 66.4% vs 71.8%, p = 0.541). There was no statistically significant difference in the survival of patients with high-risk histologic features and who did and did not receive chemotherapy (3-year DFS 72.4% vs 56%; p = 0.379).

CONCLUSIONS: Routine use of chemotherapy, either in the adjuvant or neo-adjuvant setting, offers no survival advantage in stage II (pT2N0) gallbladder cancers.

PMID:36279092 | DOI:10.1007/s11605-022-05495-7

Clin Rheumatol. 2022 Oct 24. doi: 10.1007/s10067-022-06417-3. Online ahead of print.

ABSTRACT

OBJECTIVE: To compare the effects of telerehabilitation vs home-based exercise programs for knee osteoarthritis (KOA).

METHOD: Patients diagnosed with moderate/mild KOA were enrolled in the study and randomized into two groups. The patients in the telerehabilitation group did their exercises via video conference simultaneously, accompanied by a physiotherapist, while the patients in the control group were given a brochure showing how to do the exercises and explaining how to do each exercise. Patients completed 30-s chair stand test (30 CST), Knee Injury and Osteoarthritis Outcome Score (KOOS), Numeric Rating Scale (NRS), International Physical Activity Questionnaire Short Form (IPAQ-SF), Hospital Anxiety and Depression Scale (HADS), TAMPA Kinesiophobia Scale (TKS), Fatigue Severity Scale (FSS) twice before and after 8-week treatment, and Quality Indicators Questionnaire for Physiotherapy Management of Hip and Knee Osteoarthritis (QUIPA) and Exercise Adherence Rating Scale (EARS) after treatment only. Moreover, the number of painkillers that patients used in the last 15 days was recorded before and after treatment, and patient satisfaction with treatment was questioned after treatment.

RESULTS: Forty-eight patients were included in the study. The mean age of patients was 55.83 ± 6.93 years, and 43 (89.6%) patients were women. No significant differences were determined between groups in terms of baseline characteristics. After the 8-week follow-up, telerehabilitation group demonstrated better 30 CST, IPAQ-SF, KOOS, QUIPA, treatment satisfaction, and total and C subscale of EARS scores increment and greater NRS, HADS, TKS, and FSS score reduction than the control group. It was determined that there was a statistically significant difference between the telerehabilitation and control groups for all of the specified parameters; however, no statistically significant difference was found for the B subscale of EARS.

CONCLUSION: This study indicated that telerehabilitation is superior to self-management. Moreover, through this innovative and population specific web-based approach for KOA, a vast number of patients who have internet access could be reached. Thus, patients with KOA received effective treatment.

PMID:36279075 | DOI:10.1007/s10067-022-06417-3

Environ Sci Pollut Res Int. 2022 Oct 24. doi: 10.1007/s11356-022-23586-5. Online ahead of print.

ABSTRACT

The energy economics literature lacks a consensus on the short- and long-term linkages along with the Granger causality direction between economic growth and energy consumption. This paper examines the relationships between economic growth, fossil fuel and renewable energy consumption, CO₂ emissions, temperature, and population in 56 countries from 1990 to 2019. We contribute to the literature by uniquely grouping countries by climate zone (i.e., tropical, arid, temperate, and continental) following the Köppen-Geiger climate classification approach and employing a panel structural vector autoregressive model (P-SVAR) to study these relationships. In addition, rather than mistakenly using a single energy consumption variable, we divide it into two categories: fossil fuel and renewable energy consumption. Our findings indicate that temperature change has the most negligible impact on economic growth, while CO₂ and renewable energy have the two most significant effects. Our Granger causality tests support all four hypotheses (growth, feedback, conservative, and neutral) that describe the relationship between economic performance and energy consumption, indicating the level of difficulty in recommending an overarching energy policy worldwide. We find that conservative energy consumption and clean energy policies that avoid CO₂ emissions may benefit the selected countries’ economic prosperities.

PMID:36279061 | DOI:10.1007/s11356-022-23586-5

Environ Sci Pollut Res Int. 2022 Oct 24. doi: 10.1007/s11356-022-23732-z. Online ahead of print.

ABSTRACT

To assess the status of hotspots and research trends on geographic information system (GIS)-based landslide susceptibility (LS), we analysed 1142 articles from the Thomas Reuters Web of Science Core Collection database published during 2001-2020 by combining bibliometric and content analysis. The paper number, authors, institutions, corporations, publication sources, citations, and keywords are noted as sub/categories for the bibliometric analysis. Thematic LS data, including the study site, landslide inventory, conditioning factors, mapping unit, susceptibility models, and mode fit/prediction performance evaluation, are presented in the content analysis. Then, we reveal the advantages and limitations of the common approaches used in thematic LS data and summarise the development trends. The results indicate that the distribution of articles shows clear clusters of authors, institutions, and countries with high academic activity. The application of remote sensing technology for interpreting landslides provides a more convenient and efficient landslide inventory. In the landslide inventory, most of the sample strategies representing the landslides are point and polygon, and the most frequently used sample subdividing strategy is random sampling. The scale effects, lack of geographic consistency, and no standard are key problems in landslide conditioning factors. Feature selection is used to choose the factors that can improve the model’s accuracy. With advances in computing technology and artificial intelligence, LS models are changing from simple qualitative and statistical models to complex machine learning and hybrid models. Finally, five future research opportunities are revealed. This study will help investigators clarify the status of LS research and provide guidance for future research.

PMID:36279056 | DOI:10.1007/s11356-022-23732-z

Obes Surg. 2022 Oct 24. doi: 10.1007/s11695-022-06330-3. Online ahead of print.

ABSTRACT

BACKGROUND: Single-nucleotide polymorphisms (SNPs) associated with obesity predict laparoscopic Roux-en-Y gastric bypass (LRYGB) and biliopancreatic diversion with duodenal switch (BPD/DS) for weight loss with good efficiency. However, prediction of weight loss after laparoscopic sleeve gastrectomy using SNPs has not been well investigated.

OBJECTIVES: To predict weight loss after laparoscopic sleeve gastrectomy using obesity-related SNPs and clinical variants in Chinese patients with body mass index (BMI) ≥ 32.5 kg/m².

METHODS: We detected 29 SNPs. Binary logistic regression was used to screen SNPs and clinical variables with predictive value. Receiver operating characteristic (ROC) curves were plotted for clinical variables, SNPs, and their combination, and areas under the ROC curve (AUC) were compared. Internal and external validation tests were performed.

RESULTS: rs12535708, rs651821, and rs5082 were constructed as the genetic risk score (GRS). Preoperative BMI was constructed as the clinical risk score (CRS). Preoperative BMI and SNPs were constructed as the cumulative genetic risk score (CGRS). ROC curves of GRS, CRS, and CGRS showed that the optimal cutoffs were 0.831 (AUC = 0.840; sensitivity, 92.96%; specificity, 64.29%), 43.46 kg/m² (AUC = 0.830; sensitivity, 76.06%; specificity, 85.71%), and 0.921 (AUC = 0.931; sensitivity, 77.46%; specificity, 92.86%), respectively. The AUC of CGRS was significantly greater than that of CRS (P < 0.05) and greater than GRS without statistical significance.

CONCLUSION: In Chinese patients with BMI ≥ 32.5 kg/m², GRS and CRS could predict weight loss success. However, CGRS was superior to GRS or CRS alone.

PMID:36279045 | DOI:10.1007/s11695-022-06330-3

Ir J Med Sci. 2022 Oct 24. doi: 10.1007/s11845-022-03199-0. Online ahead of print.

ABSTRACT

BACKGROUND: Hyponatremia is the most common electrolyte disorder in lung cancer, and it particularly occurs in small cell lung cancer (SCLC) patients. The prognostic significance of hyponatremia has been reported in several studies with controversial results.

AIMS: We aimed in this study to investigate hyponatremia and evaluate its prognostic value in SCLC patients.

METHODS: The data of 373 SCLC patients were analyzed retrospectively. Serum sodium concentrations were measured from blood samples taken from all patients before treatment. Hyponatremia was defined as a serum sodium concentration below 135 mmol/L and then assigned into two groups: mild (130 to 134 mmol/L) and severe (below ≤ 129 mmol/L) hyponatremia.

RESULTS: Hyponatremia was detected in 85 (22.8%) patients (mild hyponatremia in 51 (13.7%) and severe hyponatremia in 34 (9.1%) patients). Furthermore, 26% (63 of 242) of ED-SCLC patients and 16.8% (22 of 131) of LD-SCLC patients had hyponatremia. While no clinical parameter was statistically associated with serum sodium concentrations in LD-SCLC patients, hyponatremic ED-SCLC patients were more frequently associated with weight loss (p = 0.04) and liver metastasis (p = 0.04). In LD-SCLC, the overall survival (OS) rates of patients with hyponatremia were similar to those with normonatremia (p = 0.6). Likewise, hyponatremic and normonatremic ED-SCLC patients had similar life expectancies (p = 0.1). Moreover, the severity of hyponatremia did not affect OS in either LD-SCLC (p = 0.3) or ED-SCLC (p = 0.1).

CONCLUSION: Serum sodium concentration did not have an impact on survival in SCLC patients; thus, we concluded that neither the presence nor the severity of hyponatremia affected the outcome of these patients.

PMID:36279041 | DOI:10.1007/s11845-022-03199-0

Infection. 2022 Oct 24. doi: 10.1007/s15010-022-01931-7. Online ahead of print.

ABSTRACT

PURPOSE: We hypothesized that SARS-CoV-2 infection numbers reported by governmental institutions are underestimated due to high dark figures as only results from polymerase chain reaction (PCR) tests are incorporated in governmental statistics and testing capacities were further restricted as of July, 2022.

METHODS: A point prevalence investigation was piloted by rapid antigen testing (RAT) among participants of the VACCELERATE volunteer registry. 2400 volunteers were contacted, of which 500 received a RAT including instructions for self-testing in the first week of July, 2022. Results were self-reported via e-mail.

RESULTS: 419 valid RAT results were collected until July 7th, 2022. Between July-1 and July-7, 2022, 7/419 (1.67%) tests were positive. Compared to reports of the German Federal Government, our results suggest a more than twofold higher prevalence. Three out of seven positive individuals did not have a PCR test and are therefore likely not to be displayed in governmental statistics.

CONCLUSION: Our findings imply that the actual prevalence of SARS-CoV-2 may be higher than detected by current surveillance systems, so that current pandemic surveillance and testing strategies may be adapted.

PMID:36279033 | DOI:10.1007/s15010-022-01931-7

Environ Monit Assess. 2022 Oct 24;195(1):24. doi: 10.1007/s10661-022-10605-8.

ABSTRACT

This paper analyses data by summarising the concentration values of ground-level ozone (GLO). The study area is situated in central Slovakia and is part of the Western Carpathians. These measurements were carried out between 2015 and 2020, implementing Werner’s method working with passive samplers. The highest average and the highest absolute GLO deposition values were 30.93 ppb and 61.06 ppb, respectively, recorded in August 2015 in the forest in the Kremnické vrchy Mts. The lowest average GLO value in the whole measuring period was 17.72 ppb, measured in the town of Zvolen; the absolute minimum was 4.43 ppb, recorded in April 2016 on an open plot in the Kremnické vrchy Mts. The GLO formation over the study area has not yet reached a steady rate. Since 2007, the developmental trend has been increasing. Statistically significant differences in GLO concentrations were confirmed between the localities with different airborne pollutions. However, the analysis of the existing ozone concentration values showed considerable differences, especially related to the time pattern. The spatial variability was equalised. The extreme values, while remarkable, were dangerous, especially in the forest stands in the Kremnické vrchy Mts., where they were 14 times above the critical level of 32.5 ppb O₃. The dominant factor influencing the GLO concentration was global radiation. The effects of average temperature and rainfall total were less important.

PMID:36279021 | DOI:10.1007/s10661-022-10605-8

Basic Res Cardiol. 2022 Oct 24;117(1):52. doi: 10.1007/s00395-022-00961-4.

ABSTRACT

Ischemic stroke imparts elevated risk of heart failure though the underlying mechanisms remain poorly described. We aimed to characterize the influence of cerebral ischemic injury on cardiac function using multimodality molecular imaging to investigate brain and cardiac morphology and tissue inflammation in two mouse models of variable stroke severity. Transient middle cerebral artery occlusion (MCAo) generated extensive stroke damage (56.31 ± 40.39 mm³). Positron emission tomography imaging of inflammation targeting the mitochondrial translocator protein (TSPO) revealed localized neuroinflammation at 7 days after stroke compared to sham (3.8 ± 0.8 vs 2.6 ± 0.7 %ID/g max, p < 0.001). By contrast, parenchyma topical application of vasoconstrictor endothelin-1 did not generate significant stroke damage or neuroinflammatory cell activity. MCAo evoked a modest reduction in left ventricle ejection fraction at both 1 weeks and 3 weeks after stroke (LVEF at 3 weeks: 54.3 ± 5.7 vs 66.1 ± 3.5%, p < 0.001). This contractile impairment was paralleled by elevated cardiac TSPO PET signal compared to sham (8.6 ± 2.4 vs 5.8 ± 0.7%ID/g, p = 0.022), but was independent of leukocyte infiltration defined by flow cytometry. Stroke size correlated with severity of cardiac dysfunction (r = 0.590, p = 0.008). Statistical parametric mapping identified a direct association between neuroinflammation at 7 days in a cluster of voxels including the insular cortex and reduced ejection fraction (ρ = – 0.396, p = 0.027). Suppression of microglia led to lower TSPO signal at 7 days which correlated with spared late cardiac function after MCAo (r = – 0.759, p = 0.029). Regional neuroinflammation early after cerebral ischemia influences subsequent cardiac dysfunction. Total body TSPO PET enables monitoring of neuroinflammation, providing insights into brain-heart inter-organ communication and may guide therapeutic intervention to spare cardiac function post-stroke.

PMID:36279013 | DOI:10.1007/s00395-022-00961-4