Tag: nevin manimala

Eur J Epidemiol. 2026 Apr 9. doi: 10.1007/s10654-026-01393-3. Online ahead of print.

ABSTRACT

Our study aimed to assess potential associations between food colouring additives and cancer incidence in the French NutriNet-Santé cohort. A total of 105,260 adults (78.3% females; mean age 42.0 ± 14.5y) without prevalent cancer and who completed ≥ 2 24-hour dietary records at baseline were followed for > 7 years. Dietary intakes were assessed using repeated brand-specific 24 h records, and cumulative time-dependent exposure to food additives was evaluated through multiple composition databases and ad-hoc laboratory assays in food matrices. Associations between exposures to food colouring additives (sex-specific tertiles if proportion of exposed participants > 2/3, or non-exposed/lower/higher exposed based on sex-specific median otherwise) and cancer incidence were assessed using multivariable Cox models. We identified 4,226 incident cancer cases (508 prostate, 1,208 breast [387 premenopausal and 821 postmenopausal], and 352 colorectal). Total food colouring additives were associated with higher overall [HR_{higher versus non/lower consumers} (95%CI): 1.14 (1.05-1.24); absolute risk at age 60: 13.3% (higher consumers) vs. 12.1% (lower/non-consumers)], breast [1.21 (1.03-1.42); 5.7%, 4.8%], and postmenopausal breast [1.32 (1.09-1.61); 14.9%, 12.5%] cancer incidence. After False Discovery Rate correction, only plain caramel (European code: E150a) was associated with overall cancer [1.15 (1.07-1.25); 14.0%, 12.1%] and beta-carotene (E160a) with overall [1.16 (1.07-1.25); 13.7%, 11.9%] and breast cancer [1.41 (1.23-1.62); 6.2%, 4.4%]. This study provides novel exploratory evidence linking colouring additives to cancer incidence. Further research is needed to elucidate underlying mechanisms. Findings support recommendations to limit exposure to non-essential food additives (i.e. used primarily for sensory or aesthetic purposes rather than for food safety or preservation) and inform regulatory reassessment.

PMID:41954817 | DOI:10.1007/s10654-026-01393-3

Clin Neuroradiol. 2026 Apr 9. doi: 10.1007/s00062-026-01645-5. Online ahead of print.

ABSTRACT

PURPOSE: Evaluation of the impact of Deep Learning Image Reconstruction (DLIR) compared to Adaptive Statistical Iterative Reconstruction-Veo (ASIR-V) on image quality and early ischemic changes detection on non-contrast computed tomography (NCCT) in stroke suspected patients. A secondary objective was to determine the potential influence of reconstruction algorithm on ASPECT scoring relative to automated e-ASPECT score.

METHODS: Consecutive patients undergoing NCCT within 6 hours of symptom onset were retrospectively included. Images were reconstructed using ASIR-V and high-strength DLIR. Four readers with varying experience independently assessed subjective image quality, gray-white matter differentiation, diagnostic confidence, presence of ischemic lesions and ASPECTS scoring. Diagnostic performance (accuracy, sensitivity, specificity) was calculated using e-ASPECTS as reference. Evaluation time was recorded.

RESULTS: DLIR significantly improved subjective image quality and gray-white matter contrast compared with ASIR-V (odds ratios 2.96-3.96; p 0.001). Diagnostic performance for detecting early ischemic changes showed no significant difference, with similar accuracy, sensitivity and specificity. Evaluation time did not differ. A trend toward higher specificity and reduced bias for ASPECTS ≥6 was observed with DLIR, but mixed-model analysis did not confirm statistical significance.

CONCLUSION: DLIR improves subjective image quality in acute stroke NCCT but does not significantly improve detection accuracy or ASPECTS scoring compared with ASIR-V. A tendency toward improved specificity was observed; further studies with larger cohorts are needed.

PMID:41954793 | DOI:10.1007/s00062-026-01645-5

J Psycholinguist Res. 2026 Apr 9;55(3):52. doi: 10.1007/s10936-026-10241-0.

ABSTRACT

Most psycholinguistic research on action naming has relied on static pictures, even though actions are by nature dynamic events. To overcome this limitation, the present study introduces the first open-access video database developed for French speakers of Quebec, Canada. The corpus includes 136 short video clips depicting everyday actions. Each video was normed for five psycholinguistic variables: name agreement (NA), entropy (H-statistic), response latency, uniqueness naming point-the moment at which an action becomes unambiguously identifiable-and adjusted response latency. Data were collected from 93 native French speakers of Quebec. Most actions elicited consistent name agreement (mean NA = 80.73%), while the mean entropy value (H-statistic = 0.84) reflected the lexical diversity typical of Quebec French. This freely available video-based normative resource offers a dynamic, culturally adapted tool for studying verb processing and supports both clinical applications and experimental investigations in psycholinguistics.

PMID:41954785 | DOI:10.1007/s10936-026-10241-0

Arch Gynecol Obstet. 2026 Apr 9;313(1):159. doi: 10.1007/s00404-026-08414-2.

ABSTRACT

PURPOSE: Studies on vaginal natural orifice transluminal endoscopic surgery (vNOTES), which provides enhanced endoscopic vision via the vaginal route, are limited. Therefore, this study aimed to evaluate the feasibility, safety, and perioperative outcomes of vNOTES hysterectomy in symptomatic patients with giant polymyomatous uteri and no prior vaginal delivery.

METHODS: A prospective single-centre case series was conducted between July 2023 and July 2025. Patients with symptomatic uterine myomatosis and a uterine size equivalent to a gestational age of ≥ 20 weeks with no prior vaginal deliveries were included. The operation time, preoperative and postoperative haemoglobin levels, uterine weight, complications, and length of hospital stay were analysed.

RESULTS: Forty patients met the inclusion criteria. The mean operative time was 95 ± 28 min. The mean preoperative haemoglobin concentration was 11.8 ± 1.2 g/dL, whereas it was 10.9 ± 1.1 g/dL postoperatively. The mean uterine weight was 1,012 ± 312 g. The complication rate was 8%. The major complication rate was 4%. No procedures were converted to laparotomy. The median hospitalisation duration was 23.1 h.

CONCLUSION: vNOTES hysterectomy appears to be a feasible minimally invasive approach for giant polymyomatous uteri in patients with no prior vaginal deliveries, with favourable perioperative outcomes in this prospective case series.

PMID:41954781 | DOI:10.1007/s00404-026-08414-2

Environ Manage. 2026 Apr 9;76(5):141. doi: 10.1007/s00267-026-02431-2.

ABSTRACT

The Big Sandy River Basin (BSRB), which comprises the majority of the surface-mined and reclaimed areas, is a key restoration landscape in Eastern Kentucky. BSRB has a long history of coal mining, followed by various policies adopted to restore the post-mining ecosystems. Kentucky designates priority watersheds (PWs) within major river basins to address environmental issues and direct resources for focused implementation through coordinated efforts. However, clear watershed-scale evidence evaluating ecosystem service (ES) patterns in relation to these policy designations remains limited. Therefore, we conducted spatial and temporal mapping of carbon storage (CS) and sequestration (CSE) from 2001 to 2021 across selected PWs and NPWs, utilizing the National Land Cover Dataset (NLCD) and the InVEST model. The results revealed only a modest net increase in CS in both PWs (+0.93%) and NPWs (+0.16%) from 2001 to 2021. However, CSE patterns exhibited a trajectory towards recovery. Both PWs and NPWs experienced carbon loss during 2006-2011 and followed a gain afterwards until 2021. Between 2001 and 2021, CSE values were nearly 6.5 times higher in PWs (2.27 Mg C/ha) than in NPWs (0.35 Mg C/ha). The economic valuation (EV) of the CS revealed that the landscape offers climate-regulating ES worth more than 6100 USD/ha across years. This study utilized spatial statistics (Moran’s I test) that identified regions with high-high value and low-low value clusters and outliers of CSE across time. These findings support prioritization and monitoring in post-mining watersheds and provide an assessment framework for linking LULCC, ES, and watershed-level policy focus.

PMID:41954775 | DOI:10.1007/s00267-026-02431-2

Telemed J E Health. 2026 Apr 9:15305627261440757. doi: 10.1177/15305627261440757. Online ahead of print.

ABSTRACT

INTRODUCTION: Telemedicine has become an essential tool for providing health care to offshore workers. Despite its advancements, there is still a lack of understanding about its optimal use and the factors affecting it among health care providers in offshore settings. The objective of this work was to study and determine the level of telemedicine utilization among offshore health care workers and its associated factors in Malaysia.

METHODS: In this cross-sectional study, online questionnaires were distributed to health care workers involved in offshore medical services. The questionnaire includes sociodemographic information and the validated Malay version of the Telemedicine Acceptance Model (TAM) Questionnaire. A total of 73 offshore health care workers were recruited from a local company using universal sampling. Data analysis involved descriptive statistics as well as simple and multiple logistic regression.

RESULTS: A total of 65.8% of offshore health care workers reported using telemedicine in their practice. Multiple logistic regression analysis indicated that Chinese and Indian workers were significantly more likely to use telemedicine compared with Malay workers, with adjusted odds ratios of 32.11 (p = 0.045) and 33.51 (p = 0.037), respectively. Workers with a good attitude toward telemedicine had 11.84 times higher odds of utilization (p = 0.004), while those with high behavioral intention were 25.80 times more likely to use telemedicine compared with their counterparts with low behavioral intention (p < 0.001).

CONCLUSIONS: A majority of offshore health care workers utilize telemedicine, with Chinese and Indian ethnicity, good attitude, and high behavioral intention significantly predicting its utilization.

PMID:41954045 | DOI:10.1177/15305627261440757

Diagn Cytopathol. 2026 Apr 9. doi: 10.1002/dc.70122. Online ahead of print.

ABSTRACT

The National Comprehensive Cancer Network (NCCN) guidelines recommend routine, broad-panel based next-generation sequencing (NGS) testing for non-small cell lung carcinomas (NSCLCs) to guide targeted therapies. While cell blocks are the most commonly used cytology specimens, the NCCN advises using non-formalin-fixed, paraffin-embedded (FFPE) specimens when possible. Fine needle aspiration (FNA) cytology smears offer high-quality DNA from intact nuclei without formalin fixation, allow faster processing than cell blocks, and may reduce NGS turnaround time. In this study, we evaluated the utility of smears for molecular analysis in lung adenocarcinomas. We tested 28 smears using the Oncomine Focus Hotspot (OFA) NGS assay and compared NGS quality metrics with paired FFPE specimens (including cell blocks and/or other paired surgical pathology specimens). NGS was successful in 22 of 28 cases with 100% concordance in variant detection between smears and FFPE specimens. The average DNA yield from smears was lower than FFPE, but the difference was not statistically significant. All quality metrics from smears exceeded NGS assay thresholds, with significantly higher percent mapped reads, uniformity and percent on-target compared to FFPE. Thus, despite lower DNA yield, direct smears are excellent alternatives to FFPE specimens for NGS testing in NSCLC.

PMID:41954035 | DOI:10.1002/dc.70122

Eur J Neurol. 2026 Apr;33(4):e70598. doi: 10.1111/ene.70598.

ABSTRACT

BACKGROUND: The worsening of headaches or the occurrence of new headaches can occur after coil embolization. Although the frequency of headaches is reported to be greater when a stent is used, this phenomenon is poorly understood. Therefore, we aimed to evaluate the incidence and intensity of headache in patients treated with non-stent-assisted coil embolization (NSCE) versus stent-assisted coil embolization (SACE) for unruptured intracranial aneurysms (UIAs).

METHODS: In this prospective comparative cohort study, a total of 186 patients treated with coil embolization for UIAs between June 2018 and March 2022 were classified into NSCE or SACE groups. A Cox proportional hazards model was used to identify risk factors for occurrence of headache, and changes in headache intensity over time were assessed using a linear mixed-effects model.

RESULTS: Headaches occurred in 71.0% (132/186) of patients after coil embolization. During the 3-month follow-up, headaches after coil embolization were more common in patients who underwent SACE (adjusted hazard ratio, 1.57; p = 0.02). Female sex, cilostazol medication use, and pre-existing headache were also independently associated with the occurrence of headache after coil embolization. Changes in numeric rating scale (NRS) scores according to stent placement status and trends in NRS scores over time based on stent placement status were not statistically significant.

CONCLUSIONS: Patients treated with SACE were more likely to experience headache after coil embolization than those treated with NSCE were. However, changes in headache intensity over time were not significantly different between the groups.

PMID:41954024 | DOI:10.1111/ene.70598

Stroke. 2026 Apr 9. doi: 10.1161/STROKEAHA.125.054791. Online ahead of print.

ABSTRACT

BACKGROUND: Tenecteplase improves reperfusion and functional outcomes compared with alteplase in patients with large vessel occlusion. We assessed whether this superiority varies with thrombolysis-to-puncture time (TTP).

METHODS: This retrospective analysis of a prospective multicenter cohort included patients with large vessel occlusion who received bridging therapy with either tenecteplase or alteplase between January 2022 and September 2025. Patients were stratified by TTP (<60 versus ≥60 minutes). We subsequently assessed the association of TTP with efficacy and safety outcomes between the alteplase and tenecteplase groups using multivariable logistic regression adjusted for age, baseline National Institutes of Health Stroke Scale score, and time from stroke onset to arterial puncture. Functional independence was defined as a modified Rankin Scale score of 0 to 2 at 3 months.

RESULTS: Of 1106 patients who received bridging therapy, 1003 were included in the primary analysis (tenecteplase, 488; alteplase, 515). The median age was 68 (interquartile range, 58-75) years in both groups, with males comprising 64.3% and 66.0%, respectively. Tenecteplase was associated with superior 3-month functional independence compared with alteplase (53.6% versus 48.1%; adjusted odds ratio, 1.37 [95% CI, 1.03-1.82]). This benefit was concentrated in patients with a TTP <60 minutes, where tenecteplase yielded higher rates of both early recanalization (19.0% versus 9.1%; adjusted odds ratio, 2.36 [95% CI, 1.32-4.23]; P_interaction=0.047) and functional independence (61.0% versus 49.0%; adjusted odds ratio, 1.77 [95% CI, 1.13-2.77]; P_interaction=0.111). No between-agent differences were significant with TTP ≥60 minutes. Safety outcomes were comparable, but each 30-minute TTP increase independently elevated hemorrhagic risks for both agents.

CONCLUSIONS: The recanalization superiority of tenecteplase over alteplase is time-dependent, evident only within a TTP <60 minutes. Although the translation of this advantage into functional outcome was not statistically modified by time, optimizing workflow to achieve this rapid window maximizes the potential benefit of tenecteplase, which should be prioritized in capable settings.

PMID:41953987 | DOI:10.1161/STROKEAHA.125.054791

J Clin Periodontol. 2026 Apr 9. doi: 10.1111/jcpe.70127. Online ahead of print.

ABSTRACT

AIM: To assess how suture diameter, material composition and tissue characteristics influence the tension-to-tearing behaviour of oral soft tissues, with the objective of optimising atraumatic suturing.

MATERIALS AND METHODS: This in vitro cadaver study evaluated 288 standardised porcine oral soft-tissue specimens (144 gingiva, 144 lining mucosa). Twelve different suture types including four distinct diameters (4-0, 5-0, 6-0, 7-0) and three different materials (polyvinylidene fluoride [PVF], polyamide [PA] and polyglycolic acid [PGA]) were tested using a calibrated Instron microtester. Maximum rupture force (N), failure mode and tissue thickness (mm) were recorded. Statistical analysis relied on three-way ANOVA, Tukey’s post hoc testing and Pearson’s correlation (α = 0.05).

RESULTS: The overall mean maximum rupture force was 5.03 ± 3.00 N. Rupture force increased with suture diameter (p = 0.0001) and differed between materials (p < 0.0001; PGA ≈ PVF > PA). Gingival specimens resisted higher loads than mucosal specimens (p = 0.003). Fine sutures (6-0, 7-0) failed mainly by thread rupture, while thicker sutures (4-0, 5-0) caused tissue tearing, supporting the concept of a mechanical safety buffer. PA (6-0) generally preserved tissue integrity, whereas PVF and PGA required 7-0 in delicate mucosa to ensure comparable tissue protection. Tissue thickness correlated positively with rupture force (r = 0.49, p < 0.001).

CONCLUSIONS: Finer sutures (6-0 and 7-0) function as protective mechanical fuses, safeguarding delicate tissues during manipulation. PA 6-0 provides reliable protection, while 7-0 PVF and PGA are recommended for fragile mucosa manipulation. These findings provide a biomechanical framework for evidence-based suture selection in periodontal plastic surgery.

PMID:41953941 | DOI:10.1111/jcpe.70127