Tag: nevin manimala

Sci Rep. 2025 May 1;15(1):15265. doi: 10.1038/s41598-025-00415-6.

ABSTRACT

Fear of disease progression (FoP) is a multidimensional concept that refers to the fear or worry about disease progress. Little is known about the distinct FoP profiles and their determinants in culturally specific contexts, especially among hematologic malignancies (HM) patients in China. This study aimed to identify heterogeneous profiles of FoP and their associated predictors among Chinese patients with HM. A convenience sample of patients suffering from HM were enrolled from March 2023 to February 2024. To gather multidimensional data from the Fear of Progression Questionnaire-Short Form (FoP-Q-SF), the Brief Illness Perception Questionnaire (BIPQ), the Hospital Anxiety and Depression Scale (HADS), the Family Hardiness Index (FHI), and the EuroQol-Visual Analogue Scale (EQ-VAS), we performed a questionnaire-based cross-sectional study on 455 survivors with HM. The statistical method included latent profile analysis (LPA) and multivariate logistic regression. Three latent profiles of FoP were found: the low-risk fear group (20.88%), the moderate-risk fear group (54.73%), and the high-risk fear group (24.49%). Patients with higher levels of illness perception, anxiety, and depression were more likely to report higher levels of FoP. The study revealed that female gender (OR 2.295-2.577), age > 65 years (OR 4.140-9.363), lower education (OR 0.270-0.365), and lymphoma diagnosis (OR 2.95) significantly predicted higher FoP risk (all P < 0.05), while higher income (OR 0.390-0.477, P < 0.05) and greater family resilience showed protective effects. The findings underscore the need for risk-stratified interventions targeting psychosocial vulnerabilities, particularly in elderly and female adults with HM. This study provides empirical evidence supporting the application of precision psycho-oncology approaches in HM survivorship management. It also contributes to the broader comprehension of FoP and highlights the importance of family-centered interventions .

PMID:40312507 | DOI:10.1038/s41598-025-00415-6

Sci Rep. 2025 May 1;15(1):15311. doi: 10.1038/s41598-025-00218-9.

ABSTRACT

Previous studies have identified various factors affecting dengue fever, but most focus on correlations within specific regions, not establishing causality. This study uses Convergent Cross Mapping (CCM) to explore the causal relationships between nine meteorological factors and reported dengue fever cases in 14 Chinese provinces with the highest incidence. Results show that temperature and pressure have causal links with case numbers in more provinces. In Guangdong, which has the most reported cases, Partial Cross Mapping (PCM) reveals a direct causal relationship only between GDP and reported dengue fever cases, while meteorological factors influence dengue fever via their impact on mosquito populations. Principal Component Analysis (PCA) from 30 provinces further confirms the importance of temperature and pressure. Given the significant negative correlation between temperature and pressure, separate models were developed for each province using the Distributed Lag Nonlinear Model (DLNM) combined with the Generalized Additive Model (GAM), with GDP as a covariate. The results indicate that the Relative Risk (RR) increases significantly under high temperatures and low pressure within a shorter lag period. GDP significantly promotes case numbers in all provinces.

PMID:40312495 | DOI:10.1038/s41598-025-00218-9

Sci Rep. 2025 May 1;15(1):15296. doi: 10.1038/s41598-025-99603-7.

ABSTRACT

Cultivated meat may be an ethical, environmentally friendly, antibiotic-free meat alternative of the future. As of now, one of the main limiting factors for bringing cultivated meat to the market is the high cost of the cell culture media and their great dependency on serum albumins, production of which is predicted to become a major bottleneck of this industry. Here, using bovine muscle stem cells, we optimized serum free B8/B9 medium. We identified several food grade, low-price medium stabilizers, exhibiting comparable or even superior stabilization of the B8 medium in short- and long-term cultivations, as compared to recombinant human serum albumin. We show transferability of our approach to other satellite cells (porcine, chicken) and CHO cells, though significant cell-line specific differences in response to stabilizers were observed. Thus, we provide an alternative to serum albumin, enabling up to an overall 73% reduction of medium price for certain cell lines.

PMID:40312489 | DOI:10.1038/s41598-025-99603-7

Sci Rep. 2025 May 1;15(1):15293. doi: 10.1038/s41598-025-92247-7.

ABSTRACT

Knee osteoarthritis (OA) and atopic diseases are both characterized by chronic inflammation, yet their potential relationship remains unexplored. This study investigates whether atopic diseases are associated with an increased risk of knee OA in a large nationwide cohort. We conducted a nationwide cohort study using data from the Korean National Health Insurance Service (NHIS), including 880,300 individuals aged ≥ 50 years. Atopic disease was defined as ≥ 3 outpatient visits for asthma, allergic rhinitis, or atopic dermatitis. Knee OA incidence was identified using ICD-10 codes, and hazard ratios (HRs) were estimated using Cox proportional hazards models. Individuals with atopic diseases had a 36% higher risk of developing knee OA compared to those without (HR = 1.36, 95% CI: 1.35-1.37). A dose-response relationship was observed, with risk increasing progressively in individuals with multiple atopic conditions (HR = 1.44 for two conditions; HR = 1.51 for all three conditions). Subgroup analyses indicated that this association was strongest in younger individuals (50-59 years) and males. The results indicate a significant association between atopic diseases and an increased risk of knee OA, which was strongest in younger individuals. Further research is needed to understand the potential role of atopic-specific inflammation on OA development, and any potential implications for targeted therapies.

PMID:40312487 | DOI:10.1038/s41598-025-92247-7

Surg Endosc. 2025 May 1. doi: 10.1007/s00464-025-11734-0. Online ahead of print.

ABSTRACT

OBJECTIVE: Totally extraperitoneal (TEP) repair involves creating a preperitoneal space. The preperitoneal space can be created by telescopic dissection (TD) or plane dissection (PD). Nevertheless, these techniques may have some complications. This study aims to assess the impact and comprehensively compare the TD and PD methods in patients undergoing laparoscopic TEP inguinal hernia repair.

METHODS: A retrospective analysis was conducted on 156 patients who underwent PD at the Hospital from January 2017 to December 2023. Using propensity score matching (PSM), 312 TD patients were matched at a 1:2 ratio. The primary outcomes included peritoneal injury, vascular injury, clarity of the surgical field, operation time, and intraoperative blood loss. Secondary outcomes included length of hospital stay, postoperative pain, and recurrence rate.

RESULTS: After matching, no significant differences in clinical characteristics were observed between the two groups. The PD group showed better the surgical field clarity, reduced intraoperative blood loss, and shorter operation time compared to the TD group. Additionally, the TD group had higher hospitalization costs. There were no statistically significant differences in hospital stay and follow-up duration between the two groups. There was a significant difference in the overall complication rate between the PD and TD groups, mainly in terms of peritoneal and vascular injuries. There was no statistical difference in severe complications (Clavien-Dindo classification) between the two groups. There was also no significant difference between the two groups in terms of incision infection, seroma, hematoma, chronic pain, and recurrence rate between the groups.

CONCLUSION: Both plane dissection and telescopic dissection demonstrate efficacy and reliability in TEP surgery. The PD group showed superior performance in terms of clarity of the surgical field, reduction of peritoneal and vascular injuries, and could shorten hospital stays and reduce costs. Therefore, plane dissection has considerable potential for application in TEP surgery.

PMID:40312485 | DOI:10.1007/s00464-025-11734-0

Sci Rep. 2025 May 1;15(1):15272. doi: 10.1038/s41598-025-99179-2.

ABSTRACT

This study explores the relationship between Behçet’s disease (BD) and serum lipid levels, focusing on a large cohort to understand the correlation between lipid profile variations and BD. Utilizing data from the Korean National Healthcare Insurance Service, it encompasses 9,914,049 individuals who participated in health screenings in 2009. The research identifies patients diagnosed with BD during a follow-up period and analyzes their lipid profiles, categorized into quartiles of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). The study calculates adjusted hazard ratios (aHR) considering age, gender, smoking history, alcohol consumption, exercise habits, income, body mass index, hypertension, and diabetes, to evaluate the impact of lipid concentrations on BD development. Results show a significant increase in BD incidence among those with lower TC and HDL-C levels (aHR for lowest vs. highest TC quartile: 1.57, 95% CI 1.40-1.76, p < 0.0001; aHR for lowest vs. highest HDL-C quartile: 1.66, 95% CI 1.48-1.86, p < 0.0001), while LDL-C and TG levels did not exhibit a statistically significant association with BD risk. Additionally, the risk of BD does not escalate in the low HDL group using lipid-lowering agents (aHR: 1.33, 95% CI 0.93-1.90, p = 0.8496). The study concludes that lower TC and HDL-C levels are associated with an increased risk of developing BD.

PMID:40312472 | DOI:10.1038/s41598-025-99179-2

Diabetol Metab Syndr. 2025 May 2;17(1):148. doi: 10.1186/s13098-025-01711-x.

ABSTRACT

BACKGROUND: The α-klotho is crucial in diabetes and its related complications. This study seeks to explore the link between α-klotho levels and the risk of diabetic kidney disease (DKD) as well as all-cause and cardiovascular mortality among individuals with type 2 diabetes mellitus (T2DM).

METHODS: The investigation involved 126 Chinese T2DM patients and 4,451 individuals from the National Health and Nutrition Examination Survey (NHANES) database. To evaluate the relationship between α-klotho levels and DKD risk, multivariate logistic regression was utilized. Additionally, restricted cubic spline (RCS) regression analysis was conducted to examine the nonlinear relationship between α-klotho levels and DKD incidence. RCS analysis was employed to explore the correlation between α-klotho and both all-cause and cardiovascular mortality.

RESULTS: In the Chinese cohort, α-klotho levels were notably elevated in T2DM group compared to DKD group. The NHANES data revealed a significant inverse relationship between α-klotho levels and DKD risk. Nonlinear analysis further illustrated a substantial nonlinear connection between α-klotho levels and DKD risk. Serum α-klotho levels below 880.78 pg/mL were linked to increased DKD risk in T2DM patients. When compared to the T2DM group, the DKD group had markedly higher all-cause and cardiovascular mortality rates, with the α-klotho low group (e.g., Q1) exhibiting lower survival compared to other groups. Cox regression findings indicated that elevated α-klotho levels could mitigate all-cause mortality in T2DM patients. The relationship between α-klotho levels and all-cause mortality was also nonlinear, with the minimal risk found at α-klotho levels between 776.95 pg/mL and 812.69 pg/mL, varying by gender.

CONCLUSION: There exists a notable association between α-klotho levels and DKD risk, along with mortality in T2DM patients, with varying effects based on gender. These results highlight the potential importance of α-klotho as both a biomarker and a therapeutic target.

PMID:40312464 | DOI:10.1186/s13098-025-01711-x

Sci Rep. 2025 May 1;15(1):15288. doi: 10.1038/s41598-025-00323-9.

ABSTRACT

The primary aim of this study was to investigate the knowledge, attitude, and practice(KAP) concerning Helicobacter pylori (H. pylori) and the factors influencing them among northeast China individuals. A questionnaire regarding H. pylori, grounded in the KAP theoretical framework, was tailored for northeast China individuals. The questionnaire was conducted online and analyzed statistically. Additionally, structural equation modeling was applied to verify the interconnections among social media usage, knowledge, attitude, and practice. A total of 712 valid questionnaires were analyzed. The mean scores were 2.69 ± 1.03 for knowledge, 4.09 ± 0.81 for attitude, and 3.40 ± 0.73 for practice. Various factors including sex, occupation, and social media usage influenced knowledge, attitude, and practice scores, with social media usage exerting a notable impact on all facets. The structural equation modeling analysis demonstrated that social media usage promoted higher levels of knowledge, attitude, and practice regarding H. pylori. Individuals possessing a higher level of knowledge and attitude concerning H. pylori demonstrated superior preventive practice. Northeast China residents have limited H. pylori knowledge but show a positive attitude and good preventive practice. The utilization of social media has significantly improved the population’s knowledge, attitude, and practice concerning H. pylori.

PMID:40312460 | DOI:10.1038/s41598-025-00323-9

Sci Data. 2025 May 1;12(1):723. doi: 10.1038/s41597-025-04996-9.

ABSTRACT

Most multi-region input-output (MRIO) tables in China focus on provinces or urban agglomerations and ignore the tremendous geographical heterogeneities of economic activities across Chinese prefectural cities, where regional economic centres are usually located for domestic and global production. This paper constructs an inter-city input-output (IO) database with 42 sectors in the Greater China area. Compared with previous MRIO tables, it has three important features: (1) A complete coverage of Chinese cities, including 335 prefectural cities, four municipalities, and Hong Kong, Macao, and Taiwan; (2) Distinguishes three types of firm ownership for every city and sector for four benchmark years; (3) A novel data completion approach to reconcile all accessible micro-level data with city and provincial-level aggregate statistics, and effectively combining the bottom-up and top-down methods commonly used in the MRIO compilation literature. The database can be used in a diverse range of socioeconomic and interdisciplinary issues in the Greater China area at the city level. It also sheds light on other large economies to develop their own inter-city IO tables.

PMID:40312452 | DOI:10.1038/s41597-025-04996-9

Animal. 2025 Apr 3;19(5):101506. doi: 10.1016/j.animal.2025.101506. Online ahead of print.

ABSTRACT

Many farmers rely on anthelmintics to control gastrointestinal nematodes in sheep. In response to concerns about rising levels of anthelmintic resistance reported in countries around the world, current advice is to adopt more sustainable practices. A small-scale survey of farmers was used to inform group discussions with farmers, veterinarians and anthelmintic prescribers, to better understand barriers to the adoption of sustainable gastro-intestinal nematode control in sheep flocks across the United Kingdom. Thematic analysis of the discussions identified four barriers to change: not seeing the need for change; lack of specific information and support in implementing changes on farm; lack of confidence in the new approaches; and practical obstacles such as time and cost. Nevertheless, there were examples of sustainable parasite control with some farmers making changes to their habitual practices, typically with the support of their veterinarian or Suitably qualified person. We reflect on the findings through the lens of the Capability, Opportunity, Motivation as drivers of Behaviour model. This draws attention to the need for a process of knowledge exchange that allows advice to be tailored to individual farms and makes use of farmer skills and experiences, rather than expecting farmers to follow generic advice.

PMID:40311159 | DOI:10.1016/j.animal.2025.101506