Tag: nevin manimala

Sleep Med. 2021 Jul 30;85:313-316. doi: 10.1016/j.sleep.2021.07.036. Online ahead of print.

ABSTRACT

BACKGROUND: There is a critical gap in identifying effective interventions for children with obstructive sleep apnea (OSA) who do not tolerate continuous positive airway pressure therapy. Positional OSA (POSA) is a common clinical phenotype whereby OSA occurs predominantly while sleeping in supine position. POSA may be amenable to treatment with a positional device, a belt worn around the chest with cushions on the back to prevent supine positioning, but no data exists in children. The primary aim of this study was to evaluate the efficacy of positional device therapy for the treatment of POSA in children.

METHODS: This observational study included children aged 4-18 years with POSA and an obstructive apnea-hypopnea index (OAHI) ≥ 5 events/hour on baseline polysomnogram (PSG) who underwent a second PSG to evaluate the efficacy of a positional device. The primary outcome was the change in OAHI.

RESULTS: Ten children were included (8 male, median age 11.2 years, median body mass index z-score 1.6). Compared to the baseline PSG, PSG data obtained while using a positional device showed a reduced median (interquartile range) OAHI (15.2 [8.3-25.6] versus 6.7 [1.0-13.7] events/hour respectively; p = 0.004) and percentage of total sleep time in supine position (54.4 [35.0-80.6]% versus 4.2 [1.1-25.2]% respectively; p = 0.04). Despite observed improvements in the oxygen desaturation index, these results were not statistically significant.

SIGNIFICANCE AND CONCLUSIONS: In this novel pilot study, positional device therapy was effective for the treatment of POSA. Positional device therapy may potentially change clinical practice as a cost-efficient and non-invasive treatment option for POSA.

PMID:34399395 | DOI:10.1016/j.sleep.2021.07.036

J Surg Res. 2021 Aug 13;268:337-346. doi: 10.1016/j.jss.2021.06.075. Online ahead of print.

ABSTRACT

BACKGROUND: Ventral hernia repair (VHR) has been shown to improve overall quality of life (QOL) by the validated 12-question Hernia-Related Quality-of-Life survey (HerQLes). However, which specific aspects of quality of life are most affected by VHR have not been formally investigated.

METHODS: Through retrospective analysis of the Abdominal Core Health Quality Collaborative national database, we measured the change in each individual component of the HerQLes questionnaire from a pre-operative baseline assessment to one-year postoperatively in VHR patients.

RESULTS: In total, 1,875 VHR patients had completed both pre- and post-operative questionnaires from 2014-2018. They were predominately Caucasian (92.3%), 57.9 ± 12.4 Y old, and evenly gender split (50.5% male, 49.5% female, P = 0.31). Most operations were performed open (80.5%) with fewer laparoscopic (7.5%) or robotic cases (12.1%). For each of the 12 individual categories, improvement in QOL from baseline to 1-Y was found to be statistically significant (P < 0.0001). This held true with subgroup analysis of small (<2 cm), medium (2-6 cm), and large (>6 cm) hernias (P < 0.0001), though a larger improvement was seen in 8 of 12 components in hernias >6 cm (P < 0.001). Operative approach did not carry a significant effect except in medium hernias (2-6 cm), where an open approach saw a greater improvement in the “accomplish less at work” item (P = 0.02).

CONCLUSIONS: VHR is associated with improvement in each of the 12 components of QOL measured in the HerQLes questionnaire, regardless of the size of their hernia. The amount of improvement, however, may be dependent on hernia size and approach.

PMID:34399356 | DOI:10.1016/j.jss.2021.06.075

J Surg Res. 2021 Aug 13;268:363-370. doi: 10.1016/j.jss.2021.06.073. Online ahead of print.

ABSTRACT

OBJECTIVE: Laparoscopic appendectomy is a common operation that is frequently performed by junior surgical residents. We investigated the effect of a structured training program on the proficiency of junior residents in acquiring skills necessary in this operation.

DESIGN AND PARTICIPANTS: This is a randomized pilot trial. Between December 2014 and July 2018, twenty junior residents were recruited for this study. 11 were randomized to receive a structured training program of supervised, task-specific training. Each resident subsequently performed ten cases of laparoscopic appendectomy with their performance assessed for the last 5. The GOALS scale was used as the primary endpoint. Secondary endpoints were perioperative outcomes. The effect of intervention on these outcomes were evaluated assuming a linear mixed effect multi-level model. The study was single-blinded as the assessors did not know which group each resident belonged to.

RESULTS: There were no statistically significant differences in the total GOALS score or any of its individual domains. After adjusting for the number of operations done within the trial, the mean difference between the total GOALS score was 0.07 (95% CI -0.76 to 0.90, P=0.866). Blood loss, hospital stay and postoperative complication rates were similar. There was suggestion of a shorter operative time (effect estimate -9.03, 95% CI -19.56 to 1.50) in the intervention arm although statistical significance was not achieved. No avoidable adverse events due to this study were recorded.

CONCLUSION: Structured training program did not significantly improve surgical performance and outcomes in laparoscopic appendectomy in this pilot trial. Despite these findings, residents can still potentially mount their learning curves in laparoscopy earlier in a safe environment with such a program which is especially important in the era of minimally invasive surgery.

PMID:34399358 | DOI:10.1016/j.jss.2021.06.073

Sci Total Environ. 2021 Aug 8;800:149404. doi: 10.1016/j.scitotenv.2021.149404. Online ahead of print.

ABSTRACT

The altitudinal distribution of biodiversity in alpine ecosystems has captured academic attention, especially in streams because of their sensitivity to climate change. In the past years, research mainly focused on understanding the role played by alpine streams’ internal factors such as aquatic environmental variables, as well as physical and hydrological conditions, on the shaping of benthic macroinvertebrate communities. More recently, external factors such as terrestrial environments were included in analyses worldwide. In particular, the inherent properties constituting the ecological niche of specific species were considered as factors regulating dispersal and influencing community construction. The objective of this study was to reveal the distribution pattern and the driving factors regulating aquatic biodiversity in alpine streams. We hypothesized that the altitudinal distribution of aquatic macroinvertebrates could be explained by the interaction of the aquatic environment with both species’ ecological niche and the terrestrial environment surrounding their habitat, and that rare species display a more pronounced pattern than widespread dominant species. To test these hypotheses, samples were collected from two alpine streams situated on opposite slopes of Biluo Snow Mountain in Yunnan Province, China. Results of statistical analyses showed poor explanatory power from aquatic environmental factors, while the differences in vegetation type and the ecological niche of the species played an important role in determining the distribution pattern of aquatic biodiversity. Furthermore, we found that the altitudinal distribution pattern of aquatic biodiversity exhibits a bimodal type, with rare species fitting the bimodal peaks. These findings call for a better inclusion and further investigation on the effects of the terrestrial environment on aquatic ecosystems.

PMID:34399334 | DOI:10.1016/j.scitotenv.2021.149404

Sci Total Environ. 2021 Aug 3;800:149340. doi: 10.1016/j.scitotenv.2021.149340. Online ahead of print.

ABSTRACT

Pharmaceutically active compounds (PhACs) present in the environment are a great threat to human well-being and the ecosystem. Eventhough recognized as the pharmacy of the world”, studies addressing the distribution of PhACs in the Indian environment are scarce. Hence, in the current study, selected PhACs, heavy metals (HMs), and physicochemical parameters (PCPs) were measured from the surface waters of the River Cauvery during the pre- and post-monsoon. PhACs such as caffeine, carbamazepine, and diclofenac were detected in most samples, whereas topiramate, ibuprofen, and verapamil were found only in few stations. In contrast, the distribution of ciprofloxacin, atenolol, and isoprenaline was strongly influenced by the seasonal pattern (p < 0.05). PhACs such as loperamide, glafenine, erythromycin, and gemfibrozil were not detected during the study. Distribution of PhACs based on average concentration (ng/L) are, CBZ (205.62) > CAF (114.09) > DCF (28.51) > CIP (25.23) > ATL (18.86) > IPL (13.91) > PPL (11.26) > TCS (10.39) > IBF (7.34) > TPT (3.09) > VPL (1.16). Bivariate and multivariate statistical analyses have revealed a positive correlation expressed by the majority of the PhACs with PCPs (COD, TOC), nutrients (TN, TP), and HMs (Pb, Mn, Ni) in the range from 0.540** to 0.961**(p < 0.01). Whereas, DO revealed negative correlation with most of the parameters in the range from -0.559** to -0.831** (p < 0.01). A high average concentration of PhACs was recorded in the upstream (52.08 ng/L) and wastewater discharge points (55.60 ng/L). Further, the environmental risk assessment study has identified the higher risk exhibited by TCS (RQ: 3.29) and CAF (RQ: 38.82) on algae and Daphnia respectively. The study portrays the distribution of emerging contaminants in the River Cauvery and its tributaries and also delivers preliminary data about the distribution of isoprenaline, topiramate, verapamil, and perindopril in the Indian freshwater system.

PMID:34399341 | DOI:10.1016/j.scitotenv.2021.149340

Int J Food Microbiol. 2021 Jul 28;356:109333. doi: 10.1016/j.ijfoodmicro.2021.109333. Online ahead of print.

ABSTRACT

Toxoplasmosis is a globally spread disease, affecting humans and many animal species, including birds. Antibodies to Toxoplasma gondii were detected in ostriches from South and North America, Africa and Asia. Except for one study from Spain, there is a lack of information about T. gondii seroprevalence in ostriches from Europe. For this reason, the aim of the study was to detect antibodies to T. gondii in farm-reared ostriches from the Czech Republic. Serum samples of 409 ostriches (Struthio camelus), collected at 9 farms were tested by Latex agglutination test. Antibodies to T. gondii were detected in 149 (36%) birds with a statistical difference for individual farms (8%-71%, p = 0.0121), and regions (8%-65%, p = 0.002). Seropositivity did not statistically differ (p > 0.05) in size of farms (50% and 35% on small and large farms, respectively), sex of birds (38% and 35% in males and females, respectively), season and year of collection. Tissue samples (brain, heart, and pectoral muscle) of 105 birds were also tested by PCR to detect T. gondii DNA. The parasite T. gondii was detected in the brain and heart of one seronegative ostrich (1%) from a small farm. Based on our results, we can assume that ostriches may present high risk of toxoplasmosis for humans through consumption of raw or undercooked ostrich meat and even seronegative individuals could harbor T. gondii in their tissues. To our knowledge, this is the first serological detection of T. gondii in ostriches in the Czech Republic, and the first PCR detection in Europe.

PMID:34399305 | DOI:10.1016/j.ijfoodmicro.2021.109333

Arch Gerontol Geriatr. 2021 Aug 9;97:104501. doi: 10.1016/j.archger.2021.104501. Online ahead of print.

ABSTRACT

The directionality of the longitudinal association between depressive symptoms and memory remains a topic of intense debate. A unidirectional association where depression impacts the change in memory (or vice-versa) and a bidirectional association where the trajectories of both dimensions affect each other lead to different clinical implications.

METHOD: This study investigated the depression-memory longitudinal association in a sample of 2057 older adults aged between 60 and 99 years old from the Virginia Cognitive Aging Project. The bivariate dual change score model was used to investigate the directionality of the association between episodic memory and three dimensions of depression (somatic symptoms, depressed affect, and positive affect) throughout ten years (five measurement points), controlling for education and sex.

RESULTS: the bidirectional model showed the best fit between somatic symptoms and memory, with a significant coupling effect observed from initial somatic symptoms to subsequent changes in memory. For depressed and positive affect, the unidirectional model with initial levels of depression predicting following changes in memory showed the best fit to the data, with significant coupling effects observed. Higher initial levels of somatic symptoms and depressed affect predicted a subsequent decline in memory, and higher initial levels of positive affect predicted subsequent better memory performance. Statistical adjustments for covariates (education and sex) had no significant influence on these associations.

CONCLUSIONS: Our findings support a unidirectional association with higher depressive symptoms preceding a steeper decline in memory in older adults. We discuss the clinical implications for depressive symptoms as a predictor of subsequent memory decline.

PMID:34399242 | DOI:10.1016/j.archger.2021.104501

Soc Sci Med. 2021 Aug 12;285:114313. doi: 10.1016/j.socscimed.2021.114313. Online ahead of print.

ABSTRACT

There has been limited theoretical and empirical research into the role of workplace accommodations in enabling workers with and without impairments to remain in work. This study used the International Classification of Functioning, Disability and Health (ICF) model to examine (a) whether workplace accommodations enable workers, particularly those with different impairments, to remain economically active; and (b) the predictors of the onset of work accommodations. Data from two waves of a large-scale longitudinal survey of disability in Great Britain, the Life Opportunities Survey (2009-2012) were analysed. 2307 workers with an impairment and 4308 workers without an impairment were followed up for a year. Work accommodations appear to enable workers with impairments to remain economically active, especially those with mental impairments. There was no difference in the employment rates of workers with and without mental impairments who had two or more work accommodations, in contrast to the 10% employment gap between workers with and without mental impairments who did not have any work accommodations. While there was no gender difference in the disability employment gap, barriers to employment related to caregiving were much greater for women compared to men. Moreover, only workers with incident pain impairments were associated with an increase in their work accommodations, not workers with incident mental impairments. Despite the evidence that workers with mental impairments could benefit considerably from workplace accommodations, they are less likely to have their workplace adjusted. The ICF model is particularly useful in analysing the role of work accommodations because it considers a much wider range of factors that are relevant not just to workers with different types of impairments, but are also relevant to the wider group of workers who use workplace accommodations.

PMID:34399292 | DOI:10.1016/j.socscimed.2021.114313

J Hazard Mater. 2021 Jul 27;422:126724. doi: 10.1016/j.jhazmat.2021.126724. Online ahead of print.

ABSTRACT

Improper healthcare waste (HCW) management poses significant risks to the environment, human health, and socio-economic sustainability due to the infectious and hazardous nature of HCW. This research aims at rendering a comprehensive landscape of the body of research on HCW management by (i) mapping the scientific development of HCW research, (ii) identifying the prominent HCW research themes and trends, and (iii) providing a research agenda for HCW management towards a circular economy (CE) transition and sustainable environment. The analysis revealed four dominant HCW research themes: (1) HCW minimization, sustainable management, and policy-making; (2) HCW incineration and its associated environmental impacts; (3) hazardous HCW management practices; and (4) HCW handling and occupational safety and training. The results showed that the healthcare industry, despite its potential to contribute to the CE transition, has been overlooked in the CE discourse due to the single-use mindset of the healthcare industry in the wake of the infectious, toxic, and hazardous nature of HCW streams. The findings shed light on the HCW management domain by uncovering the current status of HCW research, highlighting the existing gaps and challenges, and providing potential avenues for further research towards a CE transition in the healthcare industry and HCW management.

PMID:34399217 | DOI:10.1016/j.jhazmat.2021.126724

J Hazard Mater. 2021 Aug 8;422:126857. doi: 10.1016/j.jhazmat.2021.126857. Online ahead of print.

ABSTRACT

Nowadays, the global spreading of hazardous heavy metals becomes a top-priority environmental challenge, owing to its serious detrimental health outcomes. Herein, a novel cysteine-doped polyaniline@faujasite hybrid composite (Cys-PANi@FAU-50) was synthesized via a facile in-situ polymerization route for the effective detoxification of Cr(VI)-bearing wastewaters. The Cys-PANi@FAU-50 composite displayed an open mesoporous structure richly decorated with nitrogen/oxygen-containing functional groups, which consequently boosted the diffusion, adsorption and reduction of Cr(VI) oxyanions. The Cr(VI) adsorption behavior was satisfactorily tailored via pseudo-second-order law and Langmuir model with a maximum uptake capacity of 384.6 mg/g. Based on the advanced statistical physics theory, the monolayer model with two distinct receptor sites provided a reliable microscopic and macroscopic prediction of the Cr(VI) adsorption process. Stereographically, the Cr(VI) ions were adsorbed through horizontal multi-anchorage and vertical multi-molecular mechanisms on the amine and hydroxyl groups of Cys-PANi@FAU-50, respectively. The thermodynamic functions evidenced that the Cr(VI) adsorption was an endothermic spontaneous process. XPS analysis proved that Cr(VI) ions were electrostatically adsorbed, and subsequently reduced to Cr(III), which were in turn immobilized by chelation with imine/sulfonate groups and electrostatic interactions with carboxylate groups. The Cys-PANi@FAU-50 featured an effortless regenerability and good reusability. Overall, the Cys-PANi@FAU-50 composite owns outstanding potentiality for detoxifying Cr(VI)-laden effluents.

PMID:34399223 | DOI:10.1016/j.jhazmat.2021.126857