Tag: nevin manimala

Epilepsia. 2025 Aug 19. doi: 10.1111/epi.18604. Online ahead of print.

ABSTRACT

OBJECTIVE: To assess and compare the detection rates of peri-ictal abnormalities using magnetic resonance imaging (MRI) and computed tomography perfusion (CTP) in patients with non-convulsive status epilepticus (NCSE).

METHODS: We conducted a systematic literature search in five databases up to February 2025. Studies reporting peri-ictal MRI abnormalities (PMAs) or cerebral perfusion abnormalities (CPAs) in patients with NCSE were included. Meta-analyses of proportions were performed using a random-effects model. Subgroup analyses and meta-regression were used to compare detection rates across imaging modalities.

RESULTS: Nineteen studies were included (15 MRI, 4 CTP), comprising 562 patients for MRI and 72 for CTP. The pooled detection rate of peri-ictal abnormalities was 50.0% (95% confidence interval [CI]: 34.0%-65.0%) for MRI and 79.3% (95% CI: 54.3%-92.5%) for CTP. Among the MRI modalities, arterial spin labeling (ASL) demonstrated the highest detection rate at 88.8% (95% CI: 32.9%-99.2%). CTP showed a significantly higher detection rate than MRI (χ² = 3.97, p = 0.046); meta-regression indicated increased odds of detection with CTP (odds ratio [OR] = 4.06, 95% CI: 0.97-16.99, p = 0.055). No statistically significant difference was found between ASL and CTP (χ² = 0.22, p = 0.636).

CONCLUSIONS: CTP demonstrates a higher detection rate than conventional MRI for peri-ictal abnormalities in patients with NCSE, supporting its utility in rapid diagnosis and differential workup. Among MRI sequences, ASL showed the highest detection rates, highlighting its potential role in the diagnostic assessment of NCSE. Although MRI remains essential for clarifying etiology, its effectiveness in detecting PMA is highly dependent on the sequences used.

PMID:40827398 | DOI:10.1111/epi.18604

Hypertension. 2025 Aug 19. doi: 10.1161/HYPERTENSIONAHA.125.25003. Online ahead of print.

ABSTRACT

BACKGROUND: Preeclampsia is characterized by hypertension, proteinuria, and elevated antiangiogenic sFlt-1 (soluble fms-like tyrosine kinase-1) levels. Despite extensive research, mechanisms underlying sFlt-1 dysregulation remain unclear. This hypothesis-testing study investigated whether ferroptosis, a lipid peroxidation-driven cell death mechanism, contributes to preeclamptic placental pathogenesis and sFlt-1 release, and whether drug repurposing could identify novel therapeutic options.

METHODS: We analyzed oxidized phosphatidylethanolamines in human preeclamptic and healthy placental tissues using redox phospholipidomics. In placental explants, we evaluated ferroptosis effects on sFlt-1 release using Ferrostatin-1 and deferoxamine as inhibitors. We screened 6520 FDA-approved drugs (pregnancy categories A-C) to identify effective ferroptosis inhibitors in primary trophoblasts. Statistical analyses used Student t test and 1-way ANOVA with multiple comparison corrections.

RESULTS: Preeclamptic placentas showed significant accumulation of oxidized phosphatidylethanolamines compared with controls. Inducing ferroptosis in placental explants increased sFlt-1 release, while inhibition using Ferrostatin-1 and deferoxamine reduced sFlt-1 levels (P<0.01). Our screen identified dipyridamole and promethazine as potent ferroptosis inhibitors, reducing lipid peroxidation, preserving glutathione levels, and decreasing sFlt-1 release in preeclamptic explants.

CONCLUSIONS: This study establishes placental ferroptosis as a key mechanism in early preeclampsia and demonstrates its direct link to sFlt-1 dysregulation. Our systematic drug screening approach identified approved drugs with antiferroptotic activity, suggesting a novel therapeutic strategy for preeclampsia management through drug repurposing. Further research is needed to establish optimal dosing and confirm efficacy in vivo.

PMID:40827397 | DOI:10.1161/HYPERTENSIONAHA.125.25003

Clin Neuropsychol. 2025 Aug 19:1-20. doi: 10.1080/13854046.2025.2541661. Online ahead of print.

ABSTRACT

Objective: Intra-individual cognitive variability (IICV) has been found to predict cognitive decline and dementia incidence among older adults based on a one follow-up testing paradigm while the association between IICV and daily functioning is less studied. The current study intended to investigate the predictability of IICV on the trajectory of decline in cognition and self-report daily functioning among older adults, tracked with multiple time points. Method: The current study employed a diverse, longitudinal, archival data set from the Rush Alzheimer’s Disease Center (N = 4,319) and examined 5 waves of data with growth curve modeling. Multiple sensitivity analyses were followed up to scrutinize the robustness of study results, accounting for demographic covariates, baseline mean cognitive performance, skewness, and attrition. Results: Results supported the main hypothesis that the trend of IICV predicted the trajectory of cognition, β = .-57, p = .002, and self-reported daily functioning, β = .48, p = .037, and the results were robust against the inclusion of covariates, skewness, and attrition. Conclusions: With a rigorous methodology and statistical approach, the current study contributed to the scientific and medical understanding of IICV and lent support to the clinical use of IICV in neuropsychological assessment. Methodological strengths and limitations were noted.

PMID:40827377 | DOI:10.1080/13854046.2025.2541661

Urol Res Pract. 2025 Jul 29;51(4):136-140. doi: 10.5152/tud.2025.24053.

ABSTRACT

Objective: This retrospective cross-sectional study aimed to compare functional and surgical outcomes after open simple prostatectomy (OSP) between patients who underwent prior transurethral resection of the prostate (TURP) and those who did not. Methods: Between March 2009 and April 2019, 723 patients underwent TURP, of whom 20 (2.7%) subsequently underwent OSP (Group 1). This group was matched with a group of patients who had solely undergone OSP (Group 2), with matching criteria including age, prostate-specific antigen level, prostate volume, and prostate weight. Results: Group 1 showed a statistically significant lower decrease in hemoglobin levels after surgery (p = .006); however, no significant differences were observed between the groups in terms of operation time (P=.508), hospital stay (P=.065), transfusion rate (P=.331), enucleated prostate volume (P=.733), or changes in creatinine levels (P =.418). Regarding early postoperative complications, the 2 groups showed no significant difference (0.349). Late postoperative complications occurred in 30% of Group 1 and 33% of Group 2, which was not significantly different either (P = .241). Both groups achieved similar early continence rates (88%) within the first 6 months after surgery. Late continence rates (after 6 months) were also comparable, with 94% in Group 1 and 88% in Group 2. Finally, no significant differences were found in patient satisfaction levels, measured on a qualitative scale ranging from “dissatisfied” to “highly satisfied.” Conclusion: Prior TURP did not significantly affect the surgical or functional outcomes of subsequent OSP, with comparable results observed between patients with and with- out a history of TURP.

PMID:40827367 | DOI:10.5152/tud.2025.24053

Psychiatry Clin Psychopharmacol. 2025 Jun 25;35(3):304-310. doi: 10.5152/pcp.2025.241063.

ABSTRACT

Background: Rhinoplasty, performed for aesthetic and functional purposes, is among the most common cosmetic procedures worldwide. While previous studies have investigated the impact of social media and self-esteem on cosmetic surgery motivations, comparisons between aesthetic and functional rhinoplasty candidates remain limited. This study evaluates the sociodemographic, psychological, and behavioral profiles of these groups, focusing on social media use and self-esteem. Methods: This cross-sectional study included 103 rhinoplasty candidates divided into 2 groups based on their primary motivation: functional (Group 1) or aesthetic (Group 2). Data were collected using a Sociodemographic Data Form, the Rosenberg Self-Esteem Scale (RSES), and the Bergen Social Media Addiction Scale (BSMAS). Statistical analyses included chi-square, Fisher’s exact test, and Mann-Whitney U-tests. Results: Most participants (70.9%) sought rhinoplasty for aesthetic reasons. The median age of Group 2 (23.0) was significantly lower than that of Group 1 (29.5) (P < .001). Females and single individuals were more likely to seek aesthetic rhinoplasty (P < .001). Social media use, particularly Instagram, was significantly higher in Group 2; 53.4% spent over 3 hours daily on social media, compared to 10% in Group 1 (P < .001). Group 1 showed higher self-esteem scores than Group 2 (34.0 vs. 31.0, P < .001). Conclusion: Aesthetic rhinoplasty is associated with a younger age, female gender, lower self-esteem, and greater social media use. These findings emphasize the need for preoperative assessments addressing psychological vulnerabilities and social media influences to improve patient satisfaction and outcomes.

PMID:40827351 | DOI:10.5152/pcp.2025.241063

Int J Cosmet Sci. 2025 Aug 19. doi: 10.1111/ics.70020. Online ahead of print.

ABSTRACT

OBJECTIVE: Over the last two decades, consumers have been calling for greater transparency for ingredient sourcing and manufacturing practices; therefore, more sustainable alternatives need to be evaluated to meet industry demands. While many organizations give standards for ‘clean’, ‘organic’ and ‘natural’ cosmetic products, sustainable formulations lack standardization and harmonization globally. This study aimed to formulate sustainable lipsticks and moisturizers using resources and standards currently available in the cosmetic industry and compare select sustainable alternatives to a conventional control product.

METHODS: After thoroughly screening ingredients for each product type, five different lipsticks and five batches of moisturizers were formulated and tested for quality, performance and stability characteristics.

RESULTS: Pay-off and friction were the most different among the lipsticks, with M4, the lipstick containing sustainable ingredients, having the highest average friction and pay-off at Week 1. As for the moisturizers, spreadability had the largest differences, mostly due to the different emulsifier systems, as expected.

CONCLUSION: Incorporating sustainable ingredients can be challenging, but having quality products while being more environmentally friendly is possible. These case studies are meant to serve as examples for formulation chemists.

PMID:40827337 | DOI:10.1111/ics.70020

Br J Psychiatry. 2025 Aug 19:1-2. doi: 10.1192/bjp.2024.290. Online ahead of print.

NO ABSTRACT

PMID:40827330 | DOI:10.1192/bjp.2024.290

Sci Prog. 2025 Jul-Sep;108(3):368504251370988. doi: 10.1177/00368504251370988. Epub 2025 Aug 19.

ABSTRACT

ObjectiveDNA methylation is a key regulator of gene expression and plays a crucial role in cancer development. However, the mechanisms driving gene-specific methylation remain unclear. This study investigates the role of microRNAs (miRNAs) in regulating promoter methylation of specific genes, aiming to uncover miRNA-driven modulation of gene methylation in cancer.MethodsWe analyzed data from the Cancer Cell Line Encyclopedia (CCLE) database, comprising 813 cell lines. Spearman’s rank correlation was performed between the expression levels of 734 miRNAs and the methylation levels of 20,587 genes, focusing on CpG islands in promoter regions. Linear regression analysis was used to validate the relationship between selected miRNAs and gene clusters. Bioinformatics screening identified statistically significant miRNA-gene pairs involved in promoter methylation.ResultsThe analysis revealed 25 target genes whose promoter methylation was significantly associated with the expression of four miRNAs (hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, and hsa-miR-141). These correlations were most pronounced in colorectal, gastric, lung, and ovarian cancers. Notably, cancer-related genes such as ST14, OVOL1, and EPCAM were identified as targets, supporting the hypothesis that miRNAs regulate promoter methylation in these genes.ConclusionOur findings suggest that specific miRNAs induce promoter methylation in cancer-related genes, thereby influencing gene expression. This study expands our understanding of the role of miRNAs in tumor development and highlights the potential of miRNA-based therapies in cancer treatment. As this is a computational study, further experimental validation is required to confirm the proposed regulatory mechanisms.

PMID:40827314 | DOI:10.1177/00368504251370988

Acta Odontol Scand. 2025 Aug 19;84:446-456. doi: 10.2340/aos.v84.44231.

ABSTRACT

OBJECTIVE: To investigate young individuals’ esthetic perception of color on the buccal surface of maxillary anterior teeth, self-perception of own tooth color, and general dental esthetic estimates by using a web-based survey.

METHODS: A digital questionnaire was advertised on social media in 2024, targeting 18-30-year-olds in Sweden. The questionnaire included attitudes toward own tooth color, cases with molar incisor hypomineralization (MIH), fluorosis (F), white spot lesions (WSL), and general dental esthetic estimates. Chi2 assessed differences between groups, and the independent sample T-test calculated mean differences in responses. Statistical significance was set at p < 0.05.

RESULTS: Out of 2,082 respondents (55% women, 43% men, mean age 25.1 years), 77% rated their tooth color as acceptable, with no gender or age differences (p > 0.05). Pigmented fluorosis was rated as nonacceptable by 94% of the respondents, followed by cases with WSLs. At least 90% cited deviant color on a part of a tooth (DCP) as a reason for nonacceptance. Even tooth color (mean, standard deviation [SD]: 8.02, 2.36) was rated more important than white teeth (mean, SD: 7.25, 2.04), p < 0.001.

CONCLUSION: De- and hypomineralization on maxillary anterior teeth are perceived negatively by young individuals in terms of dental esthetics. An even tooth color was valued higher than white teeth.

PMID:40827308 | DOI:10.2340/aos.v84.44231

Archaeol Anthropol Sci. 2025;17(9):184. doi: 10.1007/s12520-025-02296-2. Epub 2025 Aug 16.

ABSTRACT

The El Jobo projectile points represent a distinctive design innovation of Late Pleistocene Neotropical human groups. This technology, characterized by its fusiform/lanceolate shape, has been recorded mainly in northwestern Venezuela in a variety of geographical areas and in association with megafauna killing/butchering sites. To characterize it, address its significance, and analyse possible continental relationships, four consecutive approaches were conducted. A representative sample of El Jobo projectile points was subject to technological approximation, morphological classification, outline-based geometric morphometric analysis, and elemental composition analysis. Six morphological types were recognized, for which a common series of manufacture steps was hypothesized. Mainly collateral and irregular flaking patterns were identified, also recording new basal variability, including fluting, fluting-like and reconfiguration techniques. The four most representative morphological types were subjected to morphometric analysis. Elliptic Fourier and Principal Component analyses identified at least three clusters, with width variation mainly distinguishing their shapes, and statistical tests determined significative differences between the main morphological types. The elemental analysis revealed the main use of quarzitic rocks, with variations in elemental composition indicative of diverse sources. The observed variability and cumulative evidence of El Jobo projectile points suggests their adaptation to diverse hunting strategies. The wide geographic distribution of tools and the morphometric comparison with a Monte Verde projectile suggest potential long-distance connections of El Jobo with other projectile point technologies across the continent.

SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12520-025-02296-2.

PMID:40827306 | PMC:PMC12357808 | DOI:10.1007/s12520-025-02296-2